Human Thyroid Hormone Receptor Beta (TRβ; NR1A2)
Family of Reporter Assay Systems

INDIGO's TRβ Reporter Assay System utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of Human Thyroid Hormone Receptor Beta (NR1A2), a ligand-dependent transcription factor. Because these cells incorporate a responsive luciferase reporter gene, quantifying expressed luciferase activity provides a sensitive surrogate measure of TRβ activity in the treated cells. The primary application of this reporter assay system is in the screening of test samples to quantify any functional activity, either agonist or antagonist, that they may exert against human TRβ.