| Entities | CYP7A1 ---- NR1H3 |
|---|---|
| References | 46 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:1581:inout-urn:agi-llid:10062::positive |
| Organ | liver |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v143 i7 p2548 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/7/2548 |
| MedLine Reference | 12072387:1305 |
| Sentence | Subsequent LXR-mediated hepatic cholesterol 7alpha-hydroxylase induction could allow for the elimination of excess cholesterol from the body. |
| Organism | Rattus norvegicus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i23 p20131 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/23/20131 |
| MedLine Reference | 11967256:1017 |
| Sentence | Electrophoretic mobility shift assays demonstrated the interaction of the liver X receptor alpha (LXRalpha): retinoid X receptor (RXR ) heterodimer, a transcription factor complex that is activated by oxysterols, with the murine Cyp7a1 gene promoter, whereas no binding to the human CYP7A1 gene promoter was detected. |
| Organism | Mus musculus |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i3 p386 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/3/386 |
| MedLine Reference | 12554795:1102 |
| Sentence | As expected, LXR bound efficiently as a heterodimer with RXR to the LXRE from the rat CYP7A1 promoter (Fig. 3 , A and B). |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v286 i5 pG730 (2004) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/286/5/G730 |
| MedLine Reference | 14684380:1147 |
| Sentence | As a result, the stimulatory effects of activated LXR-alpha upregulated CYP7A1 in rats fed Ch. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v14 i22 p2819 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/22/2819 |
| MedLine Reference | 11090130:1198 |
| Sentence | In the liver, LXR up-regulates the cholesterol 7alpha-hydroxylase (CYP7A1) gene to promote production and elimination of bile acids (Peet et al. 1998 ). |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i33 p29561 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/33/29561 |
| MedLine Reference | 12045201:1031 |
| Sentence | The transcriptional activation of CYP7A1 by LXR in rodents is counteracted by high bile acid levels that activate FXR . |
| Organ | liver |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v16 i3 p506 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/3/506 |
| MedLine Reference | 11875109:1197 |
| Sentence | However, there is no evidence that LXR is an activator of human CYP7a. |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i20 p15482 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/20/15482 |
| MedLine Reference | 10809780:1201 |
| Sentence | Finally, the constitutively reduced levels of normally an FGFR4-activated co-repressor of LXRalpha activity provide a basis for the elevated Cyp7a expression and consequent elevated bile acid synthesis observed in the FGFR4 (-/-) mice on standard chow. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i21 p18046 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/21/18046 |
| MedLine Reference | 11279093:1173 |
| Sentence | LRH-1 is a monomeric nuclear receptor that functions as a tissue-specific transcription factor and acts as a competence factor mediating the liver-specific regulation of the cholesterol 7 alpha-hydroxylase gene by LXRalpha ( 34-36 ). |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| Organ | vein |
| Journal | ATVB |
| Journal Reference | v23 i7 p1169 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/7/1169 |
| MedLine Reference | 12615685:1205 |
| Sentence | We have recently extended these findings by demonstrating that a synthetic LXR agonist induced CYP7A1 expression in rats in vivo and also in primary rat hepatocytes whereas the same molecule had no effect on CYP7A1 expression in primary human hepatocytes. 29 The species difference was not caused by a difference in affinity for rat versus human LXR receptors, as judged by transactivation assays and the fact that the synthetic agonist induced ABCA1 in the primary human hepatocytes. 29 In a similar vein, Chen et al 63 demonstrated that mice transgenic for human CYP7A1 on a mouse Cyp7A1 knockout background did not increase expression of the transgene in response to cholesterol feeding. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Cell |
| Journal Reference | v93 i5 p693 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/5/693 |
| MedLine Reference | 3051254690 |
| Organ | liver |
|---|---|
| Journal | DMD |
| Journal Reference | v32 i4 p367 (2004) |
| Journal Link | http://dmd.aspetjournals.org/cgi/content/full/32/4/367 |
| MedLine Reference | 15039287:1221 |
| Organism | Mus musculus |
| CellLineName | 293 |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v141 i11 p4180 (2000) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/11/4180 |
| MedLine Reference | 11089551:1097 |
| Organ | liver |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i3 p864 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/3/864 |
| MedLine Reference | 12529392:1020 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Nutrition |
| Journal Reference | v133 i1 p57 (2003) |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/1/57 |
| MedLine Reference | 12514267:1210 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | PNAS |
| Journal Reference | v97 i14 p7987 (2000) |
| Journal Link | http://www.pnas.org/cgi/content/full/97/14/7987 |
| MedLine Reference | 10884428:1243 |
| Organism | Mus musculus |
| CellLineName | HepG 2 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i27 p28122 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/27/28122 |
| MedLine Reference | 15123650:1286 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i7 p1169 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/7/1169 |
| MedLine Reference | 15102878:1422 |
| Tissue | adrenal |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v272 i6 p3137 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/6/3137 |
| MedLine Reference | 9013544:1117 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | J. Neurochem |
| Journal Reference | v88 i3 02183 (2004) |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2004.02183.x/full/ |
| MedLine Reference | 2565425941 |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i1 p2 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| MedLine Reference | 11792716:1147 |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i10 p1956 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/10/1956 |
| MedLine Reference | 12897188:1026 |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| MedLine Reference | 14703507:1035 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 11264982:3 |
| Organ | liver |
|---|---|
| MedLine Reference | 12117567:1 |
| Organism | Mus musculus |
| MedLine Reference | 14960721:1 |
|---|---|
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v20 i12 p4436 (2000) |
| Journal Link | http://mcb.asm.org/cgi/content/full/20/12/4436 |
| MedLine Reference | 10825207:1217 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v14 i11 p1739 (2000) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/14/11/1739 |
| MedLine Reference | 11075809:1131 |
| Organism | Mus musculus |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v16 i8 p1767 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/8/1767 |
| MedLine Reference | 12145333:1163 |
| Organism | Mus musculus |
| MedLine Reference | 10890879:1 |
|---|---|
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 11182136:1 |
| Organ | liver |
|---|---|
| MedLine Reference | 15694933:0 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i21 p16390 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/21/16390 |
| MedLine Reference | 10747970:1045 |
| CellLineName | HepG 2 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i11 p8988 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/11/8988 |
| MedLine Reference | 12519762:1267 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i6 p952 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/952 |
| MedLine Reference | 12032171:1139 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i8 p1538 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/8/1538 |
| MedLine Reference | 15145977:1022 |
| Organ | gastric |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i45 p41690 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/45/41690 |
| MedLine Reference | 11535594:1413 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i47 p43509 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43509 |
| MedLine Reference | 11546778:1034 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i1 p469 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/1/469 |
| MedLine Reference | 11682476:1213 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i45 p42588 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/45/42588 |
| MedLine Reference | 12202481:1291 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i38 p36091 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/38/36091 |
| MedLine Reference | 12847102:1025 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i48 p48283 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/48/48283 |
| MedLine Reference | 12970362:1280 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v284 i3 pG349 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G349 |
| MedLine Reference | 12576301:1094 |
| Organ | liver |
|---|---|
| Journal | ATVB |
| Journal Reference | v21 i6 p887 (2001) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/21/6/887 |
| MedLine Reference | 11397693:1288 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i27 p24767 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/27/24767 |
| MedLine Reference | 11331284:1030 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i15 p10918 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/15/10918 |
| MedLine Reference | 10753890:1193 |