| Name | USF1 |
|---|---|
| Description | upstream transcription factor 1 |
| Owner | Public |
| URN | urn:agi-llid:7391 |
| Connectivity | 63 |
| Notes | This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. |
| Hugo ID | 12593 |
| Microarray ID | 1387624_at |
|---|---|
| af026476_at | |
| A_42_P688442 | |
| 1426164_a_at | |
| 1448805_at | |
| 93656_g_at | |
| u41741_s_at | |
| A_51_P233474 | |
| A_51_P233478 | |
| A_51_P291227 | |
| 231768_at | |
| x55666_at | |
| A_23_P23646 | |
| A_14_P110659 | |
| OH4034 | |
| OR1684 | |
| RA1110 |
| Chromosome position | 1 93.3 cM |
|---|---|
| 13q24 | |
| 1q22-q23 |
| GO ID | 0006006 |
|---|---|
| 0003677 | |
| 0003704 | |
| 0005634 | |
| 0006355 | |
| 0006366 | |
| 0030528 | |
| 0003700 | |
| 0005667 | |
| 0006350 | |
| 0045449 |
| Alias | UEF |
|---|---|
| USF | |
| upstream stimulatory factor | |
| Upstream stimulatory factor 1 | |
| Major late transcription factor 1 | |
| transcription factor usf | |
| USF1_HUMAN | |
| FCHL1 | |
| hyperlipidemia, combined 1 | |
| HYPLIP1 | |
| hyperlipidemia, combined | |
| Major late transcription factor I | |
| Upstream stimulatory factor I | |
| hyperlipidemia I | |
| hyperlipidemia, combined I | |
| hyperlipidemia 1 | |
| MLTFI | |
| upstream transcription factor 1 | |
| upstream transcription factor I | |
| USF I | |
| USF1 | |
| FCHL I | |
| HYPLIP I |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 12200434 |
|---|---|
| 2249772 |
| LocusLink ID | 22278 |
|---|---|
| 7821 | |
| 7391 | |
| 83586 |
| FunctionalClass | DNA binding |
|---|---|
| specific RNA polymerase II transcription factor | |
| transcription regulator | |
| transcription factor |
| RGD ID | 620974 |
|---|
| Hugo Symbol | USF1 |
|---|
| Unigene ID | Rn.10845 |
|---|---|
| Hs.414880 | |
| Mm.8 |
| GO Cellular Component | transcription factor complex |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | THPO-EPOR |
|---|---|
| THPO-MPL | |
| TNFSF11-TNFRSF11A | |
| TNFSF11-TNFRSF11B | |
| TNFSF4-TNFRSF6 | |
| TNFSF5-TNFRSF6 | |
| TNFSF7-TNFRSF6 | |
| TNFSF8-TNFRSF6 | |
| TNFSF9-TNFRSF6 | |
| ERalpha | |
| TR |
| GO Biological Process | regulation of transcription |
|---|---|
| transcription | |
| regulation of transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| glucose metabolism | |
| transcription from Pol II promoter |
| Group | Transcription factors |
|---|
| State | upstream stimulatory factor 1 isoform 1 |
|---|---|
| upstream stimulatory factor 1 isoform 2 |
| State Description | Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1). |
|---|---|
| Transcript Variant: This variant (2), also known as USF1-BD, uses an alternate splice site in the coding region, compared to variant 1. The resulting isoform (2) uses a downstream start codon and codes for a shorter protein. |
| MGI ID | 99542 |
|---|
| Swiss-Prot Accession | P22415 |
|---|
| OMIM ID | 191523 |
|---|---|
| 602491 |
| Source | Curated |
|---|