| Name | MAPK14 |
|---|---|
| Description | mitogen-activated protein kinase 14 |
| Owner | Public |
| URN | urn:agi-llid:1432 |
| Connectivity | 322 |
| Notes | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Hugo ID | 6876 |
| Microarray ID | 1367697_at |
|---|---|
| rc_aa924542_s_at | |
| rc_ai137862_s_at | |
| rc_ai171630_s_at | |
| u73142_at | |
| u73142_g_at | |
| u91847_s_at | |
| A_43_P12479 | |
| 1416703_at | |
| 1416704_at | |
| 1451927_a_at | |
| 99978_s_at | |
| u10871_s_at | |
| A_51_P325343 | |
| A_65_P19663 | |
| L35263 | |
| 37733_at | |
| 78240_at | |
| 211561_x_at | |
| 202530_at | |
| 211087_x_at | |
| 210449_x_at | |
| 1671_s_at | |
| 1999_s_at | |
| L35253_s_at | |
| L35263_at | |
| A_23_P214696 | |
| A_23_P426292 | |
| A_14_P139376 | |
| A_14_P138042 | |
| A_14_P129108 | |
| A_14_P111428 | |
| A_24_P283288 | |
| A_24_P397566 | |
| 704 | |
| OH7873 | |
| M190 | |
| R519 | |
| OR0693 | |
| NM_031020 | |
| 1426104_at | |
| Msa.8386.0_s_at | |
| Msa.343.0_at | |
| Msa.8386.0_at | |
| A_65_P02959 | |
| L0241G04-3 | |
| NM_011951 | |
| AF195850.1 | |
| I_957350 |
| Chromosome position | 6p21.3-p21.2 |
|---|---|
| 17 13.5 cM | |
| 20p12 |
| GO ID | 0004674 |
|---|---|
| 0004707 | |
| 0004708 | |
| 0004713 | |
| 0005524 | |
| 0005634 | |
| 0005737 | |
| 0006468 | |
| 0006928 | |
| 0006935 | |
| 0006950 | |
| 0007166 | |
| 0007243 | |
| 0008339 | |
| 0016740 | |
| 0019735 | |
| 0004682 | |
| GO:0004707 | |
| GO:0004691 | |
| GO:0004682 | |
| GO:0004713 | |
| GO:0005524 | |
| GO:0004674 | |
| GO:0004672 | |
| GO:0016301 | |
| GO:0016740 | |
| GO:0007243 | |
| GO:0006468 | |
| GO:0001525 | |
| GO:0005623 | |
| GO:0005829 | |
| GO:0004708 | |
| GO:0008339 | |
| GO:0006935 | |
| GO:0006950 | |
| GO:0007166 | |
| GO:0006928 | |
| GO:0019735 | |
| GO:0005737 | |
| GO:0005634 | |
| GO:0006960 | |
| 0004691 | |
| 0005829 | |
| 0000077 | |
| 0000922 | |
| 0001525 | |
| 0004672 | |
| 0005623 | |
| 0006006 | |
| 0016301 | |
| 0019395 | |
| 0045648 | |
| 0045944 | |
| 0000166 |
| Alias | P-38 |
|---|---|
| p38ALPHA | |
| stress-activated protein kinase 2A | |
| CSBP/p38 MAP kinase | |
| CSBP/p38 MAPK | |
| CSBP/p38 kinase | |
| MAPK14 | |
| PRKM14 | |
| cytokine suppressive anti-inflammatory drug binding protein I | |
| MAX-interacting protein II | |
| p38 kinase | |
| Crk1 | |
| CSBP1 | |
| CSPB I | |
| CSBP2 | |
| MAP kinase MXI2 | |
| p38 MAPK | |
| SAPK2A | |
| mitogen activated protein kinase 14 | |
| Csaids binding protein | |
| PRKM15 | |
| cytokine-supressive anti-inflammatory drug binding protein | |
| p38Hog | |
| MAX-interactive protein 2 | |
| MAX-interactive protein II | |
| MAP kinase p38 | |
| p38alpha mitogen-activated protein kinase | |
| cytokine suppressive anti-inflammatory drug binding protein 1 | |
| Exip | |
| p38alpha Exip | |
| CSBP I | |
| PRKM15s | |
| MAPK14s | |
| PRKM14s | |
| mgc102436 | |
| trna synthetase cofactor p38 | |
| CSAID binding protein | |
| CSPB1 | |
| cytokine suppressive anti-inflammatory drug binding protein | |
| MAPK p38 | |
| MAX-interacting protein 2 | |
| Mitogen-activated protein kinase p38 | |
| Mxi2 | |
| p38 MAP kinase | |
| p38 mitogen activated protein kinase | |
| p38 | |
| Scl12 | |
| Lil I | |
| Lil1 | |
| Lipid Level QTL 1 | |
| Lipid Level QTL I | |
| Serum cholesterol level QTL 12 | |
| Serum cholesterol level QTL XII | |
| RK | |
| Hog | |
| CSBP | |
| MAP kinase 2 | |
| reactive kinase | |
| p38MAPK | |
| p38-alpha | |
