Human Thyroid Hormone Receptor Alpha
(TRα; NR1A1)
Family of Reporter Assay Systems

The Human TRa Reporter Assay Systems utilize non-human mammalian cells engineered to provide constitutive, high-level expression of Human Thyroid Hormone Receptor Alpha (NR1A1), a ligand-dependent transcription factor commonly referred to as TRa. Additionally, these cells contain a TRa-responsive luciferase reporter gene. Thus, quantifying luciferase activity provides a surrogate measure of TRa activity in the treated reporter cells.