| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-go:0004886:out-urn:agi-llid:7067::positive |
| Entities | THRA <+-- retinoid-X receptor |
| References | 14 |
| Effect | positive |
| Connectivity | 2 |
| MedLine Reference | 8910436:1144 |
|---|---|
| Sentence | Effect of DR4 spacer sequences on TRalpha2 heterodimerization with RXR. |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i45 p28199 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/45/28199 |
| Organism | Rattus norvegicus |
| MedLine Reference | 7903219:3 |
|---|---|
| Sentence | The RSV-T3RE is recognized and activated by either c-ErbA alpha homodimers or c-ErbA alpha/retinoid X receptor (RXR) heterodimers. |
| CellLineName | T3 |
| MedLine Reference | 9773977:9 |
|---|---|
| Sentence | Mutations within the DBD dimerization interface abolished heterodimerization of full-length TRv alpha2 with RXR but only marginally affected heterodimerization of full-length TR alpha1 with RXR. |
| MedLine Reference | 9879977:3 |
|---|---|
| Sentence | By applying a PCR-based screening assay we isolated DNA sequences to which p75(gag-v-erbA) binds as a heterodimer with RXR, and characterized these with regard to their nucleotide sequence and ability to associate with RXR/P75(gag-v-erbA) heterodimers in vitro and in vivo. |
| MedLine Reference | 12388540:1163 |
|---|---|
| Sentence | Unliganded T3Ralpha dimers (shown as homodimers here, but they can also be heterodimers with retinoid X receptor) bind to the MHC-T3RE (an example of a pHRE ). |
| CellLineName | T3 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i51 p49517 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/51/49517 |
| MedLine Reference | 9731697:1185 |
|---|---|
| Sentence | Both c-erbA/TR and v-erbA associate with RXR, an obligate heterodimeric partner of a number of NRs ( 4 , 5 , 47 ). |
| CellLineName | RED |
| Tissue | erythroid |
| Journal | Mol. Endocrin |
| Journal Reference | v12 i9 p1269 (1998) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/12/9/1269 |
| MedLine Reference | 9348197:1210 |
|---|---|
| Sentence | Cotransfection of increasing concentrations of RXR, in fact, was not able to relieve TRalpha2 inhibition of T3/TRbeta1 transactivation, further indicating that squelching by use of RXR for heterodimerization with functional TRs is not responsible for the DNA binding-independent component of TRalpha2 dominant negative activity (data not shown and Ref. 28 ). |
| Journal | Endocrinology |
| Journal Reference | v138 i11 p4705 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/11/4705 |
| Organism | Rattus norvegicus |
| MedLine Reference | 9731706:1122 |
|---|---|
| Sentence | Role of RXR in v-erbA Binding to the Consensus Sequences Since it is known that RXR may enhance v-erbA binding to DNA, we desired to address the binding of v-erbA-RXR heterodimers to these different mutant oligonucleotides. |
| Journal | Mol. Endocrin |
| Journal Reference | v12 i9 p1380 (1998) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/12/9/1380 |
| Organism | Mus musculus |
| MedLine Reference | 12054736:4 |
|---|---|
| Sentence | Furthermore, functional studies on transient transfections showed that v-erbA-RXR heterodimers do not mediate the dominant negative activity of v-erbA on an inverted repeat response element. |
| Organism | Mus musculus |
| MedLine Reference | 15293789:4 |
|---|---|
| Sentence | Our data also suggest that v-erbA homodimers interact preferentially with the corepressor NCoR over SMRT and that the interaction with corepressors is stronger with v-erbA homodimers over v-erbA-RXR heterodimers. |
| Tissue | thyroid |
| MedLine Reference | 15585599:4 |
|---|---|
| CellLineName | GH3 |
| Organism | Rattus norvegicus |
| MedLine Reference | 10409738:1126 |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v19 i8 p5486 (1999) |
| Journal Link | http://mcb.asm.org/cgi/content/full/19/8/5486 |
| MedLine Reference | 10454590:1170 |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v19 i9 p6448 (1999) |
| Journal Link | http://mcb.asm.org/cgi/content/full/19/9/6448 |
| MedLine Reference | 9605927:1153 |
|---|---|
| CellLineName | JEG |
| Journal | Mol. Endocrin |
| Journal Reference | v12 i5 p645 (1998) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/12/5/645 |
| Organism | Mus musculus |