| mitogen-activated protein kinase 14 |
| Organism | Human |
|---|---|
| Mus musculus | |
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 11687663 |
|---|---|
| 9779826 | |
| 10943842 | |
| 10973481 | |
| 12466851 | |
| 12802337 | |
| 12808090 | |
| 12937170 | |
| 15509711 | |
| 10706854 | |
| 10838079 | |
| 10912793 | |
| 7997261 |
| LocusLink ID | 81649 |
|---|---|
| 1432 | |
| 12975 | |
| 26416 | |
| 326416 |
| FunctionalClass | cAMP-dependent protein kinase |
|---|---|
| protein kinase CK2 | |
| kinase | |
| protein kinase | |
| ATP binding | |
| MAP kinase | |
| MAP kinase kinase | |
| MP kinase | |
| nucleotide binding | |
| protein serine/threonine kinase | |
| protein-tyrosine kinase | |
| transferase |
| RGD ID | 70496 |
|---|---|
| 61407 |
| Hugo Symbol | MAPK14 |
|---|
| Unigene ID | Rn.88085 |
|---|---|
| Mm.311337 | |
| Hs.485233 | |
| Mm.347796 | |
| Hs.79107 | |
| Mm.4437 |
| KEGG pathway | MAPK signaling pathway |
|---|---|
| Toll-like receptor signaling pathway |
| Keyword | map kinase |
|---|---|
| ERK activator kinase | |
| tumor necrosis factor | |
| SAP kinase | |
| MAP kinase kinase kinase | |
| phospholipase C | |
| map kinases | |
| nucleus |
| GO Cellular Component | cell |
|---|---|
| spindle pole | |
| cytoplasm | |
| nucleus | |
| cytosol |
| GO Molecular Function | protein kinase CK2 activity |
|---|---|
| protein-tyrosine kinase activity | |
| ATP binding | |
| protein serine/threonine kinase activity | |
| protein kinase activity | |
| kinase activity | |
| transferase activity | |
| MAP kinase kinase activity | |
| MP kinase activity | |
| protein tyrosine kinase activity | |
| ATP binding activity | |
| MAP kinase activity | |
| cAMP-dependent protein kinase activity |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | p38 MAPK |
|---|---|
| CREB signaling | |
| p38 Signaling | |
| ACVR1B -> MADH7 signalling pathway | |
| ACVRL1 -> MADH5 signalling pathway | |
| NCAM1 -> TP53 signalling pathway | |
| NCAM1 -> CREB1 signalling pathway | |
| TNFRSF10B -> TP53 signalling pathway | |
| NGFR -> PAX6 signalling pathway | |
| NGFR -> CREB1 signalling pathway | |
| NTRK1 -> CREB1 signalling pathway | |
| NTRK2 -> CREB1 signalling pathway | |
| OPRD1 -> CREB1 signalling pathway | |
| TEK -> TCF3 signalling pathway | |
| TGFBR1 -> SP1 signalling pathway | |
| TGFBR1 -> MITF signalling pathway | |
| TLR2 -> HMG1 signalling pathway | |
| TLR4 -> CEBPA signalling pathway | |
| TLR4 -> EGR1 signalling pathway | |
| TNFRSF1A -> ZFP36 signalling pathway | |
| ADORA1 -> FOS signalling pathway | |
| AGER -> CREB1 signalling pathway | |
| AGTR1 -> TP53 signalling pathway | |
| AGTR1 -> CREB1 signalling pathway | |
| AGTR2 -> TP53 signalling pathway | |
| AGTR2 -> CREB1 signalling pathway | |
| ICAM1 -> TFAP2A signalling pathway | |
| ICAM1 -> CREB1 signalling pathway | |
| TNFRSF6 -> MYC signalling pathway | |
| TNFRSF6 -> FOS signalling pathway | |
| TNFRSF6 -> SP1 signalling pathway | |
| TNFRSF6 -> SRF signalling pathway | |
| TNFRSF6 -> CDX2 signalling pathway | |
| TNFRSF6 -> CREB1 signalling pathway | |
| TNFRSF6 -> DDIT3 signalling pathway | |
| IFNAR1 -> CDX2 signalling pathway | |
| IL4R -> GATA3 signalling pathway | |
| IL6R -> MITF signalling pathway | |
| IL6ST -> MYOG signalling pathway | |
| IL7R -> LEF1 signalling pathway | |
| IL7R -> TCF3 signalling pathway | |
| KLRG1 -> TP53 signalling pathway | |
| KLRG1 -> PAX6 signalling pathway | |
| KDR -> NFATC1 signalling pathway | |
