| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:355::positive |
| Entities | TNFRSF6 <+-- NR1H3 |
| References | 8 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i43 p40722 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/43/40722 |
| Organ | liver |
| MedLine Reference | 12193599:1094 |
| Sentence | Nevertheless, SCD-1 and FAS are significantly induced by LXR agonist treatment in the livers of these same animals (Fig. 2 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | HepG 2 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i13 p11019 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/13/11019 |
| MedLine Reference | 11790787:1023 |
| Sentence | Induction of FAS expression in HepG2 cells by LXR ligands is reduced, but not abolished, under conditions where SREBP processing is suppressed. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| Organ | liver |
| MedLine Reference | 14703507:1035 |
| Sentence | In the liver, LXR has been shown to regulate expression of CYP7A1, the rate-limiting enzyme in conversion of cholesterol to bile acids, and sterol-regulatory element binding protein 1c (SREBP-1c) and FAS, important lipogenic proteins ( 11 A? 14 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | db |
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2039 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2039 |
| MedLine Reference | 12923232:1016 |
| Sentence | The LXR target genes ABCA1, SREBP1c, FAS, and stearoyl-CoA desaturase 1 were upregulated by T0901317 treatment in both diabetic db/db and nondiabetic C57BLKS mice. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i37 p34182 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/37/34182 |
| MedLine Reference | 12097330:1038 |
| Sentence | Apart from indirect actions through SREBP-1c , LXR also directly influences transcription of Fas ( 22 ) and of genes encoding lipoprotein lipase ( 23 ), cholesterol ester transfer protein ( 24 ), and stearoyl-CoA desaturase-1 ( 25 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i16 p5896 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/16/5896 |
| Organ | liver |
| MedLine Reference | 12897158:1271 |
| Sentence | The Tontonoz laboratory observed, by transfecting FAS promoter-reporter constructs into cultured cells, that LXR also activates the FAS promoter by binding to an LXRE located at position -660 ( 17 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2403 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2403 |
| Organ | liver |
| MedLine Reference | 12441342:1186 |
| Sentence | In contrast to the ability of fenofibrate to antagonize LXR-induced expression of SREBP1 and FAS mRNA, fenofibrate did not reduce LXR-induced expression of the ABC transporters in liver. |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| CellType | adipocyte |
| Journal Reference | v24 i8 p3430 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/8/3430 |
| MedLine Reference | 15060163:1053 |
| Sentence | LXR activation with T0901317 preferentially increased the expression of lipogenic genes such as ADD1/SREBP1c and FAS and enhanced the expression of adipocyte-specific genes such as the PPARgamma and aP2 genes in vivo and in vitro. |