| Name | STAT5A |
|---|---|
| Description | signal transducer and activator of transcription 5A |
| Owner | Public |
| URN | urn:agi-llid:6776 |
| Connectivity | 207 |
| Notes | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. |
| Hugo ID | 11366 |
| Microarray ID | 1368231_at |
|---|---|
| u24175_at | |
| A_42_P652586 | |
| 100422_i_at | |
| 100423_f_at | |
| 1421469_a_at | |
| 1450259_a_at | |
| u21103_s_at | |
| A_51_P152765 | |
| L41142 | |
| 40458_at | |
| 75183_at | |
| 203010_at | |
| 506_s_at | |
| U43185_s_at | |
| A_23_P406977 | |
| A_14_P118146 | |
| A_14_P112071 | |
| A_14_P103776 | |
| A_23_P207367 | |
| A_24_P173088 | |
| M586 | |
| OR2189 | |
| OH9101 | |
| RA0749 | |
| RA0752 | |
| OR2131 | |
| X91988_at | |
| U25137_at | |
| K0315G05-3 | |
| NM_011488 | |
| 224026_Rn | |
| Msa.1674.0_at | |
| A_65_P16292 | |
| 472_AT | |
| 473_G_AT | |
| NM_003152.2 | |
| A_23_P100788 | |
| I_960020 |
| Chromosome position | 17q11.2 |
|---|---|
| 10q32.1 | |
| 11 60.5 cM |
| GO ID | GO:0005507 |
|---|---|
| GO:0005489 | |
| GO:0003677 | |
| GO:0004871 | |
| GO:0003700 | |
| GO:0006118 | |
| GO:0006355 | |
| GO:0007242 | |
| GO:0007165 | |
| GO:0005634 | |
| GO:0007595 | |
| GO:0030155 | |
| GO:0030856 | |
| GO:0007259 | |
| GO:0006955 | |
| GO:0006357 | |
| GO:0045182 | |
| 0030155 | |
| 0030856 | |
| 0030879 | |
| 0040018 | |
| 0042104 | |
| 0043029 | |
| 0043066 | |
| 0045086 | |
| 0045579 | |
| 0045647 | |
| 0045885 | |
| 0045931 | |
| 0045944 | |
| 0046543 | |
| 0046544 | |
| 0050729 | |
| 0003690 | |
| 0005489 | |
| 0005507 | |
| 0006118 | |
| 0003700 | |
| 0004871 | |
| 0005509 | |
| 0005634 | |
| 0006350 | |
| 0006357 | |
| 0006955 | |
| 0007242 | |
| 0007259 | |
| 0001553 | |
| 0001779 | |
| 0003677 | |
| 0005515 | |
| 0005737 | |
| 0006355 | |
| 0007165 | |
| 0007565 | |
| 0007595 | |
| 0008284 | |
| 0019218 | |
| 0019221 | |
| 0019915 |
| Alias | 9430047L24Rik |
|---|---|
| RIKEN cDNA 9430047L24 gene | |
| signal transducer and activator of transcription 5A | |
| STAT5 | |
| Stat5a |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus | |
| Human |
| MedLine Reference | 10072077 |
|---|---|
| 10979977 | |
| 11706048 | |
| 12147240 | |
| 12198240 | |
| 12634107 | |
| 14522949 | |
| 15471942 | |
| 9630227 | |
| 8584036 | |
| 7719937 | |
| 8631883 |
| LocusLink ID | 24918 |
|---|---|
| 103612 | |
| 6776 | |
| 20850 | |
| 320850 |
| FunctionalClass | copper ion binding |
|---|---|
| double-stranded DNA binding | |
| electron transporter | |
| calcium ion binding | |
| signal transducer | |
| transcription factor | |
| DNA binding | |
| protein binding |
| RGD ID | 3773 |
|---|
| Hugo Symbol | STAT5A |
|---|
| Unigene ID | Rn.11355 |
|---|---|
| Mm.277403 | |
| Hs.437058 | |
| Mm.4697 | |
| Hs.167503 |
| KEGG pathway | Jak-STAT signaling pathway |
|---|
| Keyword | nucleus |
|---|---|
| docking protein | |
| transcription factor | |
| DNA binding activity | |
| nuclei | |
| DNA |
| GO Cellular Component | nucleus |
|---|---|
| cytoplasm |
| GO Molecular Function | copper ion binding |
|---|---|
| electron transporter activity | |
| DNA binding | |
| signal transducer activity | |
| transcription factor activity | |
| translation regulator activity |
| Cell Localization | Nucleus |
|---|
| Pathway | IL-3 signaling |
|---|---|
| IL-2 signaling | |
| Erythropoietin signaling | |
| TPO | |
| Prolactin | |
| PDGFRB | |
| Leptin | |
| IL9 | |
| IL7 | |
| IL5 | |
| IL3 | |
| IL27 | |
| IL2 | |
| IL15 | |
| IL10 | |
| Growth Hormone | |
| GM-CSF | |
| EPO | |
| EGF | |
| NTRK1 -> STAT5A signalling pathway | |
| NTRK3 -> STAT5A signalling pathway | |
| TEK -> STAT5A signalling pathway | |
| IFNGR1 -> STAT5A signalling pathway | |
| IGF1R -> STAT5A signalling pathway | |
| IL2RB -> STAT5A signalling pathway | |
| IL2RG -> STAT5A signalling pathway | |
| IL3RA -> STAT5A signalling pathway | |
| IL4R -> STAT5A signalling pathway | |
| IL6ST -> STAT5A signalling pathway | |
| IL7R -> STAT5A signalling pathway | |
| IL9R -> STAT5A signalling pathway | |
| IL10RA -> STAT5A signalling pathway | |
| KIT -> STAT5A signalling pathway | |
| LIFR -> STAT5A signalling pathway | |
| CD4 -> STAT5A signalling pathway | |
