| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-llid:1071::positive |
| Entities | CETP <+-- NR1H3 |
| References | 16 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i6 p985 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/985 |
| MedLine Reference | 12690094:1138 |
| Sentence | The LXR target genes CETP and PLTP and are both remodeling enzymes that transfer lipids between lipoproteins. |
| Journal | ATVB |
|---|---|
| Journal Reference | v22 i10 p1535 (2002) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/22/10/1535 |
| MedLine Reference | 12377728:1134 |
| Sentence | Regulation of CETP transcription is by the same LXR/RXR nuclear receptor heterodimer that activates transcription of ABCA1. 99 Similarly, ARP-1 has been shown to upregulate CETP gene transcription. 74 Thus, a plausible candidate mechanism for the antioxidant vitaminA?A?A?associated blunting of the favorable effects of lipid therapy on HDL2-C 27 and coronary disease 28 would be an antioxidant-mediated induction of CETP activity, as has been shown for probucol 94 , 95 and vitamin E. 100 PL Transfer Protein |
| Organism | Mus musculus |
|---|---|
| Journal | ATVB |
| CellType | hepatocyte |
| Journal Reference | v23 i7 p1169 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/7/1169 |
| MedLine Reference | 12615685:1198 |
| Sentence | Luo and Tall 59 have shown that the human CETP gene contains a functional LXR response element; we have extended these results by demonstrating that synthetic LXR agonists increase CETP expression in primary human hepatocytes (unpublished data, 2001). |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v143 i7 p2548 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/7/2548 |
| Organ | liver |
| MedLine Reference | 12072387:1334 |
| Sentence | In other mammals, such as hamsters, rabbits, and humans, LXR action induces expression of CETP, which enhances the transfer of cholesteryl ester from HDL to LDL. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i27 p24767 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/27/24767 |
| Organ | liver |
| MedLine Reference | 11331284:1011 |
| Sentence | Hepatic CETP gene expression is increased in response to dietary hypercholesterolemia, an effect that is mediated by the activity of liver X receptor/retinoid X receptor (LXR/RXR) on a direct repeat 4 element in the CETP promoter. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i5 p902 (2003) |
| Tissue | thromb |
| Journal Link | http://www.jlr.org/cgi/content/full/44/5/902 |
| MedLine Reference | 12588948:1392 |
| Sentence | The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by LXR. |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v44 i7 p1322 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/7/1322 |
| MedLine Reference | 12730302:1438 |
| Sentence | The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by LXR. |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v45 i7 p1169 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/7/1169 |
| Organ | liver |
| MedLine Reference | 15102878:1415 |
| Sentence | CETP expression is regulated by LXR activity ( 211 ); decreased RXR/LXR activity in the liver likely contributes to the reduced CETP expression seen during the APR. |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v16 i9 p2065 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/9/2065 |
| Organ | liver |
| MedLine Reference | 12198243:1351 |
| Sentence | Mol Cell 6:507A?A?A?515 [Medline] Luo Y, Liang CP, Tall AR 2001 The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by LXR. |
| Organ | liver |
|---|---|
| MedLine Reference | 11182136:1 |
| Sentence | Expression of cholesterol 7alpha-hydroxylase, cholesteryl ester transfer protein and certain ATP-binding cassette transporters that are responsible for cholesterol efflux from cells is regulated by LXR and its ligands. |
| Journal | Gastr. Liver Phys |
|---|---|
| CellType | hepatocyte |
| Journal Reference | v284 i3 pG349 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/3/G349 |
| MedLine Reference | 12576301:1157 |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i6 p1019 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/1019 |
| MedLine Reference | 12663743:1034 |
| Organism | Mus musculus |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v14 i22 p2831 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/22/2831 |
| Organ | liver |
| MedLine Reference | 11090131:1125 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i36 p28240 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/36/28240 |
| MedLine Reference | 10858438:1231 |
| Journal | Lipid Res |
|---|---|
| CellType | macrophage |
| Journal Reference | v43 i1 p2 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |
| Organ | liver |
| MedLine Reference | 11792716:1215 |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v44 i10 p1956 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/10/1956 |
| MedLine Reference | 12897188:1036 |