| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:7067:out-urn:agi-llid:7068::positive |
| Entities | THRB <+-- THRA |
| References | 7 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v142 i2 p544 (2001) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/2/544 |
| Organ | heart |
| MedLine Reference | 11159823:1046 |
| Sentence | Recently published reports indicate that mice with deletion of T3Ralpha1 ( i.e. only expressing the T3Rbeta gene) have bradycardia ( 19 , 20 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v138 i11 p4705 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/11/4705 |
| MedLine Reference | 9348197:1164 |
| Sentence | In fact, transfection of equal amounts of TRbeta1 and wild-type TRalpha2 expression plasmids resulted in inhibition of T3/TRbeta1 transactivation of MBP256-CAT by approximately 50%. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | GH3 |
| Tissue | thyroid |
| MedLine Reference | 10386183:4 |
| Sentence | Addition of lithium to thyroid hormone-deficient GH3 cells decreased TR alpha 1, alpha 2, and beta 2 expression without affecting TR beta 1 expression at 2 but not 5 days. |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12782404:4 |
| Sentence | In liver, regulation of TR beta1 and TR alpha2 subtype expression is inversely related to TH levels and the regulation of TR beta expression is, in part, controlled by TR alpha. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrinology |
| CellType | chondrocyte |
| Journal Reference | v141 i10 p3887 (2000) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/10/3887 |
| MedLine Reference | 11014246:1107 |
| Sentence | In these regions approximately 30% of chondrocytes expressed TRalpha1, 45% expressed TRalpha2, and 45A?A?A?50% expressed TRbeta1 (Figs. 1 and 2 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v143 i2 p343 (1997) |
| Tissue | thyroid |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/2/343 |
| MedLine Reference | 11796485:1043 |
| Sentence | By the same experimental approach, a thyroid hormone-induced up-regulation of TRbeta1 accompanied by a reduction of TRbeta2 and TRalpha mRNA was also observed ( 19 ). |
| Tissue | thyroid |
|---|---|
| MedLine Reference | 1782215:4 |
| Sentence | Transfected TR alpha 2 functions as a constitutive repressor of the transcriptional activators TR alpha 1 and TR beta 1 but also represses heterologous receptors, including the retinoic acid receptor and the estrogen receptor, which can activate TRE-controlled genes. |