| Name | Pbx1 |
|---|---|
| Description | pre-B-cell leukemia transcription factor 1 |
| Owner | Public |
| URN | urn:agi-llid:5087 |
| Connectivity | 29 |
| Notes | E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. E2a-Pbx1 and Bmi-1 are likely to play a role in the pathogenesis of human lymphoid leukemias through downregulation of the INK4A-ARF gene. HoxD9 and Pbx1 are inappropriately expressed in most human esophageal squamous cell carcinoma. Understanding the role of Hox genes in esophageal epithelial cell carcinogenesis may not only augment early detection but also offer possiblde treatment. In Mice, Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. In pancreatic exocrine tissue from obese non-diabetic subjects with increased islet mass, we found that Pbx-1 and Pdx-1 were up-regulated (5.9+/-1.2 and 2.4+/-0.6 versus non-obese). PBX1 complexed with HOXA9 and DNA, so that the posterior Hox hexapeptide adopts an altered conformation. Pbx1 interacts with Pax6 and enhances its transcriptional activity. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human Pbx1. These studies demonstrate that the homeodomain proteins, MEIS1, PBX1B, and PBX2, play an important role in megakaryocytic gene expression. |
| Microarray ID | 1449542_at |
|---|---|
| 94803_at | |
| af020197_at | |
| A_51_P413238 | |
| A_52_P543460 | |
| M86546 | |
| 32063_at | |
| 205253_at | |
| 212148_at | |
| 212151_at | |
| M86546_at | |
| 84235_at | |
| A_23_P62948 | |
| A_14_P109901 | |
| A_14_P108826 | |
| A_14_P135647 | |
| A_14_P131780 | |
| A_14_P118233 | |
| A_14_P119839 | |
| A_23_P62953 | |
| B201 | |
| OH7936 |
| Chromosome position | 1q23 |
|---|---|
| 13q24 | |
| 1 88.1 cM |
| GO ID | 0001655 |
|---|---|
| 0001658 | |
| 0003677 | |
| 0005667 | |
| 0005737 | |
| 0006350 | |
| 0009887 | |
| 0030325 | |
| 0045449 | |
| 0003700 | |
| 0005515 | |
| 0005634 | |
| 0006355 | |
| 0006366 | |
| 0006700 | |
| 0007548 | |
| 0009790 | |
| 0030902 | |
| 0045898 |
| Alias | RIKEN cDNA D230003C07 gene |
|---|---|
| Homeobox protein PRL | |
| dkfzp686b09108 | |
| Homeobox protein PBX1 | |
| Pbx1 | |
| D230003C07Rik | |
| pre-B-cell leukemia transcription factor I | |
| pre-B-cell leukemia transcription factor 1 | |
| Homeobox protein PBX I | |
| Pbx I | |
| Pbx1a |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 10052460 |
|---|---|
| 10500199 | |
| 11010815 | |
| 11912494 | |
| 12591246 | |
| 12724421 | |
| 14595835 | |
| 9315626 |
| LocusLink ID | 18514 |
|---|---|
| 320741 | |
| 304947 | |
| 5087 |
| FunctionalClass | DNA binding |
|---|---|
| protein binding | |
| transcription factor |
| GO Cellular Component | cytoplasm |
|---|---|
| transcription factor complex | |
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | TR |
|---|
| GO Biological Process | adrenal gland development |
|---|---|
| organogenesis | |
| regulation of transcription | |
| transcription | |
| ureteric bud branching | |
| urogenital system development | |
| C21-steroid hormone biosynthesis | |
| embryonic development | |
| hindbrain development | |
| regulation of transcription, DNA-dependent | |
| regulation of transcriptional preinitiation complex formation | |
| sex differentiation | |
| transcription from RNA polymerase II promoter |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|