| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:10062:out-urn:agi-llid:5465::negative |
| Entities | PPARA |--- NR1H3 |
| References | 6 |
| Effect | negative |
| Connectivity | 2 |
| MedLine Reference | 12730332:7 |
|---|---|
| Sentence | Supportively, in vivo administration of the LXR ligand to mice and rat primary hepatocytes substantially decreased hepatic mRNA levels of PPARalpha-targeted genes in both basal and PPARalpha agonist-induced conditions. |
| CellType | hepatocyte |
| Organ | liver |
| Organism | Mus musculus |
| MedLine Reference | 14960721:4 |
|---|---|
| Sentence | The binding of LXRalpha:PPARalpha to human CYP7A1 Site I was increased in the presence of either LXRalpha or PPARalpha ligands. |
| CellLineName | McArdle RH7777 |
| Organism | Rattus norvegicus |
| MedLine Reference | 10022764:4 |
|---|---|
| Sentence | In contrast, a strong interaction of RIP140 with the PPARalpha and LXRalpha heterodimerization partner retinoid-X-receptor alpha (RXRalpha) required the presence of its cognate ligand, 9-cis retinoic acid. |
| Organ | liver |
| MedLine Reference | 12730331:1232 |
|---|---|
| Sentence | As described in the accompanying paper ( 49 ), PPAR heterodimerizes with both LXR and ???? as efficiently as with RXR. |
| Organ | liver |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1240 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1240 |
| Organism | Mus musculus |
| MedLine Reference | 8621574:1015 |
|---|---|
| Sentence | LXRalpha bound directly to PPARalpha, as well as to the common heterodimerization partner 9- cis -retinoic acid receptor (RXRalpha). |
| Journal | J. Biol. Chem |
| Journal Reference | v271 i16 p9189 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/16/9189 |
| Organism | Mus musculus |
| MedLine Reference | 12435796:1151 |
|---|---|
| Sentence | Because LXRalpha is a direct target gene of PPARalpha and PPARgamma (Tobin et al., 2000 ; Chawla et al., 2001 ; Chinetti et al., 2001 ), the known increased expression of CYP4A10 and CYP4A14 after peroxisome proliferator treatment (Heng et al., 1997 ) could involve induction of LXRalpha. |
| Organ | brain |
| Journal | Mol. Pharm |
| Journal Reference | v62 i6 p1299 (2002) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/62/6/1299 |
| Organism | Mus musculus |