| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-go:0004886:out-urn:agi-llid:10062::unknown |
| Entities | retinoid-X receptor ---> NR1H3 |
| References | 27 |
| Effect | unknown |
| Connectivity | 2 |
| MedLine Reference | 10747970:7 |
|---|---|
| Sentence | RXR repression was associated with decreased LXRalpha and PPARalpha mRNA levels and reduced RXR x RXR, RXR x PPAR and RXR x LXR binding activities in nuclear extracts. |
| Organ | liver |
| MedLine Reference | 11604492:1218 |
|---|---|
| Sentence | LXRalpha, LXReta, and PPARgamma activate the hLXRalpha promoter. (A) LXRalpha/RXRalpha and LXReta/RXR heterodimers activate the -2625-bp LXRalpha proximal promoter. |
| CellLineName | HepG 2 |
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i22 p7558 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/22/7558 |
| Organism | Mus musculus |
| MedLine Reference | 12773300:1285 |
|---|---|
| Sentence | The immunofluorescence data corroborated the results from the immunoblots, showing increased expression of ABCA1 following LXRalpha/RXR ligand treatment compared with no treatment ( Fig. 8 B ). |
| Tissue | epithelia |
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i3 pG630 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/3/G630 |
| Organism | Mus musculus |
| MedLine Reference | 9973192:1120 |
|---|---|
| Sentence | As part of a heterodimer, RXRs activate the transcription of several permissive partners, including peroxisome proliferator activated receptors (27) , LXR (29) , and OR1 (30) . |
| Tissue | thyroid |
| Journal | Cancer Res |
| Journal Reference | v59 i3 p521 (1999) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/59/3/521 |
| Organism | Rattus norvegicus |
| MedLine Reference | 14534304:1031 |
|---|---|
| Sentence | RXR is also able to form homodimers, and heterodimers with other nuclear receptors such as the retinoic acid receptor (RAR) and liver X receptor (LXR). |
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i51 p51340 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/51/51340 |
| MedLine Reference | 11741944:1034 |
|---|---|
| Sentence | Consistent with this, recent studies have shown that selective agonists of RXR , which activate LXR/RXR heterodimers, significantly reduce lesion size and the progression of atherosclerosis in apoE-/- animals ( 18 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i7 p4713 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/7/4713 |
| MedLine Reference | 12970175:1 |
|---|---|
| Sentence | We report the crystal structure of the ligand-binding domains (LBDs) of LXRalpha and RXRbeta complexed to the synthetic LXR agonist T-0901317 and the RXR agonist methoprene acid (Protein Data Base entry 1UHL). |
| Organ | liver |
| MedLine Reference | 11562371:1032 |
|---|---|
| Sentence | LXRalpha and LXReta are members of the nuclear hormone receptor superfamily that form heterodimers with RXRs and can be activated by both RXR and LXR ligands ( 21 ). |
| Organ | liver |
| Tissue | fat |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i46 p43018 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/46/43018 |
| Organism | Mus musculus |
| MedLine Reference | 12091489:1028 |
|---|---|
| Sentence | This LXR/RXR dimer can be activated by oxysterols (ligands for LXR) or by retinoids (ligands for RXR) ( 1 , 2 , 11 , 12 ). |
| Organ | liver |
| Journal | Lipid Res |
| Journal Reference | v43 i7 p1054 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/7/1054 |
| MedLine Reference | 12730332:1090 |
|---|---|
| Sentence | The inhibitory efficiency of LXR activation was attenuated by coexpressed RXR in a dose-dependent manner (Fig. 5B ). |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1255 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1255 |
| Organism | Rattus norvegicus |
| MedLine Reference | 10479651:1137 |
|---|---|
| CellLineName | THP I |
| Journal | ATVB |
| Journal Reference | v19 i9 p2105 (1999) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/19/9/2105 |
| MedLine Reference | 2363497073 |
|---|---|
| CellLineName | HepG 2 |
| Journal | ATVB |
| Journal Reference | v23 i8 p1479 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/8/1479 |
| MedLine Reference | 9030682:1 |
|---|
| MedLine Reference | 12615696:1036 |
|---|---|
| CellType | macrophage |
| Organ | liver |
| Journal | ATVB |
| Journal Reference | v23 i3 p475 (2003) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/23/3/475 |
| Organism | Mus musculus |
| MedLine Reference | 10187832:1208 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i15 p10421 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/15/10421 |
| Organism | Rattus norvegicus |
| MedLine Reference | 12045201:1122 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i33 p29561 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/33/29561 |
| MedLine Reference | 12869545:1299 |
|---|---|
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i40 p38913 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/40/38913 |
| Organism | Mus musculus |
| MedLine Reference | 9121558:2 |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 11027684:5 |
|---|---|
| CellType | hepatocyte |
| MedLine Reference | 11149950:4 |
|---|---|
| CellType | macrophage |
| Tissue | fat |
| Organism | Mus musculus |
| MedLine Reference | 11967256:4 |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 12470667:6 |
|---|---|
| CellLineName | 3T3 L1 |
| Organism | Mus musculus |
| MedLine Reference | 12612088:7 |
|---|---|
| CellType | macrophage |
| Organ | liver |
| Organism | Mus musculus |
| MedLine Reference | 12697904:7 |
|---|---|
| Tissue | fat |
| Organism | Mus musculus |
| MedLine Reference | 12882648:6 |
|---|---|
| Organ | liver |
| Organism | Mus musculus |
| MedLine Reference | 14764426:2 |
|---|---|
| Organ | liver |
| MedLine Reference | 10406462:1193 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v13 i7 p1105 (1999) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/13/7/1105 |
| Organism | Rattus norvegicus |