| Name | TNF |
|---|---|
| Description | tumor necrosis factor (TNF superfamily, member 2) |
| Owner | Public |
| URN | urn:agi-llid:7124 |
| Connectivity | 405 |
| Notes | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
| Hugo ID | 11892 |
| Microarray ID | NM_012675 |
|---|---|
| 102630_s_at | |
| Msa.256.0_at | |
| NM_013693.1 | |
| NM_013693 | |
| NM_000594.2 | |
| I_3328355 | |
| I_1109711 | |
| 1387691_at | |
| e02468cds_s_at | |
| A_43_P11513 | |
| 102629_at | |
| 1419607_at | |
| tnfa_at | |
| x02611_s_at | |
| A_65_P16584 | |
| A_51_P385099 | |
| X01394 | |
| 207113_s_at | |
| 1852_at | |
| 259_s_at | |
| X02910_at | |
| A_32_P458667 | |
| A_23_P168071 | |
| A_23_P376488 | |
| A_14_P109737 | |
| A_14_P125975 | |
| A_14_P110091 | |
| A_24_P50759 | |
| R579 | |
| OR0747 | |
| 23 | |
| OH7652 | |
| RA0508 | |
| OR3746 |
| Chromosome position | 6p21.3 |
|---|---|
| 20p12 | |
| 17 19.06 cM |
| GO ID | 0007515 |
|---|---|
| 0019221 | |
| 0045672 | |
| 0050875 | |
| GO:0016020 | |
| GO:0016021 | |
| GO:0005887 | |
| GO:0005886 | |
| GO:0030141 | |
| GO:0045672 | |
| GO:0009615 | |
| GO:0006916 | |
| GO:0008220 | |
| GO:0007159 | |
| GO:0006355 | |
| GO:0007267 | |
| GO:0005625 | |
| GO:0006960 | |
| GO:0006889 | |
| GO:0005164 | |
| GO:0005125 | |
| GO:0007515 | |
| GO:0006927 | |
| GO:0008151 | |
| GO:0008284 | |
| GO:0006959 | |
| GO:0006952 | |
| GO:0006968 | |
| GO:0007275 | |
| GO:0006915 | |
| GO:0006955 | |
| GO:0008283 | |
| GO:0007165 | |
| GO:0006954 | |
| GO:0009887 | |
| GO:0042127 | |
| GO:0045670 | |
| GO:0045123 | |
| 0008625 | |
| 0005164 | |
| 0005615 | |
| 0005625 | |
| 0006355 | |
| 0006915 | |
| 0006916 | |
| 0006954 | |
| 0007159 | |
| 0007165 | |
| 0007267 | |
| 0008219 | |
| 0009615 | |
| 0016020 | |
| 0016021 | |
| 0009887 | |
| 0001932 | |
| 0005125 | |
| 0005886 | |
| 0005887 | |
| 0006006 | |
| 0006927 | |
| 0006952 | |
| 0006955 | |
| 0006959 | |
| 0006968 | |
| 0007275 | |
| 0008283 | |
| 0008284 | |
| 0030141 | |
| 0030316 | |
| 0042127 | |
| 0042742 | |
| 0043123 | |
| 0045123 | |
| 0045670 | |
| 0046325 | |
| 0048535 | |
| 0051023 | |
| 0004871 | |
| 0006917 |
| Alias | Tnf |
|---|---|
| superfamily, member 2 | |
| DIF | |
| tumor necrosis factor superfamily, member 2 | |
| Tumor necrosis factor alpha (cachetin) | |
| tumor necrosis factor superfamily member 2 | |
| tumor necrosis factor superfamily, member 2 | |
| TNF alpha | |
| tumor necrosis factor-alpha | |
| TNFalpha | |
| tumor necrosis factor alpha | |
| tumor necrosis factor alpha precursor | |
| Cachectin | |
| TNF superfamily, member 2 | |
| TNF, monocyte-derived | |
| TNFA | |
| TNF-alpha | |
| TNFSF2 | |
| tumor necrosis factor (TNF superfamily, member 2) | |
| tumor necrosis factor 2 | |
| tumor necrosis factor, alpha (cachectin) | |
| tumour necrosis factor alpha | |
| TNFA_HUMAN | |
| RATTNF | |
| TNF, macrophage-derived | |
| tumor necrosis factor, alpha (cachetin) | |
| TNF superfamily, member II | |
| tumor necrosis factor II | |
| tumor necrotizing factor alpha | |
| TNFSF2s | |
| tumor necrosis factor, alpha | |
| Tnfsf1a | |
| APC1 protein | |
| APC1 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Human |
| LocusLink ID | 24835 |
|---|---|
| 7124 | |
| 21926 | |
| 257551 | |
| 257601 |
| FunctionalClass | tumor necrosis factor receptor binding |
|---|---|
| cytokine | |
| signal transducer |
| RGD ID | 3876 |
|---|
| Hugo Symbol | TNF |
|---|
| Unigene ID | Rn.2275 |
|---|---|
| Mm.1293 | |
| Hs.241570 |
| KEGG pathway | Apoptosis |
|---|---|
| Cytokine-cytokine receptor interaction | |
| MAPK signaling pathway | |
| TGF-beta signaling pathway | |
| Toll-like receptor signaling pathway |
| Keyword | desmoplakin |
|---|---|