| KDR -> ATF1 signalling pathway | |
| KDR -> CREB1 signalling pathway | |
| KIT -> TP53 signalling pathway | |
| KIT -> MITF signalling pathway | |
| LEPR -> TCF3 signalling pathway | |
| CD2 -> GATA3 signalling pathway | |
| CD4 -> NFATC2 signalling pathway | |
| CD4 -> TP53 signalling pathway | |
| CD4 -> GATA3 signalling pathway | |
| CD4 -> STAT6 signalling pathway | |
| TNFRSF7 -> TP53 signalling pathway | |
| CD28 -> GATA3 signalling pathway | |
| CD28 -> TCF3 signalling pathway | |
| CD28 -> CREB1 signalling pathway | |
| TNFRSF8 -> MYC signalling pathway | |
| TNFRSF8 -> TP53 signalling pathway | |
| CD38 -> MYBL1 signalling pathway | |
| CD38 -> TCF3 signalling pathway | |
| TNFRSF5 -> MYC signalling pathway | |
| TNFRSF5 -> TP53 signalling pathway | |
| TNFRSF5 -> TCF3 signalling pathway | |
| EPHA3 -> TP53 signalling pathway | |
| EPHA3 -> TCF3 signalling pathway | |
| EPHA4 -> STAT3 signalling pathway | |
| EPHA4 -> CTNNB1 signalling pathway | |
| ERBB2 -> TP53 signalling pathway | |
| ERBB2 -> SP1 signalling pathway | |
| ERBB2 -> MADH7 signalling pathway | |
| F2R -> CREB1 signalling pathway | |
| FCGR2B -> GATA4 signalling pathway | |
| FGFR1 -> CREB1 signalling pathway | |
| FGFR2 -> FOS signalling pathway | |
| FLT1 -> NFATC1 signalling pathway | |
| FLT1 -> CREB1 signalling pathway | |
| FSHR -> GATA4 signalling pathway | |
| SPN -> TP53 signalling pathway | |
| SPN -> TCF3 signalling pathway | |
| SSTR3 -> TP53 signalling pathway | |
| TACR1 -> CREB1 signalling pathway | |
| GPR9 -> CDX2 signalling pathway | |
| TBXA2R -> CREB1 signalling pathway | |
| CCR5 -> TP53 signalling pathway | |
| TAS2R13 -> ATF4 signalling pathway | |
| PTPRA -> TEAD1 signalling pathway | |
| PTPRC -> NFATC2 signalling pathway | |
| DRD1 -> CREB1 signalling pathway | |
| EDNRA -> CREB1 signalling pathway | |
| EDNRB -> CREB1 signalling pathway | |
| EGFR -> TP53 signalling pathway | |
| EPHA2 -> TP53 signalling pathway | |
| MC1R -> MADH6 signalling pathway | |
| MC1R -> MADH7 signalling pathway | |
| MC1R -> MITF signalling pathway | |
| MET -> TP53 signalling pathway | |
| MET -> MAX signalling pathway | |
| AGT-LRP2 | |
| BDNF-NCAM1 | |
| BDNF-NGFR | |
| BDNF-NTRK1 | |
| BDNF-NTRK2 | |
| BDNF-NTRK3 | |
| BMP2-ACVR1 | |
| BMP2-ACVR2 | |
| BMP2-BMPR1A | |
| BMP2-BMPR1B | |
| BMP2-BMPR2 | |
| BMP4-ACVR1 | |
| BMP4-BMPR1A | |
| BMP4-BMPR1B | |
| BMP4-BMPR2 | |
| BMP7-ACVR1 | |
| BMP7-ACVR2 | |
| BMP7-ACVR2B | |
| BMP7-BMPR1A | |
| BMP7-BMPR1B | |
| BMP7-BMPR2 | |
| BTC-EGFR | |
| CCL2-CD4 | |
| CCL22-VCAM1 | |
| CCL4-CD4 | |
| CCL4-TNFRSF8 | |
| CSF1-CSF1R | |
| CSF1-IL6R | |
| CSF1-TNFRSF5 | |
| CSF2-CSF2RA | |
| CSF3-CSF3R | |
| CSF3-IL6R | |
| DTR-CD44 | |
| DTR-EGFR | |
| DTR-ERBB4 | |
| EGF-EGFR | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| EPO-EPOR | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| F2-THBD | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| GH1-GHR | |
| GH1-IGF1R | |
| GH1-PRLR | |
| HGF-CD44 | |
| HGF-FGFR2 | |
| HGF-IL6R | |
| HGF-MET | |
| IFNA1-CR2 | |
| IFNA1-IFNAR1 | |
| IFNA1-IFNAR2 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF1R | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IL10-IL10RA | |
| IL10-TNFRSF7 | |
| IL13-IL13RA1 | |
| IL13-IL13RA2 | |
| IL13-IL2RG | |
| IL13-IL4R | |
| IL15-IL15RA | |
| IL15-IL2RB | |
| IL15-IL2RG | |
| IL16-CD4 | |
| IL17-IL17R | |
| IL1A-IL1R1 | |
| IL1A-IL1RAP | |
| IL1B-HLA-DRB1 | |
| IL1B-IL1R1 | |
| IL1B-IL1RAP | |
