| Entities | SREBF1 ---- NR1H3 |
|---|---|
| References | 49 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:6720:inout-urn:agi-llid:10062::positive |
| CellLineName | db |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2039 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2039 |
| MedLine Reference | 12923232:1016 |
| Sentence | The LXR target genes ABCA1, SREBP1c, FAS, and stearoyl-CoA desaturase 1 were upregulated by T0901317 treatment in both diabetic db/db and nondiabetic C57BLKS mice. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Diabetes |
| Journal Reference | v51 i7 p2037 (2002) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/51/7/2037 |
| MedLine Reference | 12086931:1209 |
| Sentence | Hepatic SREBP-1c mRNA expression requires endogenous LXR ligands ( 22 ). |
| Organism | Mus musculus |
| Tissue | blood |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v285 i4 pE685 (2003) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/285/4/E685 |
| MedLine Reference | 12959935:1147 |
| Sentence | For example, LXR is known to activate the expression of SREBP-1c, which has been reported to affect the expression of PEPCK (see above discussion). |
| Journal | Gastr. Liver Phys |
|---|---|
| Journal Reference | v284 i3 pG349 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G349 |
| MedLine Reference | 12576301:1110 |
| Sentence | LXRalpha stimulates SREBP-1c gene transcription to induce fatty acid and triglyceride synthesis. |
| Organ | liver |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v14 i22 p2819 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/22/2819 |
| MedLine Reference | 11090130:1041 |
| Sentence | In addition, feeding diets containing high cholesterol, rexinoids or LXR agonists results in an increase in SREBP-1c mRNA and protein expression in wild-type mice, but not in Lxralpha/eta -/- mice. |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Organ | liver |
| Journal | Endocrinology |
| Journal Reference | v143 i7 p2548 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/7/2548 |
| MedLine Reference | 12072387:1276 |
| Sentence | Additionally, LXR activation by F3MethylAA (but not PBFuranAA) was sufficient to elevate the steady-state mRNA levels of two other LXR target genes, ABCG1 and SREBP1 ( 22 , 25 , 40 , 41 , 42 ) (Fig. 7B ). |
| Organism | Rattus norvegicus |
| CellLineName | 293 |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i9 p2991 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/9/2991 |
| MedLine Reference | 11287605:1193 |
| Sentence | These data demonstrate that LXR and RXR and their ligands activate the SREBP-1c promoter activity in a synergistic fashion through the LXRE enhancer complex. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Tissue | fat |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1240 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1240 |
| MedLine Reference | 12730331:1263 |
| Sentence | PPAR has recently been reported to activate LXR gene expression ( 52 ), which could in turn activate SREBP-1c gene expression, leading to a speculation that these three factors could form an auto-loop activation in adipogenesis. |
| Organism | Rattus norvegicus |
| CellLineName | HepG 2 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2403 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2403 |
| MedLine Reference | 12441342:1094 |
| Sentence | The LXR agonist increased SREBP1 mRNA levels 4-fold as shown previously, and fenofibrate alone had no effect on basal levels of SREBP1 mRNA ( 6 ). |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i15 p13356 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13356 |
| MedLine Reference | 12551945:1258 |
| Sentence | This suggests that in chickens, the transcription of some lipogenic genes may be subject to direct LXR transactivation as well as indirectly through increased expression of SREBP-1c. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v279 i13 p12027 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/13/12027 |
| MedLine Reference | 14722127:1266 |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| Journal | PNAS |
| Journal Reference | v98 i4 p1477 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/4/1477 |
| MedLine Reference | 11171976:1017 |
| Organism | Rattus norvegicus |
| Journal | PNAS |
|---|---|
| Journal Reference | v98 i11 p6027 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/11/6027 |
| MedLine Reference | 11371634:1015 |
| Organism | Rattus norvegicus |
| Journal | PNAS |
|---|---|
| Journal Reference | v98 i24 p13607 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/24/13607 |
| MedLine Reference | 11717426:1225 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | PNAS |
| Journal Reference | v100 i9 p5419 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/9/5419 |
| MedLine Reference | 12697904:1121 |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| Journal | PNAS |
| Journal Reference | v102 i3 p791 (2005) |
| Journal Link | http://www.pnas.org/cgi/content/full/102/3/791 |
| MedLine Reference | 15637161:1015 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v40 i9 p1549 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/9/1549 |
| MedLine Reference | 10484602:1277 |
