| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:7067:out-urn:agi-protfc:malic%20enzyme::negative |
| Entities | malic enzyme |--- THRA |
| References | 5 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i32 p20108 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/32/20108 |
| MedLine Reference | 9242684:1086 |
| Sentence | Transfection analyses using a CAT reporter gene in NIH3T3 cells confirm that TRalpha1 can control the ME promoter, as a T 3 -dependent 7-fold stimulation of the reporter gene expression was observed. |
| CellLineName | cef |
|---|---|
| CellType | fibroblast |
| Tissue | egg |
| MedLine Reference | 1351057:6 |
| Sentence | Thus, the unliganded TR alpha is a transcriptional repressor of the malic enzyme gene; binding of T3 to the receptor abolishes this repression. |
| Organism | Mus musculus |
|---|---|
| CellLineName | NIH 3T3 |
| MedLine Reference | 9406846:3 |
| Sentence | Addition of 100 nM T4 to the culture medium in the presence of TRalpha increased the basal level of ME-TRE-TK-CAT expression by 4.5-fold. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v272 i38 p23606 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/38/23606 |
| MedLine Reference | 9295300:1344 |
| Sentence | Both TRalpha and the bound c-Fos/ATF-2 complex may interact with a bridging factor that regulates transcription of the malic enzyme gene. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | Endocrinology |
| Journal Reference | v138 i11 p4705 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/11/4705 |
| MedLine Reference | 9348197:1069 |
| Sentence | Results Top Abstract Introduction Materials and Methods Results Discussion References TRalpha2 inhibits T3/TRbeta1-dependent transcriptional activation of MBP but not ME native promoters. |