| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:348::positive |
| Entities | APOE <+-- NR1H3 |
| References | 25 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i3 pG630 (2003) |
| Tissue | epithelia |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/3/G630 |
| MedLine Reference | 12773300:1378 |
| Sentence | Although we did not demonstrate apoE secretion into the BL membrane following LXRalpha/RXR treatment, nevertheless the upregulation of synthesis of apoE by LXRalpha/RXR may be another means to facilitate cholesterol efflux from the BL membrane, as discussed above. |
| Organism | Mus musculus |
|---|---|
| CellType | macrophage |
| MedLine Reference | 11604492:1 |
| Sentence | Macrophage lipid loading leads to ligand activation of LXRs and to induction of a pathway for cholesterol efflux involving the LXR target genes ABCA1 and apoE. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v277 i35 p31900 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/35/31900 |
| MedLine Reference | 12032151:1024 |
| Sentence | Taken together, these studies demonstrate that activated LXR induces the expression of the apoE/C-I/C-IV/C-II gene cluster in both human and murine macrophages. |
| Journal | J. Neurochem |
|---|---|
| Journal Reference | v86 i6 01950 (2003) |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2003.01950.x/full/ |
| MedLine Reference | 2226288753 |
| Sentence | This was expected, since although the endogenous apoE gene maybe up-regulated by LXR ( Repa and Mangelsdorf 2002 ), the expression of apoE in the adenoviruses is under the control of the CMV promoter, which is not regulated by LXR. |
| Journal | J. Neurochem |
|---|---|
| Journal Reference | v88 i3 02183 (2004) |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2004.02183.x/full/ |
| MedLine Reference | 2206138733 |
| Sentence | To examine whether LXR agonists induce apoE expression in vivo , we treated C57BL6 mice with T0901317 at doses of 1, 10 and 50 mg/kg (orally) for 7 days. |
| Journal | J. Neurochem |
|---|---|
| CellType | astrocyte |
| Journal Reference | v88 i3 02183 (2004) |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2004.02183.x/full/ |
| Organ | brain |
| MedLine Reference | 3108481625 |
| Sentence | The regulation of apoE expression in a human astrocytoma cell line by LXR/RXR is fairly robust, and is also observed in mouse primary astrocytes and in specific brain regions of mice treated with the selective LXR agonist T0901317. |
| CellLineName | ccf-sttg1 |
|---|---|
| Journal | J. Neurochem |
| CellType | astrocyte |
| Journal Reference | v88 i3 02183 (2004) |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2004.02183.x/full/ |
| Organ | brain |
| MedLine Reference | 3615450106 |
| Sentence | However, the regulation of apoE expression in mouse astrocytes and brain by LXR/RXR agonists is quantitatively rather modest compared with CCF-STTG1 cells. |
| Journal | J. Neurochem |
|---|---|
| CellType | macrophage |
| Journal Reference | v88 i3 02183 (2004) |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2004.02183.x/full/ |
| MedLine Reference | 3109857790 |
| Sentence | The apoE gene was previously reported to be regulated by LXR in both human and murine macrophages, which was attributed to a pair of LXR responsive elements (LXRE) identified at the 3' end of the human apoE gene in a region called the multi-enhancer (ME) region that has been shown to be essential for apoE expression in macrophages and adipocytes ( Shih et al . 2000 ; Laffitte et al . 2001 ). |
| Organism | Mus musculus |
|---|---|
| CellType | macrophage |
| Tissue | fat |
| MedLine Reference | 11149950:4 |
| Sentence | We show that LXR/RXR heterodimers regulate apoE transcription directly, through interaction with a conserved LXR response element present in both ME.1 and ME.2. |
| Organism | Mus musculus |
|---|---|
| Tissue | cortex |
| Organ | hippocampal |
| MedLine Reference | 14720212:4 |
| Sentence | Moreover, treatment of mice with a specific synthetic LXR agonist T0901317 resulted in up-regulation of apoE mRNA and protein in both hippocampus and cerebral cortex, indicating that apoE expression in brain can be up-regulated by LXR agonists in vivo. |
| CellType | fibroblast |
|---|---|
| MedLine Reference | 14656220:5 |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| CellType | macrophage |
| Journal Reference | v22 i8 p2607 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/8/2607 |
| MedLine Reference | 11909955:1298 |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v22 i16 p5989 (2002) |
| Tissue | fat |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/16/5989 |
| MedLine Reference | 12138207:1374 |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| CellType | macrophage |
| Journal Reference | v17 i6 p985 (2003) |
| Tissue | fat |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| Organ | liver |
| MedLine Reference | 12690094:1113 |
| Journal | J. Neurosci |
|---|---|
| CellType | astrocyte |
| Journal Reference | v21 i22 p8956 (2001) |
| Journal Link | http://www.jneurosci.org/cgi/content/full/21/22/8956 |
| MedLine Reference | 11698606:1032 |
| Organism | Mus musculus |
|---|---|
| Journal | PNAS |
| Journal Reference | v99 i18 p11896 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/18/11896 |
| Organ | liver |
| MedLine Reference | 12193651:1036 |
| Journal | J. Biol. Chem |
|---|---|
| CellType | macrophage |
| Journal Reference | v278 i15 p13539 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13539 |
| MedLine Reference | 12531890:1027 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | astrocyte |
| Journal Reference | v278 i15 p13244 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/15/13244 |
| MedLine Reference | 12547833:1402 |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v279 i11 p10643 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/11/10643 |
| MedLine Reference | 14699114:1047 |
| CellLineName | HepG 2 |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i2 p263 (2004) |
| Tissue | thyroid |
| Journal Link | http://www.jlr.org/cgi/content/full/45/2/263 |
| MedLine Reference | 14594998:1074 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v277 i21 p18793 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/21/18793 |
| MedLine Reference | 11901146:1217 |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i6 p1019 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/1019 |
| MedLine Reference | 12663743:1034 |
| Journal | Gastr. Liver Phys |
|---|---|
| CellType | macrophage |
| Journal Reference | v284 i3 pG349 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G349 |
| MedLine Reference | 12576301:1161 |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | neural |
| Journal Reference | v279 i39 p41197 (2004) |
| Tissue | glia |
| Journal Link | http://www.jbc.org/cgi/content/full/279/39/41197 |
| Organ | brain |
| MedLine Reference | 15269218:1120 |
| Organism | Mus musculus |
|---|---|
| CellType | macrophage |
| MedLine Reference | 14560020:5 |