| Organism | Rattus norvegicus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i11 p1899 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/11/1899 |
| MedLine Reference | 12401889:1170 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 15509573:2 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i36 p34259 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/36/34259 |
| MedLine Reference | 11435428:1286 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i8 p3430 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/8/3430 |
| MedLine Reference | 15060163:1053 |
| Organism | Mus musculus |
| CellLineName | HEK 293 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i3 p1705 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/3/1705 |
| MedLine Reference | 11694526:1167 |
| Organism | Mus musculus |
| Tissue | blood |
|---|---|
| Organ | liver |
| Journal | Lipid Res |
| Journal Reference | v43 i1 p2 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| MedLine Reference | 11792716:1159 |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i9 p1400 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/9/1400 |
| MedLine Reference | 12235171:1151 |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v44 i11 p2109 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2109 |
| MedLine Reference | 12897189:1267 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 15388491:4 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| MedLine Reference | 15330762:7 |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v22 i16 p5989 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/16/5989 |
| MedLine Reference | 12138207:1378 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Tissue | mucosa |
| Organ | gastric |
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i16 p5780 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/16/5780 |
| MedLine Reference | 12897148:1270 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i16 p5896 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/16/5896 |
| MedLine Reference | 12897158:1270 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i6 p1019 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/1019 |
| MedLine Reference | 12663743:1181 |
| Organ | liver |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i6 p985 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| MedLine Reference | 12690094:1163 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | PNAS |
| Journal Reference | v100 i6 p3155 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/6/3155 |
| MedLine Reference | 12624180:1030 |
| Organism | Rattus norvegicus |
| Journal | ATVB |
|---|---|
| Journal Reference | v23 i7 p1169 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/7/1169 |
| MedLine Reference | 12615685:1113 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i2 p1324 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/2/1324 |
| MedLine Reference | 11684682:1057 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v278 i42 p40736 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/42/40736 |
| MedLine Reference | 12917410:1128 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| MedLine Reference | 14703507:1035 |
| Organism | Mus musculus |
| CellLineName | HepG 2 |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v14 i22 p2831 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/22/2831 |
| MedLine Reference | 11090131:1090 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v15 i10 p1206 (2001) |
| Journal Link | http://www.genesdev.org/cgi/content/full/15/10/1206 |
| MedLine Reference | 11358865:1171 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i11 p9520 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/11/9520 |
| MedLine Reference | 11782483:1243 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i13 p11019 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/13/11019 |
| MedLine Reference | 11790787:1041 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i21 p18793 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/21/18793 |
| MedLine Reference | 11901146:1036 |
| Organism | Rattus norvegicus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v44 i1 p136 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/1/136 |
| MedLine Reference | 12518032:1189 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i27 p28122 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/27/28122 |
| MedLine Reference | 15123650:1048 |
| Organism | Mus musculus |
| CellLineName | fgc4 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i27 p28113 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/27/28113 |
| MedLine Reference | 15123720:1237 |
| Organism | Rattus norvegicus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v42 i8 p1266 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/8/1266 |
| MedLine Reference | 11483628:1055 |
| Organ | liver |
|---|---|
| MedLine Reference | 12032166:8 |
| Organism | Mus musculus |
| Organ | gastric |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i20 p17576 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/20/17576 |
| MedLine Reference | 11278785:1259 |
| CellLineName | HEK 293 |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i21 p7756 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/21/7756 |
| MedLine Reference | 14560020:1205 |
| Organism | Mus musculus |