| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-go:0004009::positive |
| Entities | ATP-binding cassette <+-- NR1H3 |
| References | 5 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i38 p36091 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/38/36091 |
| Organ | gastric |
| MedLine Reference | 12847102:1011 |
| Sentence | LXR activation induces the expression of ATP-binding cassette (ABC) transporters, such as ABCG5 and ABCG8, which inhibit intestinal absorption of cholesterol and phytosterols. |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 15210833:1 |
| Sentence | Because LXR regulates the expression of ATP-binding cassette transporter (ABC) A1, which is involved in the high-density lipoprotein-related reverse cholesterol transport pathway, we examined the effects of an HMG-CoA reductase inhibitor pravastatin on ABCA1 expression in vitro and in vivo. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2403 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2403 |
| Organ | liver |
| MedLine Reference | 12441342:1186 |
| Sentence | In contrast to the ability of fenofibrate to antagonize LXR-induced expression of SREBP1 and FAS mRNA, fenofibrate did not reduce LXR-induced expression of the ABC transporters in liver. |
| Organism | Mus musculus |
|---|---|
| Journal | ATVB |
| Journal Reference | v23 i6 p972 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/6/972 |
| Organ | liver |
| MedLine Reference | 12615679:1142 |
| Sentence | Several conflicting reports have led to this controversy, including disparate results obtained in ABCA1-deficient mice, differences reported in the cell-specific location and subcellular distribution of ABCA1, and the finding that other ABC transporters are also regulated by LXR and RXR ligands. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i44 p45980 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/44/45980 |
| MedLine Reference | 15319426:1273 |
| Sentence | Three other ABC transporters, ABCG5, ABCG8, and ABCA1, are also known that are both involved in cellular sterol efflux and are activated by LXR. |