| Owner | Public |
|---|---|
| URN | urn:agi-Binding:inout-urn:agi-llid:7068:inout-urn:agi-llid:6256: |
| Entities | THRB ---- RXRA |
| References | 8 |
| Connectivity | 2 |
| MedLine Reference | 1324421:4 |
|---|---|
| Sentence | TR alpha and TR beta formed complexes with RXR alpha that strongly and selectively bound to natural thyroid hormone responsive elements, i.e. those from the rat alpha-myosin heavy chain gene and the rat malic enzyme gene. |
| Organism | Rattus norvegicus |
| Tissue | thyroid |
| MedLine Reference | 9171239:11 |
|---|---|
| Sentence | We further observed that a heterodimer of TRbeta and retinoid X receptor-alpha (RXR alpha), either in solution or bound to a DR+4 TRE, recruited SRC-1 in a T3-dependent manner. |
| Tissue | thyroid |
| MedLine Reference | 9893992:5 |
|---|---|
| Sentence | Experiments using DNA binding and competition assays showed that the proximal element B (-87/-72) binds strongly, in addition to HNF-4, ARP-1, EAR-2, and EAR-3, heterodimers of RXRalpha with RARalpha, and less efficiently, homodimers of RARalpha and heterodimers of RXRalpha with T3Rbeta or PPARalpha. |
| Organism | Rattus norvegicus |
| Organ | gastric |
| MedLine Reference | 12585964:5 |
|---|---|
| Sentence | Transactivation of the HCR-1/apoC-II promoter cluster by RXRalpha-FXRalpha heterodimers in the presence of CDCA was abolished by mutations either in the IR-1 HRE of the HCR-1 or in the thyroid HRE of the proximal apoC-II promoter, which binds RXRalpha-thyroid hormone receptor beta (T3Rbeta) heterodimers. |
| Tissue | thyroid |
| MedLine Reference | 12959642:6 |
|---|---|
| Sentence | These findings suggest a functional specificity of the two HREs of the apoA-II promoter for retinoids and thyroids, which is modulated by synergistic or antagonistic interactions between RXRalpha/T(3)Rbeta heterodimers and the ubiquitous transcription factor USF2a. |
| Tissue | thyroid |
| MedLine Reference | 8119145:8 |
|---|---|
| Sentence | Neither T3 nor 9-cis RA significantly affected TR beta 1/RXR alpha heterodimer formation. |
| MedLine Reference | 7479078:5 |
|---|---|
| Sentence | Similarly COUP-TF II homodimers and RXR alpha-TR beta heterodimers are favoured over COUP-TF II-TR beta heterodimers. |
| MedLine Reference | 9651383:2 |
|---|---|
| Sentence | It was found that element CIIC in addition to ARP-1 and EAR-2 binds RXRalpha/T3Rbeta heterodimers strongly, whereas element CIIB binds hepatic nuclear factor 4 (HNF-4) exclusively. |