| Name | MEF2A |
|---|---|
| Description | myocyte enhancer factor 2A |
| Owner | Public |
| URN | urn:agi-llid:4205 |
| Connectivity | 94 |
| Notes | The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM] |
| Hugo ID | 6993 |
| Microarray ID | 242176_at |
|---|---|
| U49020_cds2_s_at | |
| x68505_s_at | |
| A_23_P353652 | |
| A_14_P117082 | |
| A_14_P100875 | |
| A_14_P108649 | |
| A_24_P1731 | |
| A_32_P26555 | |
| A_23_P205939 | |
| H334 | |
| OH2158 | |
| V169 | |
| 1421252_a_at | |
| 1425426_a_at | |
| 1427186_a_at | |
| 93852_at | |
| u30823_s_at | |
| A_51_P132044 | |
| X68505 | |
| 214684_at | |
| 212535_at | |
| 44865_s_at | |
| 208328_s_at |
| Chromosome position | 15q26 |
|---|---|
| 7 33.0 cM |
| GO ID | 0003700 |
|---|---|
| 0003713 | |
| 0005634 | |
| 0006350 | |
| 0006355 | |
| 0006366 | |
| 0007517 | |
| 0003677 |
| Alias | MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) |
|---|---|
| MEF2 | |
| Mef2a | |
| myocyte enhancer factor 2A | |
| RSRFC4 | |
| Serum response factor-like protein 1 | |
| A430079H05Rik | |
| MADS box transcription enhancer factor 2A | |
| RIKEN cDNA A430079H05 gene | |
| Myocite enhancer factor 2 | |
| Myocyte-specific enhancer factor 2A | |
| ADCAD1 | |
| RSRFC9 | |
| Serum response factor-like protein I | |
| RSRFC4s | |
| ADCAD1s | |
| RSRFC9s |
| Organism | Human |
|---|---|
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 1516833 |
|---|---|
| 8575763 | |
| 12130539 |
| LocusLink ID | 4205 |
|---|---|
| 320979 | |
| 17258 |
| FunctionalClass | transcription coactivator |
|---|---|
| transcription factor | |
| DNA binding |
| Hugo Symbol | MEF2A |
|---|
| Unigene ID | Mm.132788 |
|---|---|
| Hs.268675 | |
| Hs.415033 |
| GO Cellular Component | nucleus |
|---|
| Cell Localization | Nucleus |
|---|
| Pathway | Jnk-mapk |
|---|---|
| p38 MAPK | |
| MAPK signaling | |
| Control of skeletal myogenesis | |
| p38 Signaling | |
| AGT-LRP2 | |
| BDNF-NCAM1 | |
| BDNF-NGFR | |
| BDNF-NTRK1 | |
| BDNF-NTRK2 | |
| BDNF-NTRK3 | |
| BMP2-ACVR1 | |
| BMP2-ACVR2 | |
| BMP2-BMPR1A | |
| BMP2-BMPR1B | |
| BMP2-BMPR2 | |
| CSF3-CSF3R | |
| CSF3-IL6R | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| PGC1alpha | |
| TR | |
| PPARalpha large |
| GO Biological Process | transcription from Pol II promoter |
|---|---|
| muscle development | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter |
| Group | Transcription factors |
|---|
| State | isoform 1 |
|---|---|
| isoform 2 |
| MGI ID | 99532 |
|---|
| Swiss-Prot Accession | Q02078 |
|---|
| OMIM ID | 600660 |
|---|---|
| 608320 | |
| OMIM:600660 | |
| OMIM:608320 |
| Source | ResNet |
|---|---|
| Curated |