| Name | TP53 |
|---|---|
| Description | tumor protein p53 (Li-Fraumeni syndrome) |
| Owner | Public |
| URN | urn:agi-llid:7157 |
| Connectivity | 961 |
| Notes | Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. |
| Hugo ID | 11998 |
| Microarray ID | 1367830_a_at |
|---|---|
| 1367831_at | |
| 1370752_a_at | |
| x13058_at | |
| A_42_P619917 | |
| 104154_at | |
| 104275_g_at | |
| 134478_r_at | |
| 1426538_a_at | |
| 1427739_a_at | |
| 168098_r_at | |
| k01700-2_s_at | |
| A_51_P184738 | |
| X01405 | |
| K03199 | |
| 201746_at | |
| 211300_s_at | |
| 1939_at | |
| 1974_s_at | |
| M22898_at | |
| A_23_P26807 | |
| A_14_P104532 | |
| A_14_P122951 | |
| A_14_P100302 | |
| A_23_P26810 | |
| M241 | |
| OR0723 | |
| R553 | |
| 38 | |
| OH7728 | |
| 326846_Rn | |
| 1438808_at | |
| 136996_r_at | |
| 168990_r_at | |
| 1457623_x_at | |
| Msa.1049.0_at | |
| A_65_P14116 | |
| H3026D07-5 | |
| NM_011640 | |
| A_65_P10093 | |
| L0249H08-3 | |
| 1880_AT | |
| 31618_AT | |
| I_958219 |
| Chromosome position | 11 39.0 cM |
|---|---|
| 17p13.1 | |
| 10q24 |
| GO ID | 0003700 |
|---|---|
| 0004518 | |
| 0005507 | |
| 0005515 | |
| GO:0005515 | |
| GO:0003702 | |
| GO:0003677 | |
| GO:0003700 | |
| GO:0006350 | |
| GO:0000060 | |
| GO:0006355 | |
| GO:0006915 | |
| GO:0006357 | |
| GO:0030308 | |
| GO:0045786 | |
| GO:0030330 | |
| GO:0005829 | |
| GO:0005737 | |
| GO:0005634 | |
| GO:0004518 | |
| GO:0008628 | |
| GO:0008630 | |
| GO:0000075 | |
| GO:0006281 | |
| GO:0006310 | |
| GO:0000232 | |
| GO:0045182 | |
| GO:0008151 | |
| GO:0008181 | |
| GO:0007048 | |
| 0003702 | |
| 0006357 | |
| 0005524 | |
| 0005730 | |
| 0005739 | |
| 0006284 | |
| 0006289 | |
| 0006310 | |
| 0005634 | |
| 0005657 | |
| 0005737 | |
| 0005829 | |
| 0006974 | |
| 0007049 | |
| 0008156 | |
| 0009411 | |
| 0010165 | |
| 0030330 | |
| 0042127 | |
| 0042771 | |
| 0043066 | |
| 0048147 | |
| 0000060 | |
| 0003677 | |
| 0006350 | |
| 0006355 | |
| 0006915 | |
| 0007050 | |
| 0007569 | |
| 0008270 | |
| 0008283 | |
| 0008628 | |
| 0008630 | |
| 0008635 | |
| 0030154 | |
| 0030308 | |
| 0045786 | |
| 0046872 | |
| 0046902 | |
| 0046982 | |
| 0051097 | |
| 0051262 | |
| 0000075 | |
| 0000739 |
| Alias | Trp53 |
|---|---|
| similar to transformation related protein 53 | |
| similar to p53 alternative splice isoform p35/HAS | |
| Tp53 protein | |
| (P53) | |
| similar to p53 alternative splice isoform p35/HAS [Rattus norvegicus] | |
| similar to transformation related protein 53 [Mus musculus] | |
| similar to Cellular tumor antigen p53 (Tumor suppressor p53) | |
| TRP53 protein | |
| p53 | |
| TRP53 gene | |
| P-53 | |
| Tumor suppressor p53 | |
| TRP53 (p53) | |
| cys51stop | |
| p53 tumor suppressor | |
| Cellular tumor antigen p53 | |
| Phosphoprotein p53 | |
| TP53 | |
| transformation related protein 53 | |
| tumor protein p53 | |
| tumor protein p53 (Li-Fraumeni syndrome) | |
| p53 alternative splice isoform p35/HAS | |
| P53_HUMAN |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus | |
| Human | |
| murine | |
| rat | |
| mouse |
| LocusLink ID | 24842 |
|---|---|
| 7157 | |
| 22059 | |
| 289761 | |
| 224883 | |
| 301300 |
| FunctionalClass | RNA polymerase II transcription factor |
|---|---|
| DNA binding | |
| ATP binding | |
| DNA strand annealing | |
| copper ion binding | |
