| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-go:0004886:out-urn:agi-llid:7068::negative |
| Entities | THRB |--- retinoid-X receptor |
| References | 7 |
| Effect | negative |
| Connectivity | 2 |
| MedLine Reference | 7629175:3 |
|---|---|
| Sentence | Using a T3-responsive in vivo transcription system established by introducing TRs and RXRs into Xenopus oocytes, we demonstrated that TR-RXR heterodimers repressed TR beta gene promoter in the absence of T3 and activated the promoter in the presence of the hormone. |
| CellType | oocyte |
| MedLine Reference | 9348197:1210 |
|---|---|
| Sentence | Cotransfection of increasing concentrations of RXR, in fact, was not able to relieve TRalpha2 inhibition of T3/TRbeta1 transactivation, further indicating that squelching by use of RXR for heterodimerization with functional TRs is not responsible for the DNA binding-independent component of TRalpha2 dominant negative activity (data not shown and Ref. 28 ). |
| Journal | Endocrinology |
| Journal Reference | v138 i11 p4705 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/11/4705 |
| Organism | Rattus norvegicus |
| MedLine Reference | 12960053:6 |
|---|---|
| Sentence | EMSAs with subfragments from this region identify a 146-bp DNA fragment capable of binding a TRbeta1-retinoid X receptor heterodimer. |
| Tissue | thyroid |
| Organism | Rattus norvegicus |
| MedLine Reference | 9564869:1090 |
|---|---|
| Sentence | For example, the DR4 sequences that bind alpha2/RXR also bind TRbeta1 and TRalpha1 homodimers (with the exception of the Moloney leukemia virus TRE). |
| CellLineName | MOLONEY |
| Journal | Endocrinology |
| Journal Reference | v139 i5 p2535 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/5/2535 |
| MedLine Reference | 7639710:6 |
|---|---|
| Sentence | P3(I) contains an AGGTCA-like motif that can bind the TR beta-RXR heterodimer. |
| CellLineName | HepG 2 |
| MedLine Reference | 7737997:7 |
|---|---|
| Sentence | Consistent with this hypothesis, we observe that, in the absence of thyroid hormone, TR-beta or a heterodimer of TR-beta and retinoid-X-receptor undergoes direct protein-protein interactions with the transcription factor IIB-TATA binding protein complex, an early intermediate during PIC assembly. |
| Tissue | thyroid |
| MedLine Reference | 9804293:1 |
|---|---|
| Sentence | Since in vitro, TRbeta binds to DNA as homodimers or as heterodimers with retinoid X receptors (RXRs), we investigated whether the TRbeta-/- phenotype may reflect loss of RXR-TRbeta heterodimer or TRbeta homodimer function. |
| CellType | Brain Stem |
| Organism | Mus musculus |