| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:67254-79-9:out-urn:agi-llid:10062::negative |
| Entities | fatty acid ---| NR1H3 |
| References | 20 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i5 p772 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/5/772 |
| MedLine Reference | 11971949:1561 |
| Sentence | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i11 p1899 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/11/1899 |
| MedLine Reference | 12401889:1541 |
| Sentence | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i2 p296 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/2/296 |
| MedLine Reference | 12576511:1684 |
| Sentence | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v44 i6 p1199 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/6/1199 |
| MedLine Reference | 12639972:1435 |
| Sentence | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. |
| Journal | Gastr. Liver Phys |
|---|---|
| Journal Reference | v285 i5 pG796 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/5/G796 |
| Organ | liver |
| MedLine Reference | 14561586:1169 |
| Sentence | Recently, PUFA have been shown to activate the nuclear receptors PPAR and LXR as well as affect the processing of SREBP. |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 10809236:1 |
| Sentence | In this report we show that fatty acids are positive regulators of LXR alpha gene expression and we investigate the molecular mechanisms underlying this regulation. |
| Organ | breast |
|---|---|
| MedLine Reference | 15299184:8 |
| Sentence | LXRalpha gene expression is regulated by dietary fatty acids implicated in breast carcinogenesis and detection of LXRalpha expression in breast cancer cell lines and breast tumors in the present study indicates that LXRalpha may also be important in breast carcinogenesis. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i7 p5692 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/7/5692 |
| Organ | kidney |
| MedLine Reference | 11741998:1431 |
| Sentence | A recent study ( 28 ) showed that unsaturated fatty acids can act as competitive antagonists of LXR in cultured rat hepatoma and human embryonic kidney cell lines. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i12 p10691 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/12/10691 |
| Organ | liver |
| MedLine Reference | 11781314:1181 |
| Sentence | Furthermore, unsaturated fatty acids inhibit transcription of the SREBP-1c gene by antagonizing ligand-dependent activation of the LXR ( 38 ). |
| Journal | J. Biol. Chem |
|---|---|
| CellType | Brain Stem |
| Journal Reference | v277 i42 p39243 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/42/39243 |
| MedLine Reference | 12161442:1255 |
| Sentence | Neither fatty acid inhibited LXRalpha activity in HEK293-L cells, even up to 300 A?Aµ M . |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2403 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2403 |
| Organ | liver |
| MedLine Reference | 12441342:1214 |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i2 p297 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/297 |
| MedLine Reference | 11861672:1550 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i5 p742 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/5/742 |
| MedLine Reference | 11971945:1903 |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i8 p1441 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1441 |
| MedLine Reference | 12754280:1849 |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v276 i47 p43509 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43509 |
| MedLine Reference | 11546778:1205 |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i46 p43018 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/46/43018 |
| Organ | liver |
| MedLine Reference | 11562371:1198 |
| Journal | Lipid Res |
|---|---|
| CellType | macrophage |
| Journal Reference | v43 i1 p2 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| MedLine Reference | 11792716:1199 |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v45 i5 p972 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/5/972 |
| MedLine Reference | 14967823:1212 |
| Organ | liver |
|---|---|
| MedLine Reference | 12970175:5 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | PNAS |
| Journal Reference | v98 i11 p6027 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/11/6027 |
| MedLine Reference | 11371634:1190 |