| Entities | ABCA1 ---- NR1H3 |
|---|---|
| References | 90 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:19:inout-urn:agi-llid:10062::positive |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i8 p1499 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1499 |
| MedLine Reference | 12754274:1025 |
| Sentence | Furthermore, it has also been established that the liver X receptor (LXR), which belongs to the nuclear receptor superfamily, potently activates ABCA1 gene expression and cholesterol efflux ( 14 A?A?A? 18 ). |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i2 p263 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/2/263 |
| MedLine Reference | 14594998:1255 |
| Sentence | LXR and RXR also are known to upregulate ABCA1 expression and increase reverse cholesterol transport in macrophages. |
| Tissue | glia |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i39 p41197 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/39/41197 |
| MedLine Reference | 15269218:1121 |
| Sentence | However, the specific role of ABCA1 in promoting cholesterol efflux from glial cells is not yet clear because expression of other genes in addition to ABCA1 are also induced by LXR/RXR treatment ( 56 , 67 , 68 ). |
| Organism | Mus musculus |
| CellType | fibroblast |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| MedLine Reference | 14703507:1125 |
| Sentence | The LXR target gene ABCA1 is induced by LXR expression and agonist treatment as expected (D). |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Organ | liver |
| Journal | Lipid Res |
| Journal Reference | v45 i5 p972 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/5/972 |
| MedLine Reference | 14967823:1013 |
| Sentence | Here, we show that the saturated fatty acids palmitate and stearate also destabilize ABCA1 when Abca1 is induced by LXR/RXR ligands instead of cAMP. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 11788472:7 |
| Sentence | Furthermore, ligands of the retinoid X receptor and LXR activate ABCA1 in ECs at levels of both promoter activation and mRNA induction. |
| Organ | liver |
|---|---|
| Journal | PNAS |
| Journal Reference | v98 i5 p2610 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/5/2610 |
| MedLine Reference | 11226287:1115 |
| Sentence | LXR stimulates ABC-1- and -8-mediated reverse cholesterol transport from peripheral tissues to the liver ( 27 , 28 ). |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i52 p48702 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/52/48702 |
| MedLine Reference | 11641412:1037 |
| Sentence | Further studies demonstrated that such induction of ABCA1 may be mediated by the activation of the nuclear hormone receptor LXR ( 20 , 21 ). |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i21 p18793 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/21/18793 |
| MedLine Reference | 11901146:1217 |
| Sentence | In peripheral cells, particularly macrophages, LXR-mediated up-regulation of ABCA1, ABCG1, and apolipoprotein E promotes the efflux of free cholesterol and phospholipids to produce high density lipoprotein particles. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i50 p48508 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/50/48508 |
| MedLine Reference | 12384498:1029 |
| Sentence | Like many genes involved in cholesterol homeostasis, ABCA1 is regulated by the liver X receptors (LXR ) ( 6-8 ), nuclear receptors activated by oxysterols. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i7 p5692 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/7/5692 |
| MedLine Reference | 11741998:1038 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i49 p49072 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/49/49072 |
| MedLine Reference | 12947111:1213 |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v41 i3 p433 (2000) |
| Journal Link | http://www.jlr.org/cgi/content/full/41/3/433 |
| MedLine Reference | 10706591:1846 |
| Organ | liver |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v286 i5 pG730 (2004) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/286/5/G730 |
| MedLine Reference | 14684380:1140 |
| Organism | Rattus norvegicus |
| CellLineName | db |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2039 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2039 |
| MedLine Reference | 12923232:1016 |
| Organism | Mus musculus |
| Tissue | epithelia |
|---|---|
| Organ | lung |
| Journal | AJRCMB |
| Journal Reference | v31 i2 p227 (2004) |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/31/2/227 |
| MedLine Reference | 15039140:1132 |
| CellType | macrophage |
|---|---|
| Organ | liver |
| Journal | ATVB |
| Journal Reference | v22 i5 p717 (2002) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/22/5/717 |
| MedLine Reference | 12006382:1091 |
| Organ | artery |
|---|---|
| Journal | ATVB |
| Journal Reference | v23 i7 p1169 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/7/1169 |
| MedLine Reference | 12615685:1052 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | ATVB |
| Journal Reference | v24 i2 p230 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/2/230 |
| MedLine Reference | 14592855:1106 |
| CellLineName | RAW 264 |
|---|---|
| Journal | ATVB |
| Journal Reference | v24 i3 p519 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/3/519 |
| MedLine Reference | 14726413:1110 |
| Organism | Mus musculus |
| CellLineName | 293T |
|---|---|
| Journal | ATVB |
| Journal Reference | v24 i4 p703 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/4/703 |
| MedLine Reference | 14764426:1135 |
| CellType | macrophage |
|---|---|
| Journal | Circulation Res |
| Journal Reference | v93 i8 p717 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/93/8/717 |
| MedLine Reference | 14512442:1036 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| CellLineName | THP I |
| Journal | Endocrinology |
| Journal Reference | v143 i7 p2548 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/7/2548 |
| MedLine Reference | 12072387:1339 |
| Organism | Mus musculus |
| Tissue | epithelia |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i3 pG630 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/3/G630 |
| MedLine Reference | 12773300:1375 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i41 p37735 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/41/37735 |
| MedLine Reference | 11459853:1103 |
| CellLineName | HEK 293 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i6 p1019 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/1019 |
| MedLine Reference | 12663743:1142 |
| CellType | macrophage |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i16 p5780 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/16/5780 |