| metal ion binding | |
| nuclease | |
| protein binding | |
| protein heterodimerization | |
| transcription factor | |
| zinc ion binding |
| RGD ID | 3889 |
|---|
| Hugo Symbol | TP53 |
|---|
| Unigene ID | Rn.54443 |
|---|---|
| Mm.222 | |
| Hs.408312 | |
| Hs.1846 |
| Keyword | nucleus |
|---|---|
| exonuclease | |
| RAS small monomeric GTPase | |
| deacetylation | |
| transcription activating factor | |
| anti-oncogene | |
| nuclear body | |
| cytoplasm | |
| 14-3-3 | |
| ubiquitin | |
| transcription factor | |
| tumor suppressor | |
| cell cycle regulator | |
| telomerase | |
| DNA binding activity | |
| antioncogene | |
| telomerase activity | |
| oncogene | |
| nitroreductase | |
| nuclei | |
| RNA | |
| DNA |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| nucleus | |
| replication fork | |
| mitochondrion | |
| nucleolus | |
| nuclear interphase chromosome |
| GO Molecular Function | protein binding |
|---|---|
| RNA polymerase II transcription factor activity | |
| DNA binding | |
| transcription factor activity | |
| nuclease activity | |
| DNA binding activity | |
| protein binding activity | |
| translation regulator activity | |
| tumor suppressor | |
| nuclease | |
| transcription factor |
| Cell Localization | Nucleus |
|---|
| Pathway | Jnk-mapk |
|---|---|
| ATM signaling | |
| SAPK-JNK Signaling | |
| Apoptosis | |
| Mitochondrial control of Apoptosis | |
| p53 Signaling | |
| RB Tumor Suppressor | |
| NCAM1 -> TP53 signalling pathway | |
| TNFRSF10B -> TP53 signalling pathway | |
| NGFR -> TP53 signalling pathway | |
| NOTCH1 -> TP53 signalling pathway | |
| NTRK1 -> TP53 signalling pathway | |
| AGTR1 -> TP53 signalling pathway | |
| AGTR2 -> TP53 signalling pathway | |
| TNFRSF6 -> TP53 signalling pathway | |
| IGF1R -> TP53 signalling pathway | |
| KLRG1 -> TP53 signalling pathway | |
| DDR1 -> TP53 signalling pathway | |
| KIT -> TP53 signalling pathway | |
| CD4 -> TP53 signalling pathway | |
| TNFRSF7 -> TP53 signalling pathway | |
| TNFRSF8 -> TP53 signalling pathway | |
| TNFRSF5 -> TP53 signalling pathway | |
| EPHA3 -> TP53 signalling pathway | |
| ERBB2 -> TP53 signalling pathway | |
| SPN -> TP53 signalling pathway | |
| GCGR -> TP53 signalling pathway | |
| SSTR2 -> TP53 signalling pathway | |
| SSTR3 -> TP53 signalling pathway | |
| CCR5 -> TP53 signalling pathway | |
| EGFR -> TP53 signalling pathway | |
| EPHA2 -> TP53 signalling pathway | |
| MET -> TP53 signalling pathway | |
| AGT-LRP2 | |
| C3-CR2 | |
| CD86-CR2 | |
| CSF2-CSF2RA | |
| CTF1-IL6ST | |
| CYR61-ITGAV | |
| DTR-CD44 | |
| DTR-EGFR | |
| DTR-ERBB4 | |
| EGF-EGFR | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| EPO-EPOR | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| GH1-GHR | |
| GH1-IGF1R | |
| GH1-PRLR | |
| GRO1-EGFR | |
| HGF-CD44 | |
| HGF-FGFR2 | |
| HGF-IL6R | |
| HGF-MET | |
| IFNA1-CR2 | |
| IFNA1-IFNAR1 | |
| IFNA1-IFNAR2 | |
| IFNB1-IFNAR1 | |
| IFNB1-IFNAR2 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF1R | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL2RG | |
| IL2-IL4R | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| INHBA-ACVR1B | |
| INHBA-ACVR2 | |
| INHBA-ACVR2B | |
| INHBA-ACVRL1 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-IGF1R | |
