| Name | SGN2 |
|---|---|
| Description | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) |
| Owner | Public |
| URN | urn:agi-llid:9318 |
| Connectivity | 6 |
| Notes | Alien and Sin3A reside together in vivo with the vitamin D3 receptor on the human 24-hydroxylase (CYP24) promoter containing vitamin D3 response elements by chromatin immunoprecipitation. Demonstrate Alien-MLK2 interaction and also show that MLK2 is able to phosphorylate Alien; Alien, DAX-1 and thyroid hormone receptor mediated transcriptional silencing is strongly enhanced in the presence of active MLK2. |
| Chromosome position | 2 70.0 cM |
|---|---|
| 15q21.2 | |
| 3q36 |
| GO ID | 0016564 |
|---|---|
| 0030182 | |
| 0004871 | |
| 0005515 | |
| 0005737 | |
| 0006366 | |
| 0007165 | |
| 0008180 | |
| 0004872 | |
| 0003714 | |
| 0005634 | |
| 0008283 | |
| 0016481 |
| Alias | alien homologue |
|---|---|
| alien-like | |
| C85265 | |
| COPS2 | |
| COP9 (constitutive photomorphogenic) homolog, subunit | |
| constitutive photomorphogenic, subunit 2 | |
| expressed sequence C85265 | |
| COP9 (constitutive photomorphogenic) homolog, subunit II | |
| COP9 (constitutive photomorphogenic, subunit II | |
| SGN2 | |
| COP9 (constitutive photomorphogenic) homolog, subunit 2 | |
| TRIP15 | |
| COP9 (constitutive photomorphogenic, subunit 2 | |
| TRIP15/CSN2 | |
| thyroid receptor interacting protein XV | |
| COP9 subunit II | |
| COP9 subunit 2 | |
| thyroid receptor interacting protein 15 | |
| C85265s | |
| TRIP15s |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 12524175 |
|---|---|
| 7776974 | |
| 9535219 | |
| 12466851 | |
| 12606288 | |
| 12972599 | |
| 15062575 | |
| 9707402 |
| LocusLink ID | 261736 |
|---|---|
| 98909 | |
| 9318 | |
| 12848 | |
| 97013 |
| FunctionalClass | protein binding |
|---|---|
| signal transducer | |
| receptor | |
| transcriptional repressor | |
| transcription corepressor |
| GO Cellular Component | nucleus |
|---|---|
| cytoplasm | |
| signalosome complex |
| Pathway | TR |
|---|
| GO Biological Process | cell proliferation |
|---|---|
| negative regulation of transcription | |
| signal transduction | |
| transcription from RNA polymerase II promoter | |
| neuron differentiation |
| Source | Curated |
|---|