| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:10062:out-urn:agi-cas:57-88-5::unknown |
| Entities | cholesterol <--- NR1H3 |
| References | 77 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 10807731:1052 |
| Sentence | Coordinate regulation of different steps in reverse cholesterol transport by the LXR. |
| Journal | ATVB |
| Journal Reference | v20 i5 p1185 (2000) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/20/5/1185 |
| Tissue | muscle |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 12193599:1025 |
| Sentence | Furthermore we show that treatment of muscle cells in vitro with synthetic agonists of LXR increases the efflux of intracellular cholesterol to extracellular acceptors such as high density lipoprotein, thus identifying this tissue as a potential important regulator of reverse cholesterol transport and high density lipoprotein levels. |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i43 p40722 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/43/40722 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11604492:1253 |
| CellType | macrophage |
| Sentence | The role of LXR in this response appears to be to regulate several genes that have been directly implicated in the cholesterol efflux pathway including ABCA1 , ABCG1 , and apoE ( 5 , 11 , 22 , 28 , 29 ). |
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i22 p7558 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/22/7558 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12441342:1189 |
| CellType | macrophage |
| Sentence | Unlike the endogenous LXR antagonist geranylgeranyl pyrophosphate, fenofibrate does not negate the beneficial role LXR plays in reverse cholesterol transport in macrophages ( 36 , 37 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2403 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2403 |
| Organ | liver |
|---|---|
| MedLine Reference | 12482877:1014 |
| Sentence | MATERIALS AND METHODS RESULTS DISCUSSION REFERENCES Liver X receptor/retinoid X receptor (LXR/RXR) transcription factors have been found to induce a number of genes involved in the regulation of cellular cholesterol efflux, including the ATP-binding cassette transporter A1 (ABCA1 ), which mediates the active efflux of cellular cholesterol and phospholipids to extracellular acceptors, such as apolipoprotein A-I (apoA-I). |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i8 p5813 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/8/5813 |
| Organ | gastric |
|---|---|
| MedLine Reference | 12551945:1043 |
| Sentence | Although this suggested a role for ABCA1 in intestinal cholesterol absorption, the subsequent discovery of ABCG5 and ABCG8 , two other LXR-regulated ABC transporters involved in sterol trafficking ( 18-24 ), has offered another potential target for the LXR effect on cholesterol absorption. |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i15 p13356 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13356 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12601003:1040 |
| Sentence | Mice lacking LXRalpha accumulate large amounts of cholesterol in the liver when fed a high cholesterol diet ( 21 ), whereas wild type mice treated with an LXR agonist have decreased fractional absorption of dietary cholesterol ( 14 ) and increased biliary cholesterol excretion ( 25 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i18 p15565 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/18/15565 |
| MedLine Reference | 12736258:1160 |
|---|---|
| Sentence | Nonsterol LXR activators have been shown to increase reverse cholesterol transport ( 4 ), decrease local inflammatory markers ( 25 ), and prevent atherosclerosis in mice ( 26 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i29 p27138 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/29/27138 |
| Organ | brain |
|---|---|
| MedLine Reference | 3595090146 |
| CellType | neural |
| Sentence | In this regard, it is important to note that LXR agonists can increase cholesterol efflux even in the absence of exogenously added cholesterol acceptor. |
| Journal | J. Neurochem |
| Journal Reference | v88 i3 02183 (2004) |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2004.02183.x/full/ |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12897148:1251 |
| Sentence | The ability of LXR to regulate reverse cholesterol transport is due, at least in part, to regulation of ABCA1. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i16 p5780 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/16/5780 |
| MedLine Reference | 12040002:1101 |
|---|---|
| CellType | macrophage |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i6 p1135 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/6/1135 |
| Organism | Mus musculus |
|---|---|
| Organ | brain |
| MedLine Reference | 12040022:1092 |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i6 p1378 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/6/1378 |
| Tissue | fat |
|---|---|
| Organ | gastric |
| MedLine Reference | 12198243:1022 |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i9 p2065 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/9/2065 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | gastric |
| MedLine Reference | 12554795:1119 |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i3 p386 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/3/386 |
| Organ | liver |
|---|---|
| MedLine Reference | 12663743:1183 |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i6 p1019 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/1019 |
