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Fluorescence Polarization Assays

Fluorescence Polarization (FP) is a powerful tool for measuring direct binding of small molecules to proteins of interest. This homogeneous assay avoids the need for radiolabeled probes and is amenable to high throughput screening.

We offer FP screening services for the following receptors:

  • ERα
  • ERβ
  • AR
  • PR
  • PPARγ
  • GR

    • References:

  • DeGrazia, M. J., Thompson J., Vanden Heuvel, J. P., and Peterson, B. R. "Synthesis of a High-Affinity Fluorescent PPARgamma Ligand for High-Throughput Fluorescence Polarization Assays" Bioorg. Med. Chem., 2003, 11, 4325-4332.