| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5468:out-urn:agi-llid:10062::positive |
| Entities | PPARG --+> NR1H3 |
| References | 12 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | ATVB |
| CellType | macrophage |
| Journal Reference | v24 i1 p147 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/1/147 |
| MedLine Reference | 14615393:1204 |
| Sentence | Alternatively, ligand activated PPARgamma could stimulate the gene expression of LXRalpha, with downstream stimulation of ABCA1 expression. 55,56 The outcome of this cascade of gene regulation is to promote cholesterol efflux from macrophages in the lesion. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v276 i47 p43509 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43509 |
| MedLine Reference | 11546778:1205 |
| Sentence | The LXRalpha gene was also recently shown to be directly regulated by peroxisome proliferator-activated receptor gamma, which is activated by fatty acids and their metabolites ( 38 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | ec |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i28 p25448 (2003) |
| Tissue | endothelial |
| Journal Link | http://www.jbc.org/cgi/content/full/278/28/25448 |
| Organ | liver |
| MedLine Reference | 12704191:1105 |
| Sentence | It has been shown that PPARgamma activators are able to regulate LXR expression, and thereby indirectly influence ABCA1 mRNA levels ( 13 ), and that ligands for PPARdelta directly regulate the expression of ABCA1 via an unknown mechanism ( 14 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v278 i48 p48283 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/48/48283 |
| MedLine Reference | 12970362:1208 |
| Sentence | However, since PPARgamma also regulates the expression of LXRalpha ( 18 , 42 ), it could be that this in vitro effect is secondarily mediated through increased LXRalpha expression and thus increased potential for activation through LXRalpha. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v279 i46 p47626 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/46/47626 |
| MedLine Reference | 15339912:1195 |
| Sentence | Because the expression of LXRalpha is positively regulated by PPARgamma agonists in adipocytes ( 42 A? 45 ), this LXR element, in the presence of an endogenously generated ligand, could account for increased apoE gene expression in response to ciglitazone. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Tissue | fat |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| MedLine Reference | 14703507:1014 |
| Sentence | Furthermore, LXRalpha expression is induced by peroxisome proliferator-activated receptor gamma (PPARgamma), the master regulator of fat cell differentiation. |
| Organism | Mus musculus |
|---|---|
| CellType | macrophage |
| MedLine Reference | 11604492:5 |
| Sentence | We further demonstrate that LXR and PPAR gamma ligands cooperate to induce LXR alpha expression in human but not murine macrophages. |
| Organism | Mus musculus |
|---|---|
| Journal | PNAS |
| CellType | macrophage |
| Journal Reference | v99 i18 p11896 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/18/11896 |
| MedLine Reference | 12193651:1154 |
| Sentence | Similarly, activation of PPARgamma leads to a direct increase in the expression of LXRalpha via a PPARgamma binding site in the LXRalpha promoter ( 25 , 26 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Cell. Biol |
| CellType | adipocyte |
| Journal Reference | v24 i8 p3430 (2004) |
| Tissue | fat |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/8/3430 |
| Organ | liver |
| MedLine Reference | 15060163:1294 |
| Sentence | Previously, it has been demonstrated that LXRalpha expression is regulated by the potent adipogenic transcription factor PPARgamma ( 1 , 5 ). |
| Journal | Gastr. Liver Phys |
|---|---|
| CellType | macrophage |
| Journal Reference | v284 i4 pG551 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/4/G551 |
| MedLine Reference | 12631556:1140 |
| Sentence | Predominantly expressed in macrophages, PPARgamma induces LXR, which, in turn, promotes cellular efflux of phospholipids and cholesterol into high-density lipoproteins with subsequent cholesterol delivery to hepatocytes. |
| Organism | Mus musculus |
|---|---|
| CellType | macrophage |
| MedLine Reference | 11172721:3 |
| Journal | Cell |
|---|---|
| CellType | macrophage |
| Journal Reference | v104 i4 p503 (2001) |
| Journal Link | http://www.cell.com/cgi/content/full/104/4/503 |
| MedLine Reference | 2892195115 |