| MedLine Reference | 12897148:1031 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| MedLine Reference | 11604492:1 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i8 p1410 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/8/1410 |
| MedLine Reference | 15145986:1039 |
| Organism | Mus musculus |
| CellLineName | THP I |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i12 p10021 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/12/10021 |
| MedLine Reference | 11790770:1158 |
| CellType | enterocyte |
|---|---|
| Organ | gastric |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i13 p11019 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/13/11019 |
| MedLine Reference | 11790787:1202 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 12754201:4 |
| Organism | Mus musculus |
| CellType | neural |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i15 p13244 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13244 |
| MedLine Reference | 12547833:1394 |
| Organism | Rattus norvegicus |
| CellType | macrophage |
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| Journal | J. Biol. Chem |
| Journal Reference | v278 i24 p21344 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/24/21344 |
| MedLine Reference | 12672813:1036 |
| Organism | Mus musculus |
| CellType | fibroblast |
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| Organ | skin |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i3 p506 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/3/506 |
| MedLine Reference | 11875109:1104 |
| Organism | Mus musculus |
| CellType | neural |
|---|---|
| Tissue | glia |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i6 p1378 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/6/1378 |
| MedLine Reference | 12040022:1088 |
| Organism | Mus musculus |
| Organ | gastric |
|---|---|
| Journal | Mol. Endocrin |
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| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| MedLine Reference | 12690094:1085 |
| Organism | Mus musculus |
| CellType | macrophage |
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| Journal | Mol. Endocrin |
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| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1240 |
| MedLine Reference | 12730331:1243 |
| Organism | Mus musculus |
| CellType | myotube |
|---|---|
| Tissue | skeletal muscle |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i12 p2477 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/12/2477 |
| MedLine Reference | 14525954:1219 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| CellLineName | RAW264.7 |
| Journal | PNAS |
| Journal Reference | v97 i22 p12097 (2000) |
| Journal Link | http://www.pnas.org/cgi/content/full/97/22/12097 |
| MedLine Reference | 11035776:1099 |
| Organism | Mus musculus |
| CellLineName | NIH 3T3 |
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| Journal | PNAS |
| Journal Reference | v98 i2 p507 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/2/507 |
| MedLine Reference | 11149950:1115 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| CellLineName | THP I |
| Tissue | peritoneal |
| Journal | PNAS |
| Journal Reference | v98 i9 p5306 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/9/5306 |
| MedLine Reference | 11309497:1121 |
| Organ | aorta |
|---|---|
| Journal | PNAS |
| Journal Reference | v99 i11 p7604 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/11/7604 |
| MedLine Reference | 12032330:1165 |
| Organism | Mus musculus |
| Tissue | fat |
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| Organ | gastric |
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i6 p2182 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/6/2182 |
| MedLine Reference | 12612088:1138 |
| Organism | Mus musculus |
| CellLineName | RAW 264 |
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| Organ | kidney |
| Journal | Lipid Res |
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| Journal Link | http://www.jlr.org/cgi/content/full/42/9/1339 |
| MedLine Reference | 11518753:1097 |
| Organ | liver |
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| Journal Link | http://www.jbc.org/cgi/content/full/278/39/37368 |
| MedLine Reference | 12869555:1212 |
| CellType | macrophage |
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| Tissue | peritoneal |
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| Journal Link | http://www.jbc.org/cgi/content/full/278/44/42906 |
| MedLine Reference | 12917409:1130 |
| Organism | Mus musculus |
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| Journal | Lipid Res |
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| Organ | gastric |
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| Journal | Lipid Res |
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| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2049 |
| MedLine Reference | 12897186:1159 |
| Organism | Mus musculus |
| CellType | fibroblast |
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| MedLine Reference | 14656220:5 |
| CellType | sertoli |
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| CellLineName | TM3 |
| MedLine Reference | 15026428:3 |
| Organism | Mus musculus |
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| Organism | Mus musculus |
| Organ | liver |
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| Journal | Genes & Dev |
| Journal Reference | v14 i22 p2831 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/22/2831 |
| MedLine Reference | 11090131:1125 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
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| Journal Link | http://www.jbc.org/cgi/content/full/276/41/37731 |
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| Organ | small bowel |
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| Journal Link | http://www.jbc.org/cgi/content/full/278/38/36091 |
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| Organ | liver |
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| Organism | Mus musculus |
| Tissue | skeletal muscle |
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| Journal Link | http://www.pnas.org/cgi/content/full/100/9/5419 |
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| Organ | kidney |
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| Journal Link | http://www.genesdev.org/cgi/content/full/14/22/2819 |
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| Organ | brain |
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| Tissue | mesangia |
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