| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:6319::positive |
| Entities | scd <+-- NR1H3 |
| References | 9 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2039 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2039 |
| Organ | liver |
| MedLine Reference | 12923232:1150 |
| Sentence | The known LXR target genes ABCA1, SREBP1c, FAS, SCD1, LPL, and apoC-II were significantly upregulated in both strains by drug treatment. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v40 i9 p1549 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/9/1549 |
| Organ | liver |
| MedLine Reference | 10484602:1248 |
| Sentence | Mice lacking LXR receptor expressed low levels of SCD mRNA in the presence or absence of cholesterol feeding while the wild-type animals fed 2% cholesterol had their SCD mRNA levels up-regulated 4-fold ( 72 ). |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12754201:4 |
| Sentence | LXR activation resulted in increased levels of the ATP-binding cassette transporter A1 (ABCA1) and stearoyl CoA desaturase, and expression of these genes individually decreased formation of Abeta. |
| Organism | Mus musculus |
|---|---|
| CellLineName | C2C12 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i43 p40722 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/43/40722 |
| MedLine Reference | 12193599:1122 |
| Sentence | LXR target genes that contribute to lipogenesis such as SREBP1c , FAS , and SCD-1 were also induced by LXR agonist in C2C12 cells (Fig. 2 , D-F ). |
| Journal | J. Biol. Chem |
|---|---|
| CellType | macrophage |
| Journal Reference | v278 i8 p5813 (2003) |
| Tissue | peritoneal |
| Journal Link | http://www.jbc.org/cgi/content/full/278/8/5813 |
| MedLine Reference | 12482877:1115 |
| Sentence | RESULTS TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION REFERENCES Stearoyl-CoA Desaturase Is Induced by LXR/RXR in Macrophages-- In an attempt to identify genes that modulate the cholesterol efflux pathway, we carried out selective subtractive hybridization on mouse peritoneal macrophages treated with or without LXR/RXR activators, 22( R )-OH cholesterol (5 A?Aµ M ) and 9- cis -retinoic acid (10 A?Aµ M ). |
| Journal | Lipid Res |
|---|---|
| CellType | macrophage |
| Journal Reference | v44 i6 p1251 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/6/1251 |
| MedLine Reference | 12700344:1534 |
| Sentence | Oram LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1 J. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v44 i8 p1470 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1470 |
| MedLine Reference | 12730295:1840 |
| Sentence | Oram LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1 J. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v277 i21 p18793 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/21/18793 |
| Organ | liver |
| MedLine Reference | 11901146:1036 |
| Sentence | LXR activation also promotes the formation of cholesterol esters by increasing expression of SREBP-1c and stearoyl-CoA desaturase, resulting in increased production of oleic acid, the preferred substrate for cholesterol esterification ( 7 , 17 , 18 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v45 i5 p972 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/5/972 |
| MedLine Reference | 14967823:1040 |
| Sentence | Here, we present evidence that LXR/RXR ligands activate macrophage SCD to generate ABCA1-destabilizing monounsaturated fatty acids from their saturated precursors. |