| Entities | PLTP ---- NR1H3 |
|---|---|
| References | 6 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5360:inout-urn:agi-llid:10062::unknown |
| Tissue | fat |
|---|---|
| Organ | gastric |
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i6 p2182 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/6/2182 |
| MedLine Reference | 12612088:1142 |
| Sentence | These findings demonstrate that LXR agonists induce both PLTP mRNA expression and enzymatic activity in vivo. |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i42 p39561 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/42/39561 |
| MedLine Reference | 12177004:1144 |
| Sentence | The combination of these two reagents resulted in additive activation of PLTP mRNA, suggesting that PLTP was regulated by the LXR/RXR heterodimer. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | ATVB |
| Journal Reference | v23 i5 p892 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/5/892 |
| MedLine Reference | 12649089:1140 |
| Sentence | Recent studies indicate that LXR activation leads to increased expression of PLTP. 36 However, PLTP activity was only measured by Cao et al, 36 who found a modest increase at very high doses of the LXR agonist T090131. 37,38 In addition, treatment with LXR agonist affects the expression of several genes involved in lipid metabolism and may result in a large increase in liver triglycerides. 38 Some of the reported effects on HDL metabolism also occur in PLTP-deficient mice, indicating that they are not dependent on PLTP activity. 36 Thus, treatment with LXR agonists will have other effects in addition to an increase of PLTP activity. |
| Organism | Mus musculus |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i6 p985 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| MedLine Reference | 12690094:1138 |
| Sentence | The LXR target genes CETP and PLTP and are both remodeling enzymes that transfer lipids between lipoproteins. |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Tissue | peritoneal |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i15 p13539 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13539 |
| MedLine Reference | 12531890:1028 |
| Sentence | Recently, it was shown ( 7 ) that LXR activation in macrophages also up-regulates phospholipid transfer protein (PLTP ) expression, but this up-regulation does not have any direct effect on cholesterol efflux from mouse peritoneal macrophages. |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i49 p49072 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/49/49072 |
| MedLine Reference | 12947111:1166 |
| Sentence | In CETP transgenic mice, ABCA1 and PLTP were also up-regulated by LXR agonist (2.3- and 2.5-fold, respectively) ( Fig. 6, A and B ). |
| Organism | Mus musculus |