| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:6256:out-urn:agi-llid:10062::positive |
| Entities | NR1H3 <+-- RXRA |
| References | 3 |
| Effect | positive |
| Connectivity | 2 |
| MedLine Reference | 10890879:1196 |
|---|---|
| Sentence | Willy et al. ( 1 , 2 ) reported that LXRalpha heterodimerized with RXRalpha and is involved in the transcriptional regulation of cholesterol 7alpha-hydroxylase by binding to the DR4/LXRE. |
| Journal | PNAS |
| Journal Reference | v97 i15 p8513 (2000) |
| Journal Link | http://www.pnas.org/cgi/content/full/97/15/8513 |
| Organism | Mus musculus |
| MedLine Reference | 8621574:1125 |
|---|---|
| Sentence | Willy and co-workers ( 20 ) have also demonstrated that LXRalpha interacts with endogenous RXRalpha to mediate transcriptional activation through DR4 elements; however, under these conditions, activation was observed only in the presence of RXR-specific ligands. |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i16 p9189 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/16/9189 |
| Organism | Mus musculus |
| MedLine Reference | 11027684:1219 |
|---|---|
| Sentence | Inclusion of RXRalpha in the binding reactions with LXRalpha, LXReta, and TRalpha stimulated the formation of high affinity protein-DNA complexes containing LXRalpha/RXRalpha, LXReta/RXRalpha, and TRalpha/RXRalpha, respectively. |
| CellType | hepatocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i2 p974 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/2/974 |