| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:10062:out-urn:agi-go:0004886::negative |
| Entities | retinoid-X receptor |--- NR1H3 |
| References | 5 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v14 i22 p2819 (2000) |
| Journal Link | http://www.genesdev.org/cgi/content/full/14/22/2819 |
| MedLine Reference | 11090130:1194 |
| Sentence | Cholesterol-derived oxysterols function as LXR ligands to regulate the expression of RXR/LXR target genes (shown in black boxes), which, in turn, modulate intracellular free cholesterol levels through increased elimination, efflux, and storage. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i33 p29561 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/33/29561 |
| MedLine Reference | 12045201:1125 |
| Sentence | Constant LXR concentrations were titrated against increasing concentrations of HA-CXR with chicken RXR and anti-HA antibody included in all reactions (Fig. 2 c , lanes 3-12 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | Neuro 2A |
| Journal | J. Biol. Chem |
| CellType | neural |
| Journal Reference | v278 i30 p27688 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/30/27688 |
| MedLine Reference | 12754201:1065 |
| Sentence | LXR acts in a heterodimeric complex with retinoid X receptor (RXR), and the response of genes to LXR activators is increased in the presence of RXR activators, such as 9- cis -retinoic acid ( 15 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v279 i11 p9905 (2004) |
| Tissue | peritoneal |
| Journal Link | http://www.jbc.org/cgi/content/full/279/11/9905 |
| MedLine Reference | 14699103:1107 |
| Sentence | Induction of VEGF by LXR was particularly dependent on the combined presence of RXR agonist ( Fig. 1 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1255 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1255 |
| MedLine Reference | 12730332:1116 |
| Sentence | The inhibitory effect of LXR activation was abolished with increasing concentrations of RXR . |