| IL1B-IL6R | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL2RG | |
| IL2-IL4R | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| IL5-IL5RA | |
| IL5-IL6ST | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| IL7-IL2RG | |
| IL7-IL7R | |
| INHBA-ACVR1B | |
| INHBA-ACVR2 | |
| INHBA-ACVR2B | |
| INHBA-ACVRL1 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-IGF1R | |
| INS-TFRC | |
| KITLG-KIT | |
| LEP-LEPR | |
| LEP-LRP2 | |
| LIF-IGF2R | |
| LIF-IL6ST | |
| LIF-LIFR | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NPPA-NPTXR | |
| NRG1-CD44 | |
| NRG1-EGFR | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| NRG2-ERBB3 | |
| NTF3-CNTFR | |
| NTF3-NGFR | |
| NTF3-NTRK1 | |
| NTF3-NTRK2 | |
| NTF3-NTRK3 | |
| NTN1-HLA-C | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PGF-FLT1 | |
| PGF-KDR | |
| PTH-IL6ST | |
| SDF1-CD4 | |
| SDF1-IL6ST | |
| TAC1-TNFRSF11B | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| THBS1-CD36 | |
| THBS1-ITGB1 | |
| THBS1-VLDLR | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1A | |
| TNF-TNFRSF1B | |
| TNF-TNFRSF6 | |
| TNFSF10-TNFRSF10A | |
| TNFSF10-TNFRSF10B | |
| TNFSF10-TNFRSF1A | |
| TNFSF10-TNFRSF6 | |
| TNFSF11-TNFRSF11A | |
| TNFSF11-TNFRSF11B | |
| TNFSF13B-TNFRSF13B | |
| TNFSF13B-TNFRSF13C | |
| TNFSF13B-TNFRSF17 | |
| TNFSF5-CD28 | |
| TNFSF5-CD80 | |
| TNFSF5-TNFRSF5 | |
| TNFSF5-TNFRSF6 | |
| TNFSF5-TNFRSF7 | |
| TNFSF5-TNFRSF8 | |
| TNFSF6-TNFRSF6 | |
| VEGF-CD44 | |
| VEGF-EGFR | |
| VEGF-FLT1 | |
| VEGF-FLT4 | |
| VEGF-GPC1 | |
| VEGF-IL1R1 | |
| VEGF-KDR | |
| DuPont 2 | |
| DuPont 3 | |
| CLA Grow | |
| Ben Common regulators | |
| PPAR all | |
| PPARalpha | |
| PGC1alpha | |
| ERalpha | |
| GR | |
| TR | |
| NR common regulators | |
| Donna's proteomics |
| GO Biological Process | antimicrobial humoral response (sensu Invertebrata) |
|---|---|
| DNA damage checkpoint | |
| angiogenesis | |
| fatty acid oxidation | |
| glucose metabolism | |
| positive regulation of erythrocyte differentiation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| antimicrobial humoral response (sensu Vertebrata) | |
| cell motility | |
| cell surface receptor linked signal transduction | |
| chemotaxis | |
| protein amino acid phosphorylation | |
| protein kinase cascade | |
| response to stress |
| Group | Kinases |
|---|
| EC Number | 2.7.1.37 |
|---|---|
| 2.7.1.- |
| State | isoform 1 |
|---|---|
| isoform 2 | |
| isoform 3 | |
| isoform 4 | |
| p |
| State Description | Transcript Variant: This variant (1) encodes the longest isoform (1). |
|---|---|
| Transcript Variant: This variant (2) contains a different segment within the coding region when compared to variant 1. The translation frame remains the same, and the resulting isoform 2 has an internal segment different from that of isoform 1. | |
| Transcript Variant: This variant (3) contains a different internal segment within the coding region, and a different 3' coding region as well as a different 3' UTR, when compared to variant 1. It thus encodes an isoform that has a different internal se... | |
| Transcript Variant: This variant (4) contains a different internal segment when compared to variant 1. It thus encodes an isoform that has a different and shorter internal segment, as compared to isoform 1. |
| MGI ID | 1346865 |
|---|
| Swiss-Prot Accession | Q16539 |
|---|
| OMIM ID | 600289 |
|---|---|
| 61407 | |
| OMIM:600289 |
| Source | BIND |
|---|---|
| ResNet | |
| Curated |