| Name | ANGPTL3 |
|---|---|
| Description | angiopoietin-like 3 |
| Owner | Public |
| URN | urn:agi-llid:27329 |
| Connectivity | 2 |
| Notes | Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. Angiopoietin-like 3 is predominantly expressed in the liver, however, its exact function is not known. The ANGPTL3 protein has the characteristic structure of angiopoietins: a signal peptide, an extended helical domain predicted to form dimeric or trimeric coiled-coils, a short linker peptide, and a globular fibrinogen homology domain (FHD). ANGPTL3 also does not contain the characteristic calcium-binding motif found in other angiopoietins. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. Angptl3 gene is a direct target of the liver X receptor (LXR). Data show that angiopoietin-like protein 3 (ANGPTL3) targets adipose cells and induces lipolysis. The cleavage of ANGPTL3 at two sites is important for the activation of ANGPTL3 in vivo. |
| Microarray ID | A_51_P481679 |
|---|---|
| 231684_at | |
| 54601_at | |
| 60264_at | |
| 70722_at | |
| 219803_at | |
| 243799_x_at | |
| rc_t73442_at | |
| A_23_P160262 | |
| A_14_P114270 | |
| OH7060 |
| Chromosome position | 5q33 |
|---|---|
| 1p31.1-p22.3 | |
| 4 48.0 cM |
| GO ID | 0005615 |
|---|---|
| 0004857 | |
| 0005178 | |
| 0005576 | |
| 0006641 | |
| 0007160 | |
| 0007229 | |
| 0016042 | |
| 0030335 | |
| 0045766 | |
| 0045834 |
| Alias | angiopoietin 5 |
|---|---|
| ANGPT5s | |
| angiopoietin V | |
| angiopoietin-like III | |
| Angiopoietin-related protein III | |
| ANGPTL3 | |
| hypolipidemia | |
| angiopoietin-like 3 | |
| Angiopoietin-related protein 3 | |
| ANGPT5 |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 11877390 |
|---|---|
| 12565906 | |
| 12975309 | |
| 10644446 | |
| 12466851 |
| LocusLink ID | 30924 |
|---|---|
| 27329 | |
| 10119 | |
| 502970 |
| FunctionalClass | enzyme inhibitor |
|---|---|
| integrin binding |
| GO Cellular Component | extracellular space |
|---|---|
| extracellular region |
| Cell Localization | Extracellular |
|---|
| Pathway | LXR |
|---|
| GO Biological Process | cell-matrix adhesion |
|---|---|
| integrin-mediated signaling pathway | |
| lipid catabolism | |
| positive regulation of angiogenesis | |
| positive regulation of cell migration | |
| positive regulation of lipid metabolism | |
| triacylglycerol metabolism |
| Group | Ligands |
|---|