| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:4023::positive |
| Entities | LPL <+-- NR1H3 |
| References | 12 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | ATVB |
| Journal Reference | v23 i7 p1169 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/7/1169 |
| Organ | liver |
| MedLine Reference | 12615685:1165 |
| Sentence | At present, the only bona fide gene selectivity of the LXR subtypes that has been described is that the LXR response element controlling the lipoprotein lipase gene responds only to LXR and not to LXRA?A?. 55 Regardless of the true mechanistic origins of the apparent gene selectivities, the observations and rationales described above suggest the tantalizing possibility that agonists selective for LXRA?A?, with a low expression in liver, may offer a solution to the triglyceride-raising problems of the LXR /A?A? dual agonists that have been disclosed to date. |
| Organism | Mus musculus |
|---|---|
| CellLineName | HEK 293 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i46 p43018 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/46/43018 |
| MedLine Reference | 11562371:1147 |
| Sentence | In addition, LXRalpha-mediated transcription was significantly higher than that of LXReta, further supporting the notion that the Lpl gene is more selectively activated by LXRalpha than LXReta. |
| Organism | Mus musculus |
|---|---|
| Journal | JPET |
| Journal Reference | v309 i3 p861 (2004) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/309/3/861 |
| Organ | liver |
| MedLine Reference | 14960661:1243 |
| Sentence | LXR agonist treatment of mice also led to significant increase in LPL mRNA in the liver, consistent with a previous report (Zhang et al., 2001 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| CellType | macrophage |
| Journal Reference | v17 i6 p985 (2003) |
| Tissue | fat |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| MedLine Reference | 12690094:1129 |
| Sentence | Similar to ApoE, the regulation of LPL gene expression by LXR is tissue specific. |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v23 i10 p3583 (2003) |
| Tissue | fecal |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/10/3583 |
| Organ | gastric |
| MedLine Reference | 12724417:1031 |
| Sentence | In addition, LXR is known to directly influence the transcription of genes encoding fatty acid synthase ( 17 ), lipoprotein lipase ( 57 ), cholesterol ester transfer protein ( 29 ), and stearoyl-CoA desaturase 1 ( 28 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2563 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2563 |
| Organ | liver |
| MedLine Reference | 12421815:1028 |
| Sentence | LXR positively regulates the expression of the genes encoding lipoprotein lipase (LPL ) ( 8 ), cholesterol ester transfer protein ( 9 ), and the ATP-binding cassette (ABC ) A1 transporter ( 10 , 11 ). |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i12 p1997 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/12/1997 |
| Organ | liver |
| MedLine Reference | 12454259:1163 |
| Sentence | The oxysterol-responsive transcription factor, LXR, also increased LPL expression in the liver ( 76 ) and caused fatty liver. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i1 p136 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/1/136 |
| MedLine Reference | 12518032:1189 |
| Sentence | In addition to ABCA1, activation of LXR may also increase the expression of a number of genes involved in fatty acid metabolism, including SREBP-1c, fatty acid synthase, and lipoprotein lipase ( 8 A?A?A? 10 ). |
| Journal | Gastr. Liver Phys |
|---|---|
| CellType | macrophage |
| Journal Reference | v284 i3 pG349 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G349 |
| MedLine Reference | 12576301:1161 |
| Sentence | LXRalpha also induces lipoprotein lipase and ApoE in macrophages. |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i6 p1019 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/1019 |
| MedLine Reference | 12663743:1034 |
| Sentence | Both LXR and LXRA?A? have been shown to regulate several important genes in reverse cholesterol transport, including the ATP-dependent cholesterol transporter (ABCA1), cholesteryl ester transfer protein, apolipoprotein E, and lipoprotein lipase in vitro and in vivo ( 20 , 21 , 22 , 23 , 24 ). |
| Journal | Lipid Res |
|---|---|
| CellType | macrophage |
| Journal Reference | v43 i1 p2 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| Organ | liver |
| MedLine Reference | 11792716:1215 |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2039 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2039 |
| Organ | liver |
| MedLine Reference | 12923232:1150 |