| INS-TFRC | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NPPA-NPTXR | |
| NRG1-CD44 | |
| NRG1-EGFR | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PF4-THBD | |
| TAC1-TNFRSF11B | |
| TGFA-EGFR | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1A | |
| TNF-TNFRSF1B | |
| TNF-TNFRSF6 | |
| TNFSF10-TNFRSF10A | |
| TNFSF10-TNFRSF10B | |
| TNFSF10-TNFRSF1A | |
| TNFSF10-TNFRSF6 | |
| TNFSF4-TNFRSF6 | |
| TNFSF5-TNFRSF6 | |
| TNFSF6-TNFRSF6 | |
| TNFSF7-TNFRSF6 | |
| TNFSF8-TNFRSF6 | |
| TNFSF9-TNFRSF6 | |
| VEGF-CD44 | |
| VEGF-EGFR | |
| VEGF-FLT1 | |
| VEGF-FLT4 | |
| VEGF-GPC1 | |
| VEGF-IL1R1 | |
| VEGF-KDR | |
| WNT1-LRP5 | |
| WNT1-LRP6 | |
| WNT1-ROR2 | |
| DuPont 2 | |
| DuPont 3 | |
| DuPont 4 | |
| Volcano 2 | |
| Ben Common regulators | |
| LXR | |
| AR | |
| ERalpha | |
| GR | |
| HNF4a | |
| TR | |
| NR common targets | |
| NR common regulators | |
| DuPont 4 of 6 common regulators | |
| Donna's proteomics |
| Compartment | void |
|---|---|
| nucleus | |
| DNA |
| GO Biological Process | DNA damage response, signal transduction by p53 class mediator |
|---|---|
| DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | |
| cell cycle | |
| negative regulation of DNA replication | |
| negative regulation of apoptosis | |
| negative regulation of fibroblast proliferation | |
| protein-nucleus import, translocation | |
| regulation of cell proliferation | |
| response to DNA damage stimulus | |
| response to UV | |
| response to X-ray | |
| DNA damage response, signal transduction resulting in induction of apoptosis | |
| DNA recombination | |
| apoptosis | |
| base-excision repair | |
| caspase activation via cytochrome c | |
| cell aging | |
| cell cycle arrest | |
| cell cycle checkpoint | |
| cell differentiation | |
| cell proliferation | |
| induction of apoptosis by hormones | |
| negative regulation of cell growth | |
| negative regulation of helicase | |
| negative regulation of progression through cell cycle | |
| nucleotide-excision repair | |
| protein tetramerization | |
| regulation of mitochondrial membrane permeability | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| regulation of transcription from RNA polymerase II promoter | |
| DNA repair | |
| cell growth and/or maintenance | |
| p53-mediated DNA damage response | |
| induction of apoptosis by DNA damage | |
| oncogenesis | |
| negative regulation of cell cycle | |
| regulation of transcription from Pol II promoter | |
| negative regulation of helicase activity |
| Group | Transcription factors |
|---|
| Proteome Organismal Role | Cell death/Apoptosis |
|---|
| RefSeq ACCNUM | NP_000537 |
|---|
| Proteome Subcellular Localization | Nuclear |
|---|
| Proteome Biochemical Function | Nuclease [endo, exo, ribo, deoxyribo] |
|---|---|
| Hydrolase | |
| Inhibitor or repressor | |
| DNA-binding protein |
| State | p |
|---|---|
| unphosphorylated | |
| u |
| Proteome Cellular Role | DNA repair |
|---|
| MGI ID | 98834 |
|---|
| Swiss-Prot Accession | P04637 |
|---|
| OMIM ID | 191170 |
|---|---|
| 202300 | |
| 114480 | |
| 114500 | |
| 114550 | |
| 151623 | |
| 161550 | |
| 260350 | |
| OMIM:191170 | |
| OMIM:202300 | |
| OMIM:114480 | |
| OMIM:114500 | |
| OMIM:114550 | |
| OMIM:151623 | |
| OMIM:161550 | |
| OMIM:260350 |
| Source | Curated |
|---|---|
| BIND | |
| ResNet |