| Organism | Mus musculus |
|---|---|
| Organ | gastric |
| MedLine Reference | 12690094:1084 |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i6 p985 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11035776:1044 |
| CellType | macrophage |
| Journal | PNAS |
| Journal Reference | v97 i22 p12097 (2000) |
| Journal Link | http://www.pnas.org/cgi/content/full/97/22/12097 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11149950:1208 |
| CellType | macrophage |
| Journal | PNAS |
| Journal Reference | v98 i2 p507 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/2/507 |
| Organism | Mus musculus |
|---|---|
| Organ | intestine |
| MedLine Reference | 11226287:1117 |
| Journal | PNAS |
| Journal Reference | v98 i5 p2610 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/5/2610 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12032330:1190 |
| CellType | macrophage |
| Journal | PNAS |
| Journal Reference | v99 i11 p7604 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/11/7604 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12193651:1068 |
| CellType | macrophage |
| Journal | PNAS |
| Journal Reference | v99 i18 p11896 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/18/11896 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12368482:1017 |
| CellType | astrocyte |
| Journal | PNAS |
| Journal Reference | v99 i21 p13878 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/21/13878 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 15210959:1021 |
| CellType | macrophage |
| Journal | PNAS |
| Journal Reference | v101 i26 p9774 (2004) |
| Journal Link | http://www.pnas.org/cgi/content/full/101/26/9774 |
| MedLine Reference | 12531890:1027 |
|---|---|
| CellType | macrophage |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i15 p13539 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13539 |
| Organism | Mus musculus |
|---|---|
| Organ | gastric |
| MedLine Reference | 12847102:1011 |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i38 p36091 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/38/36091 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12138207:1056 |
| CellType | adipocyte |
| Journal | Mol. Cell. Biol |
| Journal Reference | v22 i16 p5989 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/16/5989 |
| MedLine Reference | 14592855:1103 |
|---|---|
| CellType | adipocyte |
| Journal | ATVB |
| Journal Reference | v24 i2 p230 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/2/230 |
| MedLine Reference | 2381877159 |
|---|---|
| Journal | Cell |
| Journal Reference | v93 i5 p693 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/5/693 |
| Organ | gastric |
|---|---|
| MedLine Reference | 2720753618 |
| Journal | Cell |
| Journal Reference | v103 i1 p1 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/1/1 |
| Organ | intestine |
|---|---|
| MedLine Reference | 3866600336 |
| Journal | Cell |
| Journal Reference | v104 i4 p503 (2001) |
| Journal Link | http://www.cell.com/cgi/content/full/104/4/503 |
| Tissue | marrow |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 14512442:1206 |
| CellType | macrophage |
| Journal | Circulation Res |
| Journal Reference | v93 i8 p717 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/93/8/717 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12072387:1280 |
| Journal | Endocrinology |
| Journal Reference | v143 i7 p2548 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/7/2548 |
| Organ | gastric |
|---|---|
| MedLine Reference | 11483617:1131 |
| Journal | Lipid Res |
| Journal Reference | v42 i8 p1173 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/8/1173 |
| MedLine Reference | 11518753:1050 |
|---|---|
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v42 i9 p1339 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/9/1339 |
| CellLineName | NIH 3T3 |
| Organ | artery |
|---|---|
| MedLine Reference | 11792716:1132 |
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v43 i1 p2 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| MedLine Reference | 11861659:1222 |
|---|---|
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v43 i2 p177 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/177 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11861672:1355 |
| Journal | Lipid Res |
| Journal Reference | v43 i2 p297 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/297 |
| Organ | gastric |
|---|---|
| MedLine Reference | 11907135:1287 |
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v43 i4 p533 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/4/533 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 11907139:1224 |
| Journal | Lipid Res |
| Journal Reference | v43 i4 p565 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/4/565 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12032171:1498 |
| Journal | Lipid Res |
| Journal Reference | v43 i6 p952 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/952 |
| Organ | liver |
|---|---|
| MedLine Reference | 12091489:1018 |
| Journal | Lipid Res |
| Journal Reference | v43 i7 p1054 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/7/1054 |
| CellLineName | CACO2 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12401893:1437 |
| Journal | Lipid Res |
| Journal Reference | v43 i11 p1939 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/11/1939 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12518032:1431 |
| Journal | Lipid Res |
| Journal Reference | v44 i1 p136 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/1/136 |
| MedLine Reference | 12700343:1768 |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i7 p1373 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/7/1373 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12754274:1447 |
| Journal | Lipid Res |
| Journal Reference | v44 i8 p1499 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1499 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12897189:1291 |
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2109 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2109 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12897193:1052 |
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2030 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2030 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 14703507:1034 |
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| Tissue | fecal |
|---|---|
| MedLine Reference | 14993242:1038 |
| Journal | Lipid Res |
| Journal Reference | v45 i5 p905 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/5/905 |
| Organ | gastric |
|---|---|
| MedLine Reference | 15121760:1192 |
| Journal | Lipid Res |
| Journal Reference | v45 i7 p1197 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/7/1197 |
| Organism | Mus musculus |
|---|---|
| Organ | gastric |
| MedLine Reference | 15145986:1027 |
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v45 i8 p1410 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/8/1410 |
| Organism | Mus musculus |
|---|---|
| Organ | brain |
| MedLine Reference | 15254070:1568 |
| Journal | Lipid Res |
| Journal Reference | v45 i8 p1375 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/8/1375 |
| Organ | liver |
|---|---|
| MedLine Reference | 11182136:1 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11546778:1 |
| CellType | macrophage |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 11755917:3 |
| Organism | Mus musculus |
|---|---|
| Organ | small bowel |
| MedLine Reference | 11985463:2 |
| CellType | macrophage |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12359143:4 |
| CellType | macrophage |
| Organ | gastric |
|---|---|
| MedLine Reference | 12559450:6 |
| CellType | hepatocyte |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12754201:2 |
| MedLine Reference | 12942148:8 |
|---|---|
| CellType | macrophage |
| Organ | liver |
|---|---|
| MedLine Reference | 14582448:1 |
| Organ | liver |
|---|---|
| MedLine Reference | 14748721:5 |
| CellType | macrophage |
| Organism | Mus musculus |
|---|---|
| Organ | artery |
| MedLine Reference | 12615685:1048 |
| Journal | ATVB |
| Journal Reference | v23 i7 p1169 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/7/1169 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12615696:1159 |
| Journal | ATVB |
| Journal Reference | v23 i3 p475 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/3/475 |
| CellLineName | THP I |
| Tissue | epithelia |
|---|---|
| MedLine Reference | 15034284:8 |
| MedLine Reference | 12631712:1265 |
|---|---|
| CellType | macrophage |
| Journal | Mol. Biol. Cell |
| Journal Reference | v14 i3 p903 (2003) |
| Journal Link | http://www.molbiolcell.org/cgi/content/full/14/3/903 |
| Organism | Mus musculus |
|---|---|
| Organ | gastric |
| MedLine Reference | 12612088:1046 |
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i6 p2182 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/6/2182 |
| Organ | liver |
|---|---|
| MedLine Reference | 12576301:1163 |
| CellType | macrophage |
| Journal | Gastr. Liver Phys |
| Journal Reference | v284 i3 pG349 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G349 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12773300:1039 |
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i3 pG630 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/3/G630 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12623780:1359 |
| CellType | adipocyte |
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH1 (2003) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H1 |
| Tissue | peritoneal |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 11559713:1141 |
| CellType | macrophage |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i47 p43564 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43564 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 11562371:1207 |
| CellType | hepatocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i46 p43018 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/46/43018 |
| CellLineName | KUPFFER |
| Organ | liver |
|---|---|
| MedLine Reference | 11741944:1031 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i7 p4713 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/7/4713 |
| MedLine Reference | 11790770:1266 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i12 p10021 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/12/10021 |
| Organism | Mus musculus |
|---|---|
| Organ | gastric |
| MedLine Reference | 11790787:1203 |
| CellType | enterocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i13 p11019 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/13/11019 |
| Tissue | fecal |
|---|---|
| Organism | Mus musculus |
| Organ | gastric |
| MedLine Reference | 12097330:1034 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i37 p34182 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/37/34182 |
| MedLine Reference | 11254888:3 |
|---|