| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:7157:out-urn:agi-llid:7376::positive |
| Entities | NR1H2 <+-- TP53 |
| References | 20 |
| Effect | positive |
| Connectivity | 2 |
| MedLine Reference | 12771027:1223 |
|---|---|
| Sentence | Another interesting question is how p53 regulated transcription of NER genes is important to the cells response to damage. p53 appears to regulate basal levels of p48 and XPC independent of UV-inducible responses, maintaining higher levels of these gene products in wt cells for immediate use in the early steps of NER ( 12 , 19 , 20 ). p53's induction of p48 and XPC following DNA damage is somewhat late in the UV response, typically reaching maximal levels for both after 24 h. |
| Journal | Carcinogenesis |
| Journal Reference | v24 i5 p843 (2003) |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/24/5/843 |
| MedLine Reference | 12173040:0 |
|---|---|
| Sentence | A mutation in codon 122 of the mouse p53 gene resulting in a T to L amino acid substitution (T122-->L) is frequently associated with skin cancer in UV-irradiated mice that are both homozygous mutant for the nucleotide excision repair (NER) gene Xpc (Xpc(-/-)) and hemizygous mutant for the p53 gene. |
| CellLineName | UV |
| Organ | skin |
| Organism | Mus musculus |
| MedLine Reference | 10676627:1023 |
|---|---|
| Sentence | However, it remains to be established whether the role of p53 to promote efficient global NER is a general phenomenon, applicable to a variety of classes of DNA damage including PAH-DNA adducts, or whether it is largely restricted to a particular type of UV-induced DNA lesion. |
| Journal | Cancer Res |
| Journal Reference | v60 i3 p517 (2000) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/60/3/517 |
| MedLine Reference | 10426782:1172 |
|---|---|
| Sentence | We suggest that p53 stimulates NER and the recovery of mRNA synthesis by regulating the steady-state levels of one or more proteins (such as p21 waf1 and/or p48) that are limiting for these recovery processes. |
| CellType | fibroblast |
| CellLineName | XP-E |
| Journal | Carcinogenesis |
| Journal Reference | v20 i8 p1389 (1999) |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/20/8/1389 |
| MedLine Reference | 11895854:1179 |
|---|---|
| Sentence | Ever since the reports that p21 interacts physically with PCNA ( 27 ), and that p53 stimulates NER, there has been a high degree of interest in exploring the possibility whether downstream effectors of p53 are in some fashion involved in NER. |
| Journal | Carcinogenesis |
| Journal Reference | v23 i3 p403 (2002) |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/23/3/403 |
| MedLine Reference | 12574133:1040 |
|---|---|
| Sentence | However, the mechanism by which p53 enhances NER is not understood. |
| Journal | EMBO |
| Journal Reference | v22 i4 p975 (2003) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/22/4/975 |
| MedLine Reference | 12208738:1109 |
|---|---|
| Sentence | In the case of UV, p53 enhances GG-NER without affecting TC-NER (19) . |
| CellType | fibroblast |
| CellLineName | XP-C |
| Journal | Cancer Res |
| Journal Reference | v62 i17 p4899 (2002) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/62/17/4899 |
| MedLine Reference | 12234998:1038 |
|---|---|
| Sentence | Using this approach, we demonstrated that the efficient global NER of the major N 2-guanine adduct formed by BPDE is p53-dependent (24) . |
| Journal | Cancer Res |
| Journal Reference | v62 i18 p5288 (2002) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/62/18/5288 |
| MedLine Reference | 12499281:1244 |
|---|---|
| Sentence | However, this result does not exclude the possibility that p53 would alter the NER activity. |
| CellLineName | HeLa |
| Journal | Cancer Res |
| Journal Reference | v62 i24 p7364 (2002) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/62/24/7364 |
| MedLine Reference | 15289314:1038 |
|---|---|
| Sentence | However, it has been suggested that p53 regulates NER through transcriptional activation of genes involved in DNA damage recognition (12 , 13 , 14) . |
| Journal | Cancer Res |
| Journal Reference | v64 i15 p5118 (2004) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/64/15/5118 |
| Organism | Mus musculus |
| MedLine Reference | 12376471:1023 |
|---|---|
| Journal | Carcinogenesis |
| Journal Reference | v23 i10 p1631 (2002) |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/23/10/1631 |
| MedLine Reference | 11331289:1206 |
|---|---|
| CellType | fibroblast |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i28 p25813 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/28/25813 |
| MedLine Reference | 9095000:6 |
|---|---|
| CellType | keratinocyte |
| Organism | Mus musculus |
| MedLine Reference | 12195423:2 |
|---|
| MedLine Reference | 12242345:7 |
|---|---|
| CellType | fibroblast |
| MedLine Reference | 13679996:2 |
|---|
| MedLine Reference | 15665582:5 |
|---|
| MedLine Reference | 9764141:2 |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 15539943:2 |
|---|
| MedLine Reference | 10753968:1146 |
|---|---|
| CellType | fibroblast |
| CellLineName | HPV+ |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i15 p11492 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/15/11492 |