| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:5972::positive |
| Entities | REN <+-- NR1H3 |
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Circulation Res |
| Journal Reference | v92 i9 p1033 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/92/9/1033 |
| MedLine Reference | 12690040:1170 |
| Sentence | Transcription factor binding sites close to the promoter include CREB, Pit-1, 2,3 and an atypical binding site for the transcription factor LXRalpha. 5 Mutagenesis experiments suggest that all three of these sites are required for stimulation of renin expression by cAMP. |
| Organism | Mus musculus |
|---|---|
| CellLineName | JG |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i17 p15252 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/17/15252 |
| Organ | kidney |
| MedLine Reference | 12551904:1034 |
| Sentence | Furthermore, using a yeast one-hybrid screening approach, we demonstrated that LXRalpha bound to this sequence, whereas functional studies using promoter/reporter gene chimeric constructs revealed that LXRalpha increased basal levels of renin expression and mediated the cAMP-dependent induction of mouse and human renin gene expression ( 8 ). |
| Organ | kidney |
|---|---|
| MedLine Reference | 15353176:7 |
| Sentence | These results suggest that LXRalpha plays an important role in the cAMP-mediated regulation of human renin gene transcription by binding to CNRE. |
| Organism | Mus musculus |
|---|---|
| CellLineName | LA |
| Journal | PNAS |
| Journal Reference | v97 i15 p8513 (2000) |
| Journal Link | http://www.pnas.org/cgi/content/full/97/15/8513 |
| MedLine Reference | 10890879:1112 |
| Sentence | Next, we examined the possibility that LXRalpha is a cAMP-inducible transcription activator that interacts with CNRE to stimulate renin gene expression in response to cAMP. |