| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:7067:out-urn:agi-llid:6256::positive |
| Entities | THRA --+> RXRA |
| References | 8 |
| Effect | positive |
| Connectivity | 2 |
| MedLine Reference | 11027684:1219 |
|---|---|
| Sentence | Inclusion of RXRalpha in the binding reactions with LXRalpha, LXReta, and TRalpha stimulated the formation of high affinity protein-DNA complexes containing LXRalpha/RXRalpha, LXReta/RXRalpha, and TRalpha/RXRalpha, respectively. |
| CellType | hepatocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i2 p974 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/2/974 |
| MedLine Reference | 8093812:5 |
|---|---|
| Sentence | In addition, v-erbA-RXR-alpha heterodimers specifically bind natural thyroid hormone-responsive elements (TREs) but not retinoic acid-responsive elements (RAREs). |
| MedLine Reference | 8297796:4 |
|---|---|
| Sentence | Electrophoretic mobility shift analysis experiments showed that thyroid hormone receptor alpha (TR alpha) and retinoid X receptor alpha (RXR alpha) formed a heterodimeric complex on the MM TRE that was specifically competed by classical TREs and not by other response elements. |
| Organism | Mus musculus |
| MedLine Reference | 8127707:9 |
|---|---|
| Sentence | In conclusion our data suggest that the TRE in the helix loop helix gene, myoD, is a target for the direct heterodimeric binding of TR alpha and RXR alpha/gamma. |
| Tissue | muscle |
| Organism | Mus musculus |
| MedLine Reference | 7925126:5 |
|---|---|
| Sentence | Second, the specific flanking and spacing sequences of DR4 influenced the contact sites and the binding of TR alpha monomer and homodimer, but not TR alpha/RXR alpha heterodimer. |
| Tissue | thyroid |
| MedLine Reference | 8559662:6 |
|---|---|
| Sentence | Electrophoretic mobility shift assays showed that the repeat element was able to form retarded complexes with TR alpha homodimers, as well as with TR alpha-RXR alpha heterodimers. |
| Organ | kidney |
| Organism | Mus musculus |
| MedLine Reference | 9295326:2 |
|---|---|
| Sentence | We characterized the interaction between TRalpha1 and RXRalpha via their ligand binding domains (LBDs) and the effect of ligands on the interaction using a yeast two-hybrid system. |
| MedLine Reference | 11278601:1175 |
|---|---|
| Sentence | The ability of T3Ralpha to repress reporter gene expression in transfected cells was analyzed in the presence of increasing amounts of an RXRalpha expression vector. |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i20 p16857 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/20/16857 |