| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:10562:out-urn:agi-llid:7068::positive |
| Entities | THRB <+-- GW112 |
| References | 6 |
| Effect | positive |
| Connectivity | 2 |
| MedLine Reference | 12965872:1049 |
|---|---|
| Sentence | GC-1 binds TRbeta with the same affinity as T3 but binds TRalpha1 with an affinity that is 10 times lower compared with T3. |
| Tissue | thyroid |
| Journal | Endocrin. Metabol |
| Journal Reference | v285 i5 pE1135 (2003) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/285/5/E1135 |
| Organism | Rattus norvegicus |
| MedLine Reference | 10965873:1047 |
|---|---|
| Sentence | It is not yet known whether the GC-1 bound TRbeta interacts with the same range of coactivators as the TR bound to T3 or, for that matter, whether GC-1 binding causes corepressor to dissociate from TR. |
| Organ | heart |
| Journal | Endocrinology |
| Journal Reference | v141 i9 p3055 (2000) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/9/3055 |
| MedLine Reference | 15100213:1221 |
|---|---|
| Sentence | Although these observations may be partially explained by the selective binding of GC-1 to TRbeta as well as preferential liver versus heart uptake ( 54 ), coregulator selectivity may also play a role. |
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i26 p27584 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/26/27584 |
| MedLine Reference | 11891331:8 |
|---|---|
| Sentence | In contrast, treatment with GC-1, which binds to TRbeta but not TRalpha1, partially corrects Purkinje cell differentiation but has no effect on granule cell migration. |
| CellLineName | Purkinje |
| Organism | Mus musculus |
| MedLine Reference | 15056670:1108 |
|---|---|
| Sentence | The dose-response curves for T3 activation of TRalpha and TRbeta on an upstream activation sequence-based reporter gene were virtually identical, whereas GC-1 activated TRbeta at lower concentrations than TRalpha ( Fig. 3, A and B ). |
| Organ | kidney |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i25 p26555 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/25/26555 |
| MedLine Reference | 14726446:5 |
|---|---|
| Sentence | TRalpha isoforms in TRH regulation in wild-type mice in vivo by using the TRbeta preferential agonist GC-1. |
| Organ | pituitar |
| Organism | Mus musculus |