| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:4318::negative |
| Entities | MMP9 |--- NR1H3 |
| References | 2 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v278 i12 p10443 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/12/10443 |
| MedLine Reference | 12531895:1018 |
| Sentence | We further show that the ability of LXR ligands to regulate MMP-9 expression is strictly receptor-dependent and is not observed in macrophages obtained from LXRalphabeta null mice. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i11 p9905 (2004) |
| Tissue | vascular |
| Journal Link | http://www.jbc.org/cgi/content/full/279/11/9905 |
| MedLine Reference | 14699103:1211 |
| Sentence | LXR activation also inhibits basal and cytokine-inducible expression of the matrix metalloproteinase (MMP-9), which is expressed in its active form in atherosclerotic lesions and is believed to play an important role in vascular remodeling and plaque instability ( 49 ). |