Indigo Biosciences, Inc. | Metabolic Disease: Cholesterol and Lipid Homeostasis

Metabolic Disease: Cholesterol and Lipid Homeostasis

The nuclear receptors included this assay panel influence cholesterol and lipid biosynthesis and metabolism. They are involved in obesity, diabetes, metabolic syndrome, and other disorders. Each receptor is linked to the NCBI database, Genecards, and Geneatlas. Some receptors are linked to additional pathway maps. Click on any object in a pathway for more detailed information.

Receptors		NCBI	Genecards	Geneatlas	Map
PPARalpha	Peroxisome proliferator-activated receptor-alpha	N	G	GA	M
PPARbeta	Peroxisome proliferator-activated receptor-beta	N	G	GA	M
PPARgamma	Peroxisome proliferator-activated receptor-gamma	N	G	GA	M
RXRalpha	Retinoid X receptor-alpha	N	G	GA	M
LXRalpha	Liver X receptor-alpha	N	G	GA	M
LXRbeta	Liver X receptor-beta	N	G	GA	M
FXR	Farnesoid X receptor	N	G	GA	M
VDR	Vitamin D receptor	N	G	GA	M
TRalpha	Thyroid hormone receptor-alpha	N	G	GA	M

References:

Shulman, A.I. and Mangelsdorf, D.J. "Retinoid X Receptor Heterodimers in the Metabolic Syndrome." N. Engl. J. Med.2005, 353, 604-615, 643. Abstract.

Beaven, S.W. and Tontonoz, P. "Nuclear Receptors in Lipid Metabolism: Targeting the Heart of Dyslipidemia." Annu. Rev. Med., 2006, 57, 313-29.

Some useful nuclear receptor links:

The Nuclear Receptor Resource
PPAR Resource Page
Nuclear Receptor Signaling Atlas