| Name | VEGF |
|---|---|
| Description | vascular endothelial growth factor |
| Owner | Public |
| URN | urn:agi-llid:7422 |
| Connectivity | 281 |
| Notes | Many polypeptide mitogens, such as basic fibroblast growth factor (FGFB; MIM 134920) and platelet-derived growth factors (MIM 173430, MIM 190040), are active on a wide range of different cell types. In contrast, vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. It is, however, structurally related to platelet-derived growth factor.[supplied by OMIM] |
| Hugo ID | 12680 |
| Microarray ID | R291 |
|---|---|
| 1370081_a_at | |
| OR0473 | |
| l20913_s_at | |
| m32167_at | |
| m32167_g_at | |
| A_43_P15572 | |
| A_51_P482552 | |
| A_52_P638895 | |
| A_65_P04405 | |
| A_52_P249424 | |
| A_65_P00680 | |
| M27281 | |
| 212171_x_at | |
| 36100_at | |
| 210512_s_at | |
| 210513_s_at | |
| MA864 | |
| 211527_x_at | |
| 1953_at | |
| 36101_s_at | |
| M27281_at | |
| M32977_s_at | |
| 73146_at | |
| A_23_P387668 | |
| A_14_P121725 | |
| A_14_P130755 | |
| A_14_P110329 | |
| A_24_P179400 | |
| A_23_P70398 | |
| A_23_P81805 | |
| A_14_P138589 | |
| A_24_P12401 | |
| M23 | |
| 210 | |
| OH7640 |
| Chromosome position | 17 24.2 cM |
|---|---|
| 9q12 | |
| 6p12 | |
| 19 A |
| GO ID | 0000074 |
|---|---|
| 0001525 | |
| 0001570 | |
| 0005172 | |
| 0005578 | |
| 0006950 | |
| 0007165 | |
| 0007399 | |
| 0008083 | |
| 0008201 | |
| 0008283 | |
| 0008284 | |
| 0016020 | |
| 0016477 | |
| 0030949 | |
| 0042803 | |
| 0043066 | |
| 0050840 | |
| 0050930 | |
| 0009967 | |
| 0005615 | |
| 0005737 | |
| 0006916 | |
| 0007275 | |
| 0007498 | |
| 0030154 |
| Alias | VPF |
|---|---|
| VEGF121 | |
| VEGF165 | |
| Vascular endothelial growth factor precursor | |
| vascular endothelial growth factor A | |
| GNB:37659 | |
| mgc70609 | |
| vascular endothelial growth factor variant | |
| Vascular permeability factor | |
| VEGF120 | |
| VEGF-A | |
| VEGF | |
| VEGFA |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| LocusLink ID | 114601 |
|---|---|
| 7422 | |
| 22339 | |
| 83785 |
| FunctionalClass | growth factor activity |
|---|---|
| vascular endothelial growth factor receptor ligand | |
| extracellular matrix binding | |
| growth factor | |
| heparin binding | |
| protein homodimerization | |
| vascular endothelial growth factor receptor binding |
| RGD ID | 619991 |
|---|
| Hugo Symbol | VEGF |
|---|
| Unigene ID | Hs.73793 |
|---|---|
| Rn.1923 | |
| Mm.282184 |
| KEGG pathway | Focal adhesion |
|---|
| GO Cellular Component | cytoplasm |
|---|---|
| extracellular space | |
| extracellular matrix (sensu Metazoa) | |
| membrane |
| Cell Localization | Extracellular |
|---|
| Pathway | KDR -> NFATC1 signalling pathway |
|---|---|
| KDR -> HIF1A signalling pathway | |
| KDR -> HSPCA signalling pathway | |
| KDR -> ATF1 signalling pathway | |
| KDR -> ETS1 signalling pathway | |
| KDR -> STAT1 signalling pathway | |
| KDR -> STAT6 signalling pathway | |
| KDR -> TAL1 signalling pathway | |
| KDR -> CREB1 signalling pathway | |
| KDR -> CTNNB1 signalling pathway | |
| KDR -> CTNND1 signalling pathway | |
| KDR -> EGR3 signalling pathway | |
| FLT1 -> NFATC1 signalling pathway | |
| FLT1 -> HIF1A signalling pathway | |
| FLT1 -> FOS signalling pathway | |
| FLT1 -> CREB1 signalling pathway | |
| VEGF-CD44 | |
| VEGF-EGFR | |
| VEGF-FLT1 | |
| VEGF-FLT4 | |
| VEGF-GPC1 | |
| VEGF-IL1R1 | |
| VEGF-KDR | |
| Full DuPont | |
| DuPont 2 | |
| DuPont 3 | |
| DuPont 4 | |
| Volcano 2 | |
| Ben Common regulators | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| LXR | |
| ERalpha | |
| NR common targets |
| GO Biological Process | anti-apoptosis |
|---|---|
| cell differentiation | |
| development | |
| mesoderm development | |
| angiogenesis | |
| cell migration | |
| cell proliferation | |
| induction of positive chemotaxis | |
| negative regulation of apoptosis | |
| neurogenesis | |
| positive regulation of cell proliferation | |
| positive regulation of vascular endothelial growth factor receptor signaling pathway | |
| regulation of progression through cell cycle | |
| response to stress | |
| signal transduction | |
| vasculogenesis | |
| positive regulation of signal transduction | |
| regulation of cell cycle |
| Group | Ligands |
|---|---|
| Full DuPont | |
| New Group |
| MGI ID | 103178 |
|---|
| Swiss-Prot Accession | P15692 |
|---|
| OMIM ID | 192240 |
|---|---|
| 125853 |
| Source | Curated |
|---|