| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:10062::positive |
| Entities | PPARA --+> NR1H3 |
| References | 17 |
| Connectivity | 2 |
| Effect | positive |
| Journal | ATVB |
|---|---|
| Journal Reference | v22 i5 p717 (2002) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/22/5/717 |
| Organ | liver |
| MedLine Reference | 12006382:1102 |
| Sentence | Whereas PPAR has been shown to induce the hepatic expression of LXR , 68 which subsequently upregulates the expression of cholesterol 7 -hydroxylase (CYP7A1), 69 fibrates reduce the activity of this enzyme in rodents and humans. 70 A?A?A? 72 By contrast, PPAR has been reported as a positive regulator of murine and human CYP7A promoter activity. 73 Thus, the role of PPAR in CYP7A expression and activity is not completely understood. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1255 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1255 |
| MedLine Reference | 12730332:1132 |
| Sentence | Therefore, LXR could show inhibition of PPAR signaling by forming not only LXR /RXR , but also PPAR /LXR in a competition with functional PPAR /RXR formation. |
| Organism | Mus musculus |
|---|---|
| Journal | Eur. J. Biochem |
| CellType | macrophage |
| Journal Reference | v268 i12 p3490 (2001) |
| Journal Link | http://www.ejbiochem.org/cgi/content/full/268/12/3490 |
| MedLine Reference | 11422379:1274 |
| Sentence | Ligand activation of PPARalpha has been shown to lead to primary induction of the LXRalpha gene and to coupled induction of the ABC transporter ABCA1 in macrophages [ 53 ]. |
| Organism | Mus musculus |
|---|---|
| Journal | JPET |
| Journal Reference | v309 i3 p861 (2004) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/309/3/861 |
| Organ | liver |
| MedLine Reference | 14960661:1219 |
| Sentence | Previously, it was shown that in rats activation of PPARalpha led to increased LXRalpha expression in the liver (Tobin et al., 2000 ). |
| Journal | Lipid Res |
|---|---|
| CellType | macrophage |
| Journal Reference | v43 i1 p2 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| MedLine Reference | 11792716:1199 |
| Sentence | In addition, the LXR gene is induced by PPAR and PPAR ( 76 ) ( 77 ) ( 78 ) that may in turn be activated by the newly synthesized unsaturated fatty acids. |
| Journal | Lipid Res |
|---|---|
| CellType | macrophage |
| Journal Reference | v43 i2 p177 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/177 |
| MedLine Reference | 11861659:1220 |
| Sentence | Ligand activation of PPAR leads to primary induction of LXR expression and to coupled induction of the ABCA1 and apoE genes, which are both direct LXR targets ( 88 ) ( 89 ) ( 90 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v44 i5 p953 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/5/953 |
| MedLine Reference | 12588951:1331 |
| Sentence | Recently, a transcriptional cascade was described in macrophages whereby PPAR activation mediated Nr1h3 transcription that, in turn, increased Abca1 transcription ( 71 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Mol. Endocrin |
| CellType | adipocyte |
| Journal Reference | v17 i2 p172 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/2/172 |
| MedLine Reference | 12554745:1173 |
| Sentence | This regulation of LXR by PPAR activation was observed in a murine adipocyte cell line, in human primary adipocytes and obese Zucker rats. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i3 p1705 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/3/1705 |
| MedLine Reference | 11694526:1144 |
| Sentence | PPARalpha/RXR binding to PPRE was not affected by SA but was enhanced by OA , PUFA , and PPAR ligands, demonstrating that blocking the effects of PUFA on LXR/RXR-LXRE binding are not due to nonspecific inhibition of the assays by the fatty acid moiety. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1240 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1240 |
| Organ | liver |
| MedLine Reference | 12730331:1050 |
| Sentence | The results demonstrate that activation of PPAR represses LXR signaling through reduction of LXR/RXR heterodimerization in the liver. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | adipocyte |
| Journal Reference | v44 i8 p1441 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1441 |
| MedLine Reference | 12754280:1219 |
| Tissue | mesangia |
|---|---|
| MedLine Reference | 12595494:7 |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | McArdle RH7777 |
| MedLine Reference | 14960721:4 |
| Organism | Mus musculus |
|---|---|
| CellLineName | REF |
| Journal | Mol. Endocrin |
| CellType | macrophage |
| Journal Reference | v16 i3 p506 (2002) |
| Tissue | peritoneal |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/3/506 |
| MedLine Reference | 11875109:1043 |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| CellType | macrophage |
| Journal Reference | v22 i8 p2607 (2002) |
| Journal Link | http://mcb.asm.org/cgi/content/full/22/8/2607 |
| MedLine Reference | 11909955:1030 |
| Journal | Lipid Res |
|---|---|
| CellType | macrophage |
| Journal Reference | v42 i9 p1339 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/9/1339 |
| MedLine Reference | 11518753:1066 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i12 p10691 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/12/10691 |
| Organ | liver |
| MedLine Reference | 11781314:1206 |