| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:9619::positive |
| Entities | ABCG1 <+-- NR1H3 |
| References | 16 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| CellType | neural |
| Journal Reference | v16 i6 p1378 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/6/1378 |
| MedLine Reference | 12040022:1052 |
| Sentence | The LXR target genes ABCA1, ABCG1, and SREBP-1 were detected in each of the tissues/cultures examined (Table 1 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | DN |
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i10 p3583 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/10/3583 |
| Organ | liver |
| MedLine Reference | 12724417:1203 |
| Sentence | For instance, the LXR target genes ABCA1 , ABCG1 , and ABCG8 were less sensitive to the expression of DN2 in DN2-TG mice fed high-cholesterol diets. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v275 i19 p14700 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/19/14700 |
| MedLine Reference | 10799558:1173 |
| Sentence | Macrophages from wild-type or single LXR knockout mice expressed increased levels of ABC8 mRNA when treated with 22( R )-hydroxycholesterol. |
| Journal | J. Biol. Chem |
|---|---|
| CellType | macrophage |
| Journal Reference | v276 i42 p39438 (2001) |
| Tissue | peritoneal |
| Journal Link | http://www.jbc.org/cgi/content/full/276/42/39438 |
| MedLine Reference | 11500512:1049 |
| Sentence | Previous studies have led to the proposal that the nuclear receptor LXR is required for the induction of ABCG1 mRNA levels in lipid-loaded macrophages; this proposal is based on the observations that induction of ABCG1 mRNA levels (i) is enhanced when cells are incubated with LXR ligands, (ii) is stimulated when cells overexpress LXR , (iii) is attenuated when cells overexpress dominant negative forms of LXRalpha or LXReta, and (iv) is attenuated in peritoneal macrophages derived from LXRalpha -/- , LXReta -/- double knockout mice ( 4 , 5 ). |
| CellLineName | RAW246.7 |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v42 i10 p1513 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/10/1513 |
| MedLine Reference | 11590207:1071 |
| Sentence | The second important question involves the transcriptional regulation of the ABCG1 gene by LXR/RXR. |
| Organism | Mus musculus |
|---|---|
| CellType | macrophage |
| MedLine Reference | 11149950:7 |
| Sentence | Together with our previous work, these findings support a central role for LXR signaling pathways in the control of macrophage cholesterol efflux through the coordinate regulation of apoE, ABCA1, and ABCG1 expression. |
| CellLineName | CACO2 |
|---|---|
| Organ | gastric |
| MedLine Reference | 12091489:10 |
| Sentence | Thus, in CaCo-2 cells, LXR/RXR activation increases gene expression of ABCA1 and ABCG1 and the basolateral efflux of cholesterol, suggesting that ABCA1 plays an important role in intestinal HDL production and cholesterol absorption. |
| CellLineName | CACO2 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v16 i9 p2065 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/9/2065 |
| MedLine Reference | 12198243:1037 |
| Sentence | In Caco-2 cells, the LXR-dependent induction of ABCG1 mRNA expression is repressed after induction of SHP by chenodeoxycholic acid. |
| Journal | J. Biol. Chem |
|---|---|
| CellType | macrophage |
| Journal Reference | v278 i15 p13539 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13539 |
| MedLine Reference | 12531890:1027 |
| Sentence | Activation of LXR in macrophages increases not only ATP-binding cassette transporter A1 but also the expression of genes encoding ABCG1 and apoE ( 5 , 6 ), which may be also involved in efflux of cholesterol toward HDL. |
| CellLineName | THP I |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i48 p37324 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/48/37324 |
| MedLine Reference | 10973959:1206 |
| Sentence | It was previously reported that some of the effects of Ox-LDL could be attributed to PPARgamma ligands ( 57 , 31 , 32 ), and more recently, the cholesterol transporters ABC1 and ABC8 have been shown to be up-regulated by both LXR and RXR ligands ( 59-61 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | RAW264.7 |
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v276 i47 p43509 (2001) |
| Tissue | peritoneal |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43509 |
| MedLine Reference | 11546778:1119 |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v44 i9 p1728 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/9/1728 |
| MedLine Reference | 12777468:1167 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v277 i21 p18793 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/21/18793 |
| MedLine Reference | 11901146:1217 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrinology |
| CellType | macrophage |
| Journal Reference | v143 i7 p2548 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/7/2548 |
| Organ | liver |
| MedLine Reference | 12072387:1276 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i41 p37731 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/41/37731 |
| MedLine Reference | 11459852:1120 |
| CellLineName | THP I |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i52 p48702 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/52/48702 |
| MedLine Reference | 11641412:1088 |