| Name | scd |
|---|---|
| Description | stearoyl-CoA desaturase (delta-9-desaturase) |
| Owner | Public |
| URN | urn:agi-llid:6319 |
| Connectivity | 20 |
| Notes | Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in human breast cancer cells. No evidence that SCD sequence variation influences diabetes susceptibility or related traits. Of genes identified in the liver whose expression is modulated by leptin, stearoyl-CoA desaturase-1 ranks at the top of the list, according to this review. Results suggest that stearoyl-CoA desaturase levels are associated with the events of neoplastic cell transformation and programmed cell death. SCD activity index after rosiglitazone in PPARgamma mutation supports a pivotal role of PPARgamma function in SCD regulation. By globally regulating lipid metabolism, stearoyl-CoA desaturase activity modulates cell proliferation and survival and shows the role of endogenously synthesized monounsaturated fatty acids in sustaining the neoplastic phenotype of transformed cells. Increased palmitate and stearate desaturation by stearoyl-CoA desaturase was associated with the destabilization of ABCA1 by saturated fatty acids palmitate and stearate. Loss of SCD expression is a frequent event in prostate adenocarcinoma. Relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. Stearoyl-CoA desaturase influence on plasma triglycerides in hypertriglyceridemia. |
| Microarray ID | 1367668_a_at |
|---|---|
| 1415823_at | |
| 1415824_at | |
| 162077_f_at | |
| 95758_at | |
| 99697_f_at | |
| m26270_s_at | |
| A_51_P129464 | |
| 138407_f_at | |
| 1423366_at | |
| 1450956_at | |
| A_51_P446045 | |
| 200831_s_at | |
| 37513_at | |
| 200832_s_at | |
| 211708_s_at | |
| 223839_s_at | |
| 211162_x_at | |
| 31773_at | |
| rc_aa609164_at | |
| rc_t03441_f_at | |
| A_23_P63618 | |
| A_14_P104403 | |
| A_32_P163858 | |
| A_24_P626920 | |
| OH3276 | |
| OR1738A | |
| RA1268 | |
| AH1163 | |
| 1369037_at | |
| 1386889_at | |
| 1388253_at | |
| af036761_at | |
| af036761_g_at | |
| m15114_g_at | |
| rc_aa875269_at | |
| rc_ai011483_at | |
| rc_ai228830_s_at | |
| s75730_at | |
| u67995_s_at | |
| A_42_P813567 | |
| 1415822_at |
| Chromosome position | 19 C3 |
|---|---|
| 1q54 | |
| 10q23-q24 | |
| 19 43.0 cM |
| GO ID | 0008610 |
|---|---|
| 0004768 | |
| 0005506 | |
| 0005783 | |
| 0006633 | |
| 0016020 | |
| 0016021 | |
| 0016491 |
| Alias | 4930513N16Rik |
|---|---|
| Acyl-CoA desaturase | |
| asebia | |
| Scd2 | |
| Stearoyl-CoA desaturase | |
| stearoyl-Coenzyme A desaturase 1 | |
| stearoyl-Coenzyme A desaturase 2 | |
| stearoyl-coenzyme A desaturase 3 | |
| stearoyl-CoA 9-desaturase | |
| Delta(9)-desaturase | |
| stearoyl-coenzyme A desaturase III | |
| Scd1 | |
| stearoyl-CoA desaturase (delta-9-desaturase) | |
| Scd I | |
| fads5 | |
| predicted protein of hq0998 | |
| scd | |
| pro0998 | |
| stearoyl-CoA 9-desaturases | |
| Scd3 | |
| stearoyl-Coenzyme A desaturase II | |
| Fatty acid desaturase | |
| stearoyl-Coenzyme A desaturase I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 10716735 |
|---|---|
| 12466851 | |
| 10229681 |
| LocusLink ID | 83792 |
|---|---|
| 75065 | |
| 20250 | |
| 6319 | |
| 30049 |
| FunctionalClass | iron ion binding |
|---|---|
| oxidoreductase | |
| stearoyl-CoA 9-desaturase |
| GO Cellular Component | endoplasmic reticulum |
|---|---|
| integral to membrane | |
| membrane |
| Cell Localization | Plasma membrane |
|---|---|
| Endoplasmic reticulum | |
| Cytoplasm |
| Pathway | Full DuPont |
|---|---|
| DuPont 2 | |
| DuPont 4 | |
| Volcano 2 | |
| CLADiff | |
| LXR | |
| NR common targets | |
| DuPont 4 of 6 common targets | |
| DuPont 4 of 6 common regulators |
| GO Biological Process | fatty acid biosynthesis |
|---|---|
| lipid biosynthesis |
| Group | Metabolic enzymes |
|---|---|
| Full DuPont | |
| New Group | |
| CLA Diff | |
| duPont (4 of 6 FFA) |
| Source | Curated |
|---|