| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:64241::positive |
| Entities | ABCG8 <+-- NR1H3 |
| References | 9 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| CellType | hepatocyte |
| Journal Reference | v17 i6 p985 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| MedLine Reference | 12690094:1099 |
| Sentence | ABCG5 and ABCG8 expression is enhanced by LXR agonists in mice in a receptor-dependent manner ( 34 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2403 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2403 |
| Organ | liver |
| MedLine Reference | 12441342:1181 |
| Sentence | Likewise, LXR regulates the expression of ABCG5 and ABCG8 genes that promote secretion of sterols from the liver and decrease intestinal sterol retention, thereby facilitating coordinate regulation of sterol efflux and elimination. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i38 p36091 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/38/36091 |
| Organ | gastric |
| MedLine Reference | 12847102:1011 |
| Sentence | LXR activation induces the expression of ATP-binding cassette (ABC) transporters, such as ABCG5 and ABCG8, which inhibit intestinal absorption of cholesterol and phytosterols. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i21 p18793 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/21/18793 |
| Organ | gastric |
| MedLine Reference | 11901146:1231 |
| Sentence | Concurrent up-regulation of ABCG5 and ABCG8 promotes biliary sterol secretion, and in the intestine the LXR-mediated up-regulation of ABCA1, ABCG5, and ABCG8 prohibits the absorption of lumenal cholesterol thereby resulting in net cholesterol loss from the body. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v278 i48 p48275 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/48/48275 |
| MedLine Reference | 14504269:1240 |
| Sentence | G1, like G5 and G8 ( 15 ), is regulated by LXR ( 41 ), and expression of G1 is increased by cholesterol loading of macrophages ( 25 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i9 p1728 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/9/1728 |
| Organ | liver |
| MedLine Reference | 12777468:1095 |
| Sentence | Because ABCG5 and ABCG8 are regulated by LXRalpha, we examined whether these two transporters were affected by endotoxin. |
| Organism | Mus musculus |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i3 pG630 (2003) |
| Tissue | epithelia |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/3/G630 |
| MedLine Reference | 12773300:1383 |
| Sentence | First, LXRalpha/RXR activates the half-transporters ABCG5/ABCG8 ( 47 ), which have been implicated in biliary cholesterol secretion and intestinal cholesterol absorption ( 56 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i44 p45980 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/44/45980 |
| MedLine Reference | 15319426:1273 |
| Sentence | Three other ABC transporters, ABCG5, ABCG8, and ABCA1, are also known that are both involved in cellular sterol efflux and are activated by LXR. |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v45 i2 p253 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/2/253 |
| Organ | gastric |
| MedLine Reference | 14617739:1298 |
| Sentence | Likewise, LXR activation leads to upregulation of ABCG5/ABCG8 in mouse intestine ( 51 ). |