| death receptor | |
| tumor necrosis factor | |
| thrombin | |
| activated blood coagulation factor XIV | |
| LDL | |
| RAS small monomeric GTPase | |
| endotoxin | |
| dechlorinase | |
| receptor | |
| growth factor | |
| desmoplakins | |
| receptor activity | |
| endothelium-derived relaxation factor-forming enzyme | |
| RNA | |
| nuclei | |
| DNA | |
| 1.14.13.39 | |
| cytokine activity | |
| nucleus |
| GO Cellular Component | extracellular space |
|---|---|
| integral to membrane | |
| membrane | |
| soluble fraction | |
| integral to plasma membrane | |
| plasma membrane | |
| secretory granule |
| GO Molecular Function | tumor necrosis factor receptor binding |
|---|---|
| cytokine activity | |
| tumor necrosis factor receptor ligand activity |
| Cell Localization | Extracellular |
|---|
| Pathway | Death receptor signaling |
|---|---|
| Apoptosis | |
| Inhibition of Apoptosis | |
| NF-kB Signaling | |
| TNF-alpha signaling | |
| TNFR1 signaling | |
| TNF-alpha | |
| DR6 | |
| TNFRSF1A -> ZFP36 signalling pathway | |
| TNFRSF1A -> JUN signalling pathway | |
| TNFRSF1A -> FOS signalling pathway | |
| TNFRSF1A -> STAT1 signalling pathway | |
| TNFRSF1A -> STAT3 signalling pathway | |
| TNFRSF1A -> CREB1 signalling pathway | |
| TNFRSF1A -> ATF2 signalling pathway | |
| TNFRSF1A -> REL signalling pathway | |
| TNFRSF1A -> RELA signalling pathway | |
| TNFRSF1B -> JUN signalling pathway | |
| TNFRSF1B -> STAT1 signalling pathway | |
| TNFRSF1B -> LRRFIP1 signalling pathway | |
| TNFRSF1B -> CREB1 signalling pathway | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1A | |
| TNF-TNFRSF1B | |
| TNF-TNFRSF6 | |
| Full DuPont | |
| DuPont 2 | |
| DuPont 3 | |
| DuPont 4 | |
| Volcano 2 | |
| Ben Common regulators | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| LXR | |
| ERalpha | |
| NR common targets | |
| PPARalpha large | |
| DuPont 4 of 6 common targets | |
| DuPont 4 of 6 common regulators | |
| Donna's proteomics |
| GO Biological Process | anti-apoptosis |
|---|---|
| apoptosis | |
| cell death | |
| cell-cell signaling | |
| inflammatory response | |
| leukocyte adhesion | |
| regulation of transcription, DNA-dependent | |
| response to virus | |
| signal transduction | |
| cell proliferation | |
| cellular defense response | |
| cellular extravasation | |
| defense response | |
| defense response to bacteria | |
| development | |
| glucose metabolism | |
| humoral immune response | |
| immune response | |
| induction of apoptosis via death domain receptors | |
| lymph node development | |
| negative regulation of glucose import | |
| organogenesis | |
| osteoclast differentiation | |
| positive regulation of I-kappaB kinase/NF-kappaB cascade | |
| positive regulation of cell proliferation | |
| programmed cell death, transformed cells | |
| regulation of cell proliferation | |
| regulation of immunoglobulin secretion | |
| regulation of osteoclast differentiation | |
| regulation of protein amino acid phosphorylation | |
| cellular physiological process | |
| cytokine and chemokine mediated signaling pathway | |
| induction of apoptosis | |
| lymph gland development | |
| positive regulation of osteoclast differentiation | |
| leukocyte cell adhesion | |
| cell growth and/or maintenance | |
| necrosis | |
| regulation of calcium in ER | |
| killing transformed cells | |
| antimicrobial humoral response (sensu Invertebrata) | |
| response to viruses |
| Group | Ligands |
|---|---|
| Full DuPont | |
| New Group | |
| duPont (4 of 6 FFA) |
| MGI ID | 104798 |
|---|
| Swiss-Prot Accession | P01375 |
|---|
| OMIM ID | 191160 |
|---|---|
| 600807 | |
| 157300 | |
| OMIM:191160 |
| Source | Curated |
|---|---|
| BIND | |
| ResNet |