| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-go:0005321::unknown |
| Entities | HDL <--- NR1H3 |
| References | 5 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i49 p49072 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/49/49072 |
| Organ | liver |
| MedLine Reference | 12947111:1036 |
| Sentence | Since then, multiple LXR target genes, including ABCA1 ( 10 ), apoE ( 11 ), CETP ( 12 ), and PLTP ( 13 , 14 ), have been identified, indicating the critical role of LXR in regulating HDL metabolism. |
| Organism | Mus musculus |
|---|---|
| Journal | ATVB |
| Journal Reference | v23 i7 p1169 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/7/1169 |
| Organ | artery |
| MedLine Reference | 12615685:1052 |
| Sentence | Genes Regulated by LXR in Mice and Humans From a drug development point of view, perhaps the most interesting gene induced by LXR is ABCA1, which is a lipid pump that functions to remove excess cholesterol from cells. 14 The critical role of ABCA1 in cellular cholesterol homeostasis and HDL metabolism is supported by the fact that genetic deficiency of ABCA1, which results in Tangier disease, leads to cholesterol accumulation in several tissues and vanishingly low HDL levels. 14 The importance of ABCA1 in atherosclerosis was supported by the observation that patients heterozygous for ABCA1 deficiency have ~3-fold increased risk for coronary artery disease. 15 Therefore, induction of the ABCA1 gene by LXR agonists might lead to a decreased cholesterol burden in the artery wall as well as increased HDL levels. |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12923232:1 |
| Sentence | The LXR ligand T0901317 elevates ATP binding cassette transporter A1 (ABCA1) and HDL levels in animal models and induces moderate lipogenesis through upregulation of sterol regulatory element binding protein 1c (SREBP1c). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| CellType | macrophage |
| Journal Reference | v23 i16 p5780 (2003) |
| Journal Link | http://mcb.asm.org/cgi/content/full/23/16/5780 |
| MedLine Reference | 12897148:1032 |
| Sentence | Thus, the ability of LXR agonists to increase serum HDL levels may result, at least in part, from increased reverse cholesterol transport. |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i6 p1019 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/6/1019 |
| MedLine Reference | 12663743:1035 |
| Sentence | Consistent with their ability to activate reverse cholesterol transport, full agonists of LXR have also been reported to increase HDL in mice. |