| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:64240::positive |
| Entities | ABCG5 <+-- NR1H3 |
| References | 12 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | enterocyte |
| Journal Reference | v277 i21 p18793 (2002) |
| Tissue | villus |
| Journal Link | http://www.jbc.org/cgi/content/full/277/21/18793 |
| MedLine Reference | 11901146:1164 |
| Sentence | LXR agonist treatment caused a substantial increase in the expression levels of ABCG5 and ABCG8, but this expression remained confined to the villus enterocytes with a modest gradient suggesting slightly lower levels in the crypt epithelium. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2403 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2403 |
| Organ | liver |
| MedLine Reference | 12441342:1181 |
| Sentence | Likewise, LXR regulates the expression of ABCG5 and ABCG8 genes that promote secretion of sterols from the liver and decrease intestinal sterol retention, thereby facilitating coordinate regulation of sterol efflux and elimination. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2049 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2049 |
| Organ | gastric |
| MedLine Reference | 12897186:1193 |
| Sentence | Expression of ABCG5/G8 can also be regulated by LXRalpha. ( 50 ), although, because the exact specificity of this plant sterol transporter is not known, it is not possible to predict the contribution that it could make to the effects presented here. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i2 p301 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/2/301 |
| Organ | liver |
| MedLine Reference | 14657202:1112 |
| Sentence | LXR agonist increases the efficiency of biliary sterol secretion Treatment with the LXR agonist T0901317 increased the levels of ABCG5 and ABCG8 mRNA ( 21 ) and protein ( Fig. 4A ) in both liver and jejunum, resulting in decreased concentrations of the major neutral sterols (cholesterol, campesterol, and sitosterol) in the plasma and liver and increased bile-liver ratios of these sterols in wild-type mice ( Fig. 4B ). |
| Journal | Gastr. Liver Phys |
|---|---|
| Journal Reference | v284 i3 pG349 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G349 |
| Organ | gastric |
| MedLine Reference | 12576301:1158 |
| Sentence | In the intestine, LXRalpha induces ABCG5/G8 to efflux cholesterol and plant sterols (sitosterols) into the intestinal lumen. |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v144 i9 p3895 (2003) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/9/3895 |
| Organ | liver |
| MedLine Reference | 12933663:1044 |
| Sentence | Similarly, the ATP-binding cassette G5 (ABCG5) and ATP-binding cassette G8 (ABCG8) transporters, responsible for clearing cholesterol from the liver, are also regulated by LXRalpha ( 21 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | G8 |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i24 p21344 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/24/21344 |
| Organ | liver |
| MedLine Reference | 12672813:1240 |
| Sentence | Furthermore, LXR-mediated induction of ABCG5/G8 in liver and small intestine increases excretion of cholesterol into bile and feces, resulting in reduction in cholesterol absorption ( 32 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i9 p1728 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/9/1728 |
| Organ | liver |
| MedLine Reference | 12777468:1095 |
| Sentence | Because ABCG5 and ABCG8 are regulated by LXRalpha, we examined whether these two transporters were affected by endotoxin. |
| Organism | Mus musculus |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i3 pG630 (2003) |
| Tissue | epithelia |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/3/G630 |
| MedLine Reference | 12773300:1383 |
| Sentence | First, LXRalpha/RXR activates the half-transporters ABCG5/ABCG8 ( 47 ), which have been implicated in biliary cholesterol secretion and intestinal cholesterol absorption ( 56 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i38 p36091 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/38/36091 |
| Organ | gastric |
| MedLine Reference | 12847102:1011 |
| Sentence | LXR activation induces the expression of ATP-binding cassette (ABC) transporters, such as ABCG5 and ABCG8, which inhibit intestinal absorption of cholesterol and phytosterols. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i44 p45980 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/44/45980 |
| MedLine Reference | 15319426:1273 |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v45 i2 p253 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/2/253 |
| Organ | gastric |
| MedLine Reference | 14617739:1298 |