| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:7507:out-urn:agi-llid:7376::positive |
| Entities | NR1H2 <+-- XPA |
| References | 6 |
| Effect | positive |
| Connectivity | 2 |
| MedLine Reference | 15256455:1117 |
|---|---|
| Sentence | In mammalian cells, NER is initiated by six core factors, XPA, RPA, XPC-HR23B, XPG, ERCC1-XPF, and the TFIIH complex, which are essential for damage recognition and dual incision (26) . |
| CellLineName | NIH 3T3 |
| Journal | Cancer Res |
| Journal Reference | v64 i14 p4849 (2004) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/64/14/4849 |
| Organism | Mus musculus |
| MedLine Reference | 10339546:1121 |
|---|---|
| Sentence | XPA protein forms a tight stoichiometric complex with RPA, a heterotrimeric single-stranded DNA binding factor with a total molecular mass of 116 kDa that is critically involved in the human NER reaction ( 24 , 25 , 27 ). |
| Journal | PNAS |
| Journal Reference | v96 i11 p6090 (1999) |
| Journal Link | http://www.pnas.org/cgi/content/full/96/11/6090 |
| MedLine Reference | 11687625:1163 |
|---|---|
| Sentence | Both XPA and CSB proteins form a NER complex with TFIIH ( 2 , 26 , 27 ). |
| CellType | neural |
| Journal | PNAS |
| Journal Reference | v98 i23 p13379 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/23/13379 |
| Organism | Mus musculus |
| MedLine Reference | 11285198:1037 |
|---|---|
| Sentence | The XPA protein is involved in both the TCR and GGR pathway, and mutations in the XPA gene, therefore, affect both forms of NER ( 24 , 25 ). |
| CellLineName | XP |
| Organ | skin |
| Journal | Carcinogenesis |
| Journal Reference | v22 i4 p619 (2001) |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/22/4/619 |
| Organism | Mus musculus |
| MedLine Reference | 12082027:1040 |
|---|---|
| Sentence | These reports could lead to the simple conclusion that intracellular concentration of XPA is responsible for NER modulation in mammalian cells. |
| Tissue | testis |
| Journal | Carcinogenesis |
| Journal Reference | v23 i6 p1039 (2002) |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/23/6/1039 |
| MedLine Reference | 14517266:1071 |
|---|---|
| Sentence | Secondly, the removal of XPA from the pre-incubation completely abolished the binding of any additional factor to NER-C2 (Figure? 2 B, panel II), suggesting that association of XPA with NER-C2 results in the subsequent NER-C3 complex. |
| Journal | EMBO |
| Journal Reference | v22 i19 p5293 (2003) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/22/19/5293 |