| TNFRSF5 -> STAT5A signalling pathway | |
| EPHA3 -> STAT5A signalling pathway | |
| EPOR -> STAT5A signalling pathway | |
| ERBB2 -> STAT5A signalling pathway | |
| ERBB4 -> STAT5A signalling pathway | |
| CRL3 -> STAT5A signalling pathway | |
| FCGR3A -> STAT5A signalling pathway | |
| FGFR1 -> STAT5A signalling pathway | |
| FGFR3 -> STAT5A signalling pathway | |
| FLT3 -> STAT5A signalling pathway | |
| GHR -> STAT5A signalling pathway | |
| CCR5 -> STAT5A signalling pathway | |
| IL21R -> STAT5A signalling pathway | |
| CSF2RA -> STAT5A signalling pathway | |
| CSF3R -> STAT5A signalling pathway | |
| PRLR -> STAT5A signalling pathway | |
| EGFR -> STAT5A signalling pathway | |
| MET -> STAT5A signalling pathway | |
| MPL -> STAT5A signalling pathway | |
| AGT-LRP2 | |
| AREG-EGFR | |
| BTC-EGFR | |
| CCL19-IL2RB | |
| CSF1-CSF1R | |
| CSF1-IL6R | |
| CSF1-TNFRSF5 | |
| CSF2-CSF2RA | |
| CSF3-CSF3R | |
| CSF3-IL6R | |
| CSH1-GHR | |
| CTF1-IL6ST | |
| DTR-CD44 | |
| DTR-EGFR | |
| DTR-ERBB4 | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| EPO-EPOR | |
| EREG-EGFR | |
| GH1-GHR | |
| GH1-IGF1R | |
| GH1-PRLR | |
| GRO1-EGFR | |
| HGF-CD44 | |
| HGF-FGFR2 | |
| HGF-IL6R | |
| HGF-MET | |
| IFNA1-CR2 | |
| IFNA1-IFNAR1 | |
| IFNA1-IFNAR2 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IL10-IL10RA | |
| IL10-TNFRSF7 | |
| IL11-IL6R | |
| IL11-IL6ST | |
| IL13-IL13RA1 | |
| IL13-IL13RA2 | |
| IL13-IL2RG | |
| IL13-IL4R | |
| IL15-IL15RA | |
| IL15-IL2RB | |
| IL15-IL2RG | |
| IL17D-WSX1 | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL4R | |
| IL21-IL2RG | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| IL5-IL5RA | |
| IL5-IL6ST | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| IL7-IL2RG | |
| IL7-IL7R | |
| IL9-IL9R | |
| INHBA-ACVR1B | |
| INHBA-ACVR2 | |
| INHBA-ACVR2B | |
| INHBA-ACVRL1 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| KITLG-KIT | |
| LEP-LEPR | |
| LEP-LRP2 | |
| LIF-IGF2R | |
| LIF-IL6ST | |
| LIF-LIFR | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NRG1-CD44 | |
| NRG1-EGFR | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PRL-PRLR | |
| TGFA-EGFR | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| THPO-EPOR | |
| THPO-MPL | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| TNFSF11-TNFRSF11A | |
| TNFSF11-TNFRSF11B | |
| TNFSF5-CD28 | |
| TNFSF5-CD80 | |
| TNFSF5-TNFRSF5 | |
| TNFSF5-TNFRSF6 | |
| TNFSF5-TNFRSF7 | |
| TNFSF5-TNFRSF8 | |
| VEGF-EGFR | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| ERalpha | |
| GR | |
| TR | |
| NR common targets | |
| NR common regulators |
| GO Biological Process | JAK-STAT cascade |
|---|---|
| immune response | |
| intracellular signaling cascade | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| electron transport | |
| T cell homeostasis | |
| cytokine and chemokine mediated signaling pathway | |
| development of secondary female sexual characteristics | |
| development of secondary male sexual characteristics | |
| lactation | |
| lipid storage | |
| luteinization | |
| mammary gland development | |
| natural killer cell differentiation | |
| negative regulation of apoptosis | |
| negative regulation of erythrocyte differentiation | |
| positive regulation of B cell differentiation | |
| positive regulation of activated T cell proliferation | |
| positive regulation of body size | |
| positive regulation of cell proliferation | |
| positive regulation of inflammatory response | |
| positive regulation of interleukin-2 biosynthesis | |
| positive regulation of mitotic cell cycle | |
| positive regulation of survival gene product | |
| positive regulation of transcription from RNA polymerase II promoter | |
| pregnancy | |
| regulation of cell adhesion | |
| regulation of epithelial cell differentiation | |
| regulation of steroid metabolism | |
| regulation of transcription, DNA-dependent | |
| signal transduction | |
| regulation of transcription from Pol II promoter |
| Group | Sh2 |
|---|---|
| Transcription factors |
| State | p |
|---|
| MGI ID | 103036 |
|---|---|
| 2444864 |
| Swiss-Prot Accession | P42229 |
|---|
| OMIM ID | 601511 |
|---|---|
| OMIM:601511 |
| Source | Curated |
|---|---|
| BIND | |
| ResNet |