| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-smol:oxysterol:out-urn:agi-llid:10062::positive |
| Entities | oxysterol --+> NR1H3 |
| References | 10 |
| Connectivity | 2 |
| Effect | positive |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i1 p2 (2002) |
| Tissue | blood |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| Organ | liver |
| MedLine Reference | 11792716:1187 |
| Sentence | Nonetheless, CYP7A1 appears to be a central target for multiple nuclear receptors; CYP7A1 expression is repressed by both bile acid-activated PXR and FXR, and induced by oxysterol-activated LXR. |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| CellType | adipocyte |
| Journal Reference | v24 i8 p3430 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/8/3430 |
| MedLine Reference | 15060163:1179 |
| Sentence | The expression of LXRalpha was also induced by T0901317 (Fig. 4 ), which is consistent with a recent report that oxysterol and synthetic LXR ligands induce the expression of LXRalpha mRNA ( 24 ). |
| Journal | J. Biol. Chem |
|---|---|
| CellType | Brain Stem |
| Journal Reference | v277 i42 p39243 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/42/39243 |
| MedLine Reference | 12161442:1253 |
| Sentence | To determine the effect of adrenic acid on oxysterol-regulated LXRalpha activity, a dose-response analysis was carried out. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v276 i36 p33969 (2001) |
| Tissue | peritoneal |
| Journal Link | http://www.jbc.org/cgi/content/full/276/36/33969 |
| MedLine Reference | 11423537:1219 |
| Sentence | This induction is most likely due to the oxysterol-dependent activation of LXRalpha or LXReta from the LXREs present within the first intron of the ABCA1 gene. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v40 i12 p2195 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/12/2195 |
| MedLine Reference | 10588945:1497 |
| Sentence | An oxysterol signaling pathway mediated by the nuclear receptor LXR . |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v39 i9 p1731 (1998) |
| Journal Link | http://www.jlr.org/cgi/content/full/39/9/1731 |
| MedLine Reference | 9741684:1280 |
| Sentence | An oxysterol signaling pathway mediated by the nuclear receptor LXR . |
| Journal | PNAS |
|---|---|
| Journal Reference | v99 i20 p12675 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/20/12675 |
| MedLine Reference | 12242342:1123 |
| Sentence | The initial experiments reported above indicate that addition of LY295427 restores INSIG-1 gene expression in the presence of 25HC, and also reverses oxysterol-mediated activation of LXR. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i47 p43564 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43564 |
| Organ | liver |
| MedLine Reference | 11559713:1036 |
| Sentence | The mechanism of this effect is increased gene transcription mediated by the oxysterol-activated transcription factor liver X receptor (LXR ) acting in a complex with retinoid X receptor (RXR ) at a site on the proximal promoter of the ABCA1 gene ( 24 ). |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i12 p10021 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/12/10021 |
| MedLine Reference | 11790770:1261 |
| Sentence | We have recently shown that 27-hydroxycholesterol is the major oxysterol that activates LXR in cholesterol-loaded human cells ( 23 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| CellType | macrophage |
| Journal Reference | v21 i22 p7558 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/22/7558 |
| MedLine Reference | 11604492:1260 |
| Sentence | Oxysterol and synthetic ligands of LXRs induce LXRalpha expression in human macrophage cell lines and primary human macrophages but not in murine cell lines or primary murine macrophages. |