| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:8648:out-urn:agi-llid:7068::unknown |
| Entities | NCOA1 ---> THRB |
| References | 4 |
| Effect | unknown |
| Connectivity | 2 |
| MedLine Reference | 14985366:1167 |
|---|---|
| Sentence | PCB did not inhibit SRC-1 binding to TRbeta1 in vitro . |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i18 p18195 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/18/18195 |
| MedLine Reference | 3535420827 |
|---|---|
| Sentence | SRC-1 interacts with THR-beta. This interaction was modelled on a demonstrated interaction between human SRC-1 and rat TR-beta |
| MedLine Reference | 12576486:3 |
|---|---|
| Sentence | We have shown that 1) TRbeta(-/-)SRC-1(-/-) mice demonstrate more severe TH resistance than either the SRC-1(-/-) or TRbeta(-/-) mice; the additive effect indicates that SRC-1 has an independent role in TH action over that of TRbeta; 2) SRC-1 facilitates TRbeta and TRalpha-mediated down-regulation of TSH, as TRalpha(0/0)SRC-1(-/-) mice demonstrate TH resistance rather than hypersensitivity as seen in TRalpha(0/0)mice; and 3) a compensatory increase in SRC-1 expression is associated with the TH hypersensitivity seen in TRalpha-deficient animals. |
| Tissue | thyroid |
| Organism | Mus musculus |
| MedLine Reference | 9751500:1057 |
|---|---|
| Sentence | An opposite pattern was observed for TRbeta-1 interaction with SRC-1 as ligand promoted formation of TRbeta-1/SRC-1/DNA complex (Fig. 1A , lanes 6 and 7). |
| Journal | Endocrinology |
| Journal Reference | v139 i10 p4197 